The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Belgian researchers explore revolutionary approach to angiogenesis

e a an endolthelin antagonist in this case a cyclic peptide called BQ123 to target selectively one of the ET receptors, ET-A, that we found was particularly dense in the tumour arterioles. This peptide completely wiped out the ability of the arterioles to contract and kept them wide open. We were able to demonstrate, using laser doppler probes and imaging that this increased blood flow to the tumour but that healthy tissue was not affected. We were then also able demonstrate that administering BQ123 could significantly increase the delivery of the anti-cancer drug cyclophosphamide to the tumour. Furthermore, tumour response to fractionated radiotherapy was also improved significantly because the increased blood flow carried more oxygen to the tumour."

Dr. Feron, who is an assistant professor and research associate in the Department of Internal Medicine at the University of Louvain, said that the team was now planning to start Phase I clinical trials in patients. "The chances for this anti-tumour adjuvant therapy to be well tolerated are high as ET-1 antagonists would be used acutely to produce an immediate effect on the tumour blood vessels i.e. given at the same time that the chemotherapy or radiotherapy is administered."

He said that although the research was in mice and that it was early days as the concept still had to be proved in patients, the principle of keeping tumour arterioles open to boost responses to treatment should work in the many tumour types where ET-1 was expressed.


'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
41-227-612-211
European Organisation for Research and Treatment of Cancer
30-Sep-2004


Page: 1 2

Related biology news :

1. Award winning researchers reveal potential new role for Glivec
2. $7.5 Million grant to Yale researchers for role of viruses in cancer
3. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
4. Joslin researchers clarify mechanisms for beta-cell formation
5. Virginia Tech researchers to release findings on Smith River Project
6. Molecular motor myosin VI moves hand over hand, researchers say
7. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
8. Emory researchers map structure of anti-cancer molecule
9. Leukemia stem cells identified by Stanford researchers
10. EURYI Award given for the first time to 25 young European researchers
11. Carnegie Mellon researchers to demonstrate autonomous robotthat will seek life in Atacama Desert

Post Your Comments:
(Date:11/25/2009)...tate University assistant professors recently rece...(NSF) to continue research beneficial to understan...000. , Christopher Blackwood, assistant professo...arded grants to support two separate research proj...tter Decomposer Communities and Functions from the...
(Date:11/24/2009)...nds of years it has been prescribed by traditional...om headaches and stomach pain to fever and flu. ,...University have been able to scientifically prove ... otherwise known as Brazilian mint. , Testing thi...d by researcher Graciela Rocha was able to show th...
(Date:11/24/2009)...ence is opening new doors to understanding how sou...aring of a marine mammal or if they hear it at al...ay scanners that NASA uses to detect flaws in the ... allowing scientists to peek inside the giant head...e-dimensional replicas of a whale,s hearing anatom...
Breaking Biology News(10 mins):Kent State University professors focus research on the environment with grants totaling $890,000 2Got a pain? -- Have a cup of Brazilian mint 2Rocket science leads to new whale discovery 2Drake Center is Site for 243 6 Million NIH Grant to Study Mental Rehearsal that Improves Motor Skills in Stroke Patients 60443 1Drake Center is Site for 243 6 Million NIH Grant to Study Mental Rehearsal that Improves Motor Skills in Stroke Patients 60443 2Drake Center is Site for 243 6 Million NIH Grant to Study Mental Rehearsal that Improves Motor Skills in Stroke Patients 60443 3AARP Commends Legislature For Saving Critical Health Care Program 60438 1Health of Subzero 1992 Winner of Melbourne Cup Threatened After Customs Mix Up 60433 1Health of Subzero 1992 Winner of Melbourne Cup Threatened After Customs Mix Up 60433 2Health of Subzero 1992 Winner of Melbourne Cup Threatened After Customs Mix Up 60433 3
(Date:11/25/2009)...Newswire/--Reportlinker.comannouncesthatanewmarket...azilBioethanolMarketAnalysisandForecaststo2013 ,...ioethanol-Market-Analysis-and-Forecasts-to-2013.ht...tsto2013 ,, Summary ,, Thereportprovidesde...ketandtheBrazilbioethanolmarketinparticular.Italso...
(Date:11/24/2009)... The New York investment bank KTA Capital,s client...n AU$6.7 mil convertible note private placement wi...ement was arranged by KTA Capital as Neuren,s excl... New York (PRWEB) November 23, 2009 -- ...al, LLC ("KTA Capital") has announced th...
(Date:11/24/2009)... Health care employment grew by 29,000 jobs in O... consistent growth during the U.S. recession. Howe...uble, and health systems are coming closer to havi...ust administrators. , (Vo...ontinued growing in October despite the shedding o...
(Date:11/24/2009)...Newswire/--BlueMarbleEnergyCorp.announcedtodaythat...PDA)wererecentlyawarded$2millionbyWashingtonState,...ate/publicpartnershiptoconstructthestate,sfirstspe..., "Thisinvestmentwillsignificantlyspeedthedevelo...olnCounty,"saidBlueMarbleEnergyCEOKellyOgilvie."We...
Breaking Biology Technology:Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 3Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 5Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 6Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 7Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 8Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 9KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2
Other News:
...Images of Sound Waves, and.Shakespearean Acoustics... 10, 1999---What talent might insect-eating bats p...he sounds of a person's voice reveal warning signs...ckground noise in the Arctic Ocean provide indicat...
...chigan Technological University and Arizona State....rkshop on pollution prevention.research and teachi...gators for the project are Dr. David Shonnard of t...Tech and Dr. Stephen Beaudoin of.the Chemical, Bio...
. Imagine a lion, poised to bring down its prey, drawing and holding a.breath, then giving chase for 20 minutes. Few, if any, large land-based.predators could do such a thing. But seals and o
...t and detergent found in many shampoos and.toothpa... to kill animal and.human papillomavirus, accordin...te (SDS) was found in cell culture and animal test...luding human immunodeficiency virus (HIV),.herpes ...
Largest Acoustics Meeting In History Expected 2Largest Acoustics Meeting In History Expected 3Largest Acoustics Meeting In History Expected 4Largest Acoustics Meeting In History Expected 5Largest Acoustics Meeting In History Expected 6Largest Acoustics Meeting In History Expected 7Largest Acoustics Meeting In History Expected 8Largest Acoustics Meeting In History Expected 9Largest Acoustics Meeting In History Expected 10Largest Acoustics Meeting In History Expected 11Largest Acoustics Meeting In History Expected 12Largest Acoustics Meeting In History Expected 13Largest Acoustics Meeting In History Expected 14Educators Launch Internet Based Workshop On Pollution Prevention 2Video And Data Link Provide Unique "Seal's Eye View" Of The World 2Topical Agent Found To Kill Papillomavirus 2Topical Agent Found To Kill Papillomavirus 3
SAN FRANCISCO, CA -March 29, 2007 -- Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) announced they have identified a critical genetic factor in the control of many aspects of
La Jolla, CA - Scientists have identified three different signals that indicate damage to chloroplasts the photosynthetic factories of plant cells that give plants their green color but little is know
... N.Y. -- Cockroaches, leeches, and snails are ordi...dinner. But to biologists who are interested in b... phenomena, these organisms provide valuable infor... systems.... A new book, An Introduction to Nervou...
...g prospect of being eaten, one might imagine that ...h escape at once in the desperate hurry to escape ...icates that this is not the case, and in fact fish...logical order. This research was carried out at th...
Gladstone scientists identify critical gene factor in heart development 2All roads lead to GUN1 2All roads lead to GUN1 3New book presents neurobiology from an evolutionary perspective 2