HOME >> BIOLOGY >> NEWS
Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression

This news release is also available in French and Japanese. (To view the PDF in Japanese, please download Acrobat 5.0. with Asian font-pack).

The molecule that spawns "plaque" buildup in the brains of Alzheimer's patients may also play a role in normal gene expression, suggests a study using cultured cells. The study will be published in the 6 July issue of the international journal, Science.

If these findings prove true in humans, they may help scientists understand why the plaques form and perhaps even the basic mechanisms that lead to the disease.

The study also raises the possibility of unwanted side effects from drugs intended to prevent plaque formation, by revealing a biological use for the reaction that produces the plaque molecules. Such drugs are currently under investigation as possible Alzheimer's therapies.

Researchers have long wondered about the normal function of the parent protein to the plaque molecules--the "amyloid precursor protein," or "APP," which is embedded in the cell membranes of neurons in the brain.

The protein is split into pieces by a series of enzymes. The last of these reactions, called "gamma cleavage," cuts the remaining molecule into two smaller pieces.

The infamous Alzheimer's plaques form from one of these pieces, the "beta-amyloid" peptide, which is secreted from the cell. The other piece is the APP "tail," which dangles from the membrane into the cell. Its function has thus far been a mystery.

In their Science study, authors Xinwei Cao and Thomas C. Sdhof of the University of Texas Southwestern Medical Center and Howard Hughes Medical Institute propo
'"/>

Contact: Ginger Pinholster
gpinhols@aaas.org
202-326-6421
American Association for the Advancement of Science
5-Jul-2001


Page: 1 2 3

Related biology news :

1. Benefits of lung surgery reported for emphysema patients
2. Benefits Are Likely From Vitamin B-6 In Premenstrual Syndrome
3. Tip Sheet: Health Benefits Of Caffeinated Beverages
4. Chocolate: Potential Health Benefits
5. Controlling Problem Snakes: Saipan Benefits From USGS Research
6. Test For Genetic Trait May Indicate Heart Benefits Of Hormone Replacement Therapy
7. High-pressure Oxygen Therapy Could Offer Widespread Benefits
8. Composting Livestock Waste Provides Benefits
9. New "Wonder Peanut" Beats Olive Oil In Healthful Benefits
10. Purdue-Made Soil Benefits The Environment
11. Pets Provide Physiological Benefits For Women Living Alone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ... board any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to ... Delta,s biometric ... Sky Club is now integrated into the boarding process to allow ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert ... a media edge server, the M820, which features the company,s hybrid ... software provided by Tera Probe, Inc., will be showcased during the ... the NAB show at the Las Vegas ... ...
Breaking Biology News(10 mins):
(Date:8/18/2017)... ... August 18, 2017 , ... OAI, a leading Silicon ... Microfluidics Industries, announces the new Model 800E front and backside, semi-automatic mask aligner ... mask aligners. OAI has already received and installed several orders for the ...
(Date:8/17/2017)... , ... August 17, 2017 , ... ... research and personalized medicine, today announced the launch of a new breast cancer ... The study’s goal is to evaluate the potential for early detection of recurrent ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... Electrospinning and Electrospraying line of nanofiber and nanoparticle ... equipment for the lab to fully automated pilot plants and equipment for ...
(Date:8/16/2017)... ... August 16, 2017 , ... While art and science are ... closely connected than one might think. A Mesh Is Also a Snare, a ... University City Science Center’s Esther Klein Gallery (EKG) on August 17 and run through ...
Breaking Biology Technology:
Cached News: