HOME >> BIOLOGY >> NEWS
Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression

This news release is also available in French and Japanese. (To view the PDF in Japanese, please download Acrobat 5.0. with Asian font-pack).

The molecule that spawns "plaque" buildup in the brains of Alzheimer's patients may also play a role in normal gene expression, suggests a study using cultured cells. The study will be published in the 6 July issue of the international journal, Science.

If these findings prove true in humans, they may help scientists understand why the plaques form and perhaps even the basic mechanisms that lead to the disease.

The study also raises the possibility of unwanted side effects from drugs intended to prevent plaque formation, by revealing a biological use for the reaction that produces the plaque molecules. Such drugs are currently under investigation as possible Alzheimer's therapies.

Researchers have long wondered about the normal function of the parent protein to the plaque molecules--the "amyloid precursor protein," or "APP," which is embedded in the cell membranes of neurons in the brain.

The protein is split into pieces by a series of enzymes. The last of these reactions, called "gamma cleavage," cuts the remaining molecule into two smaller pieces.

The infamous Alzheimer's plaques form from one of these pieces, the "beta-amyloid" peptide, which is secreted from the cell. The other piece is the APP "tail," which dangles from the membrane into the cell. Its function has thus far been a mystery.

In their Science study, authors Xinwei Cao and Thomas C. Sdhof of the University of Texas Southwestern Medical Center and Howard Hughes Medical Institute propo
'"/>

Contact: Ginger Pinholster
gpinhols@aaas.org
202-326-6421
American Association for the Advancement of Science
5-Jul-2001


Page: 1 2 3

Related biology news :

1. Benefits of lung surgery reported for emphysema patients
2. Benefits Are Likely From Vitamin B-6 In Premenstrual Syndrome
3. Tip Sheet: Health Benefits Of Caffeinated Beverages
4. Chocolate: Potential Health Benefits
5. Controlling Problem Snakes: Saipan Benefits From USGS Research
6. Test For Genetic Trait May Indicate Heart Benefits Of Hormone Replacement Therapy
7. High-pressure Oxygen Therapy Could Offer Widespread Benefits
8. Composting Livestock Waste Provides Benefits
9. New "Wonder Peanut" Beats Olive Oil In Healthful Benefits
10. Purdue-Made Soil Benefits The Environment
11. Pets Provide Physiological Benefits For Women Living Alone

Post Your Comments:
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
(Date:4/27/2015)... y HEIDELBERG , Alemania, April ... obtiene la patente para un nuevo receptor utilizando tecnología ... una necesidad no cubierta en el tratamiento de millones ... Molecular Health ha anunciado hoy que ha recibido una patente ... patente apoya el descubrimiento de Molecular Health de que ...
(Date:4/27/2015)... , April 27, 2015 ... this release, please scroll to bottom . ... equities: Lexicon Pharmaceuticals Inc. (NASDAQ: LXRX ), ... Pharmaceuticals Corporation (NASDAQ: SNTA ), Spectrum Pharmaceuticals ... (NASDAQ: MDVN ). Free research report on ...
(Date:4/27/2015)... 2015 DryLet, LLC a biotechnology ... such as animal waste reduction, bioremediation, wastewater treatment, ... wastewater treatment plants and restaurant kitchen settings, announced ... Texas Commission on Environmental Quality (TCEQ) Environmental Trade ... , The company will highlight three of its ...
(Date:4/27/2015)... Elsevier , a world-leading provider of scientific, technical ... Office   have announced the winners of the Qatar University ... last week at Qatar University, ... guests representing Qatar,s top scientific community. ... Al-Misnad , President of Qatar University. ...
Breaking Biology Technology:Molecular Health obtiene la patente para un nuevo receptor 2Molecular Health obtiene la patente para un nuevo receptor 3Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 2Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 3Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 4Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 5DryLet to Showcase Multiple Products at Texas Commission on Environmental Quality Trade Fair and Conference May 5-6 in Austin, Texas 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 5
Cached News: