HOME >> BIOLOGY >> NEWS
Belgian researchers explore revolutionary approach to angiogenesis

Geneva, Switzerland: A revolutionary approach to angiogenesis[1] by a team of Belgian researchers could make cancer treatment more effective at killing tumours.

Dr. Olivier Feron and his team from the University of Louvain Medical School in Brussels have turned the whole concept of targeting tumour blood vessels on its head. Instead of the conventional approach of trying to starve tumour cells of the blood supply they need to grow, they are doing the opposite opening up the tumour blood supply to allow better access for cancer drugs and more effective radiotherapy.

The potential for exploiting tumour blood vessels has been made possible by their discovery in a study in mice that the arterioles (blood vessels less than 0.5mm in diameter) that feed tumours have the ability to contract in response to increases in pressure within their lumen (the space within the blood vessels). Equivalent sized blood vessels in healthy tissue can't do this.

"What this means is that we may have the potential to use drugs to selectively exploit these blood vessels against the tumour instead of, or before, killing them. Exploiting tumour blood vessels instead of destroying them by anti-angiogenic drugs constitutes a paradigm shift in approach to angiogenesis," Dr. Feron told a news briefing today (Thursday 30 September) at the EORTC-NCI-AACR[2] Symposium on Molecular Targets and Cancer Therapeutics.

The key to the ability of tumour arterioles to contract lies with endothelin-1 (ET-1) a peptide released in large amounts by many tumour cells, which stimulates their proliferation.

"The effect of ET-1 in tumours has been underestimated up to now," Dr. Feron said. "ET-1 has been known for years in cardiology as a very potent blood vessel constrictor. Here, we found that the myogenic tone (mechanical force) with which the tumour blood vessels contract and expand is exquisitely dependent on the endothelin pathway.

"What we did was to us
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
41-227-612-211
European Organisation for Research and Treatment of Cancer
30-Sep-2004


Page: 1 2

Related biology news :

1. Award winning researchers reveal potential new role for Glivec
2. $7.5 Million grant to Yale researchers for role of viruses in cancer
3. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
4. Joslin researchers clarify mechanisms for beta-cell formation
5. Virginia Tech researchers to release findings on Smith River Project
6. Molecular motor myosin VI moves hand over hand, researchers say
7. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
8. Emory researchers map structure of anti-cancer molecule
9. Leukemia stem cells identified by Stanford researchers
10. EURYI Award given for the first time to 25 young European researchers
11. Carnegie Mellon researchers to demonstrate autonomous robotthat will seek life in Atacama Desert

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... 19, 2017 , ... The new and improved Oakton® pocket testers, from Cole-Parmer, ... upright with a new cap design that is versatile, functional and leakproof. They are ... to test water quality. , The Oakton pocket testers have many user-friendly and functional ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... a partnership with Cytena GmbH to launch the CloneSelect™ Single-Cell Printer™ in North ... to isolate single cells and provide visual documentation of monoclonality for use in ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... move of the SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August to ... an improved user experience and incorporate a number of enhancements and new features, ...
(Date:9/15/2017)... ... September 15, 2017 , ... ... it calls an ‘Internal Seed B’ round of financing, totaling $600,000. The ... completed using a ‘SAFE’ documentation structure at a company valuation of $10M. ...
Breaking Biology Technology:
Cached News: