Big-bottomed sheep have a rare genetic mutation that builds muscl...( nce to the assumption that callipyge is...)

Big-bottomed sheep have a rare genetic mutation that builds muscle, not fat

nce to the assumption that callipyge is also imprinted.

"Imprinted genes are like mushrooms, because they are present in groups," said Jirtle. "Moreover, they display a domino effect, in that one mutation of an imprinted gene could knock out five or 10 genes in one hit, especially when they are all regulated as a group."

"These are incredibly powerful and subtle genes that bring you into a whole different realm of thinking about gene regulation," said Jirtle. "In a way, we are at the end of the beginning. We know the specific gene mutation that leads to large bottoms in sheep, but now we have to find how it operates."

'"/>

Contact: Rebecca Levine
levin005@mc.duke.edu
919-684-4148
Duke University Medical Center
16-Sep-2002

Page: 1 2 3 4
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