HOME >> BIOLOGY >> NEWS
Baltimore chemist wins national award for insights into body's carbohydrates

Chemist Yuan Chuan Lee of Timonium, Md., will be honored April 3 by the world's largest scientific society for his achievements in revealing how carbohydrates function as biological signals in the body. He will receive the 2001 Claude S. Hudson Award in Carbohydrate Chemistry from the American Chemical Society at its national meeting in San Diego.

Human genes and the proteins they code for are prominent news these days, "but it's not going to be a complete story without carbohydrates," said Lee, a biochemist at Johns Hopkins University, Baltimore. "Without proteins' final adornment with carbohydrates, most of them don't function properly."

Lee's own research focuses on the role of carbohydrates in signaling, the communication within the body between molecules and between cells.

"In the late 1970s we started to examine liver cells, which have very powerful carbohydrate receptors (for signaling)," he said. "We realized that if we could design a small molecule with a high binding affinity (for the receptors), it could become a targeting device in drug delivery."

By being able to target a drug to a specific tissue, both dosage and side effects can decrease, Lee explained.

While working on the project, Lee's team discovered what became known as the cluster effect: that the right number of carbohydrates - three properly spaced galactoses, in the case of human liver cells - will find a receptor and latch on with dramatically more efficiency than two, for example.

The biochemist said several pharmaceutical companies are exploring the approach, which can potentially cut drug doses not by half but by the hundreds - or even thousands - fold.

A native of Taiwan, Lee said his father is an artist - "but he could have been a good scientist," he added. "Of eight brothers and sisters, six of us work in some field of science and technology. So it must run in the family."

Lee received his undergraduate degree from the National Unive
'"/>

Contact: Rodney Pearson
r_pearson@acs.org
202-872-4400
American Chemical Society
28-Mar-2001


Page: 1 2

Related biology news :

1. Drug tested for HIV prevention in Baltimore
2. Nobel Laureate David Baltimore To Speak To NYU Undergrads
3. NASA Exhibit, Experts To Be In Baltimore Focusing On Space Research Improving Earth-Based Health Care
4. UT Southwestern biochemist honored with NIH Directors Pioneer Award
5. NJIT chemist speaks Aug. 25 about compound derived from pine tree
6. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
7. U of T research answers key question in biochemistry
8. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry
9. Rutgers chemist uses NMR to elucidate protein-DNA interaction
10. New multidisciplinary research tops chemists meeting Aug. 22-26
11. Wisconsin chemists find a new chink in TBs armor

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ComplianceOnline’s Medical Device ... on 7th and 8th June 2018 in San Francisco, CA. The Summit brings together ... as several distinguished CEOs, board directors and government officials from around the world to ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: