HOME >> BIOLOGY >> NEWS
Baltimore chemist wins national award for insights into body's carbohydrates

Chemist Yuan Chuan Lee of Timonium, Md., will be honored April 3 by the world's largest scientific society for his achievements in revealing how carbohydrates function as biological signals in the body. He will receive the 2001 Claude S. Hudson Award in Carbohydrate Chemistry from the American Chemical Society at its national meeting in San Diego.

Human genes and the proteins they code for are prominent news these days, "but it's not going to be a complete story without carbohydrates," said Lee, a biochemist at Johns Hopkins University, Baltimore. "Without proteins' final adornment with carbohydrates, most of them don't function properly."

Lee's own research focuses on the role of carbohydrates in signaling, the communication within the body between molecules and between cells.

"In the late 1970s we started to examine liver cells, which have very powerful carbohydrate receptors (for signaling)," he said. "We realized that if we could design a small molecule with a high binding affinity (for the receptors), it could become a targeting device in drug delivery."

By being able to target a drug to a specific tissue, both dosage and side effects can decrease, Lee explained.

While working on the project, Lee's team discovered what became known as the cluster effect: that the right number of carbohydrates - three properly spaced galactoses, in the case of human liver cells - will find a receptor and latch on with dramatically more efficiency than two, for example.

The biochemist said several pharmaceutical companies are exploring the approach, which can potentially cut drug doses not by half but by the hundreds - or even thousands - fold.

A native of Taiwan, Lee said his father is an artist - "but he could have been a good scientist," he added. "Of eight brothers and sisters, six of us work in some field of science and technology. So it must run in the family."

Lee received his undergraduate degree from the National Unive
'"/>

Contact: Rodney Pearson
r_pearson@acs.org
202-872-4400
American Chemical Society
28-Mar-2001


Page: 1 2

Related biology news :

1. Drug tested for HIV prevention in Baltimore
2. Nobel Laureate David Baltimore To Speak To NYU Undergrads
3. NASA Exhibit, Experts To Be In Baltimore Focusing On Space Research Improving Earth-Based Health Care
4. UT Southwestern biochemist honored with NIH Directors Pioneer Award
5. NJIT chemist speaks Aug. 25 about compound derived from pine tree
6. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
7. U of T research answers key question in biochemistry
8. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry
9. Rutgers chemist uses NMR to elucidate protein-DNA interaction
10. New multidisciplinary research tops chemists meeting Aug. 22-26
11. Wisconsin chemists find a new chink in TBs armor

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health ... and Management Systems Society (HIMSS) Analytics for achieving ... Adoption Model sm . In addition, CHS previously ... U.S. hospitals using an electronic medical record (EMR). ... its high level of EMR usage in an ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition and ... Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market ... CAGR of 29.63% between 2017 and 2022. Continue ... ... ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board ... Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has been selected ... member of the winning team for the 2015 Breakthrough Prize in Fundamental physics for ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System ... standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography ...
(Date:10/7/2017)... WA (PRWEB) , ... October ... ... industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution ... ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C metagenome ...
Breaking Biology Technology:
Cached News: