HOME >> BIOLOGY >> NEWS
Benzene responsible for high percentage of leukemia deaths induced by smoking

Benzene, a potent chemical found in cigarette smoke and automobile emissions, appears responsible for between 8 percent and 48 percent of all smoking-induced leukemia deaths, a new University of North Carolina at Chapel Hill study indicates. The chemical also causes between 12 percent and 58 percent of smoking-related deaths from acute myeloid leukemia.

How likely smokers are to develop the life-threatening illness depends largely on how much they smoke, scientists say.

Dr. Irva Hertz-Picciotto, professor of epidemiology at the UNC-CH School of Public Health, conducted the study with Dr. Jeffrey E. Korte of the International Agency for Research on Cancer in Lyon, France; graduate student Mark R. Schultz and Dr. Louise M. Ball, professor of environmental sciences and engineering, both at UNC-CH; and Dr. Eric J. Duell of Harvard University.

A report on their findings appears in the current (April) issue of the journal Environmental Health Perspectives. They originally intended to help explain why smokers were one-and-a-half to two times more likely to develop the blood-borne cancer than non-smokers and the possible influence of benzene.

"We extrapolated down from different studies that have been done on leukemia and people exposed to benzene in the workplace and established what's called a dose-response curve," Hertz-Picciotto said. "We found that linear mathematical models provided more plausible estimates of benzene's influence than a quadratric model."

Some scientists and industry officials argue that linear models over-estimate the risks at low doses. They say that only at high doses when it overwhelms the body's ability to detoxify the chemical can it cause cancer.

The shape of the dose-response curve is important for the Occupational Safety and Health Administration and Environmental Protection Agency when they attempt to set standards to protect workers and the public. If cancer increases linearly with increases in benzene levels,
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
3-May-2000


Page: 1 2 3

Related biology news :

1. Scientists discover genetic marker responsible for two-fold increase in risk of rheumatoid arthritis
2. Possible link discovered between gene responsible for blood vessel development and ACD in newborns
3. Study of dyslexic brain finds three word forms responsible for reading success
4. Gene mutation responsible for Chrohns disease inflammation identified in Temple study
5. Researchers identify second gene responsible for rare syndrome associated with skeletal defects
6. Specific gene mutations responsible for congenital heart defects
7. Gene responsible for developmental disorder identified
8. Researchers develop guidelines to establish identity of genes responsible for complex diseases
9. Gene responsible for anemia (type CDA-1) discovered
10. Gene responsible for rewinding bodys clock described by scientists at TSRI
11. Researchers find mechanism responsible for neuronal death in prion diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: