Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression

This news release is also available in French and Japanese. (To view the PDF in Japanese, please download Acrobat 5.0. with Asian font-pack).

The molecule that spawns "plaque" buildup in the brains of Alzheimer's patients may also play a role in normal gene expression, suggests a study using cultured cells. The study will be published in the 6 July issue of the international journal, Science.

If these findings prove true in humans, they may help scientists understand why the plaques form and perhaps even the basic mechanisms that lead to the disease.

The study also raises the possibility of unwanted side effects from drugs intended to prevent plaque formation, by revealing a biological use for the reaction that produces the plaque molecules. Such drugs are currently under investigation as possible Alzheimer's therapies.

Researchers have long wondered about the normal function of the parent protein to the plaque molecules--the "amyloid precursor protein," or "APP," which is embedded in the cell membranes of neurons in the brain.

The protein is split into pieces by a series of enzymes. The last of these reactions, called "gamma cleavage," cuts the remaining molecule into two smaller pieces.

The infamous Alzheimer's plaques form from one of these pieces, the "beta-amyloid" peptide, which is secreted from the cell. The other piece is the APP "tail," which dangles from the membrane into the cell. Its function has thus far been a mystery.

In their Science study, authors Xinwei Cao and Thomas C. Sdhof of the University of Texas Southwestern Medical Center and Howard Hughes Medical Institute propo

Contact: Ginger Pinholster
American Association for the Advancement of Science

Page: 1 2 3

Related biology news :

1. Benefits of lung surgery reported for emphysema patients
2. Benefits Are Likely From Vitamin B-6 In Premenstrual Syndrome
3. Tip Sheet: Health Benefits Of Caffeinated Beverages
4. Chocolate: Potential Health Benefits
5. Controlling Problem Snakes: Saipan Benefits From USGS Research
6. Test For Genetic Trait May Indicate Heart Benefits Of Hormone Replacement Therapy
7. High-pressure Oxygen Therapy Could Offer Widespread Benefits
8. Composting Livestock Waste Provides Benefits
9. New "Wonder Peanut" Beats Olive Oil In Healthful Benefits
10. Purdue-Made Soil Benefits The Environment
11. Pets Provide Physiological Benefits For Women Living Alone

Post Your Comments:

(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded ... of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for ... fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates ...
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply ... a time. So which eye do you rinse first if a dangerous substance enters both ... Duo Eye Wash with its unique dual eye piece. , “Whether its dirt and ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
Breaking Biology Technology:
Cached News: