HOME >> BIOLOGY >> NEWS
Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression

This news release is also available in French and Japanese. (To view the PDF in Japanese, please download Acrobat 5.0. with Asian font-pack).

The molecule that spawns "plaque" buildup in the brains of Alzheimer's patients may also play a role in normal gene expression, suggests a study using cultured cells. The study will be published in the 6 July issue of the international journal, Science.

If these findings prove true in humans, they may help scientists understand why the plaques form and perhaps even the basic mechanisms that lead to the disease.

The study also raises the possibility of unwanted side effects from drugs intended to prevent plaque formation, by revealing a biological use for the reaction that produces the plaque molecules. Such drugs are currently under investigation as possible Alzheimer's therapies.

Researchers have long wondered about the normal function of the parent protein to the plaque molecules--the "amyloid precursor protein," or "APP," which is embedded in the cell membranes of neurons in the brain.

The protein is split into pieces by a series of enzymes. The last of these reactions, called "gamma cleavage," cuts the remaining molecule into two smaller pieces.

The infamous Alzheimer's plaques form from one of these pieces, the "beta-amyloid" peptide, which is secreted from the cell. The other piece is the APP "tail," which dangles from the membrane into the cell. Its function has thus far been a mystery.

In their Science study, authors Xinwei Cao and Thomas C. Sdhof of the University of Texas Southwestern Medical Center and Howard Hughes Medical Institute propo
'"/>

Contact: Ginger Pinholster
gpinhols@aaas.org
202-326-6421
American Association for the Advancement of Science
5-Jul-2001


Page: 1 2 3

Related biology news :

1. Benefits of lung surgery reported for emphysema patients
2. Benefits Are Likely From Vitamin B-6 In Premenstrual Syndrome
3. Tip Sheet: Health Benefits Of Caffeinated Beverages
4. Chocolate: Potential Health Benefits
5. Controlling Problem Snakes: Saipan Benefits From USGS Research
6. Test For Genetic Trait May Indicate Heart Benefits Of Hormone Replacement Therapy
7. High-pressure Oxygen Therapy Could Offer Widespread Benefits
8. Composting Livestock Waste Provides Benefits
9. New "Wonder Peanut" Beats Olive Oil In Healthful Benefits
10. Purdue-Made Soil Benefits The Environment
11. Pets Provide Physiological Benefits For Women Living Alone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:6/14/2017)...  IBM (NYSE: IBM ) is introducing several innovative ... to developing collaboration between startups and global businesses, taking place ... the event, nine startups will showcase the solutions they have ... France is one ... a 30 percent increase in the number of startups created ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
(Date:10/9/2017)... Arizona (PRWEB) , ... October 09, 2017 , ... ... Kindred, a four-tiered line of medical marijuana products targeting the needs of consumers ... and packaging of Kindred takes place in Phoenix, Arizona. , As operators of ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... for microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical ... broad range of contract analysis services for advanced applications. Services will leverage ...
(Date:10/7/2017)... Mass. , Oct. 6, 2017  The ... work of three scientists, Jacques Dubochet, Joachim ... breakthrough developments in cryo-electron microscopy (cryo-EM) ... technology within the structural biology community. The winners ... Scientists can now routinely produce highly resolved, three-dimensional ...
Breaking Biology Technology:
Cached News: