HOME >> BIOLOGY >> NEWS
Bigger betas are better Protein found to provide pancreatic cells with protection against diabetes

(Philadelphia, PA) While studying the proteins in pancreatic beta (β) cells the cells that produce insulin researchers at the University of Pennsylvania Medical Center discovered how the protein enzyme Akt1 can cause mice β cells to grow larger and produce more insulin. Their findings, published in this months Nature Medicine, have direct implications for the current need to increase the number of human pancreatic cells available for transplant to diabetic patients.

"The mice bred to produce excess Akt1 protein were more tolerant of glucose and more resistant to diabetes in fact, we simply could not give them diabetes when we tried," said Morris J. Birnbaum, MD, PhD, associate director of the Penn Diabetes Center in the Penn Departments of Medicine & Cell and Molecular Biology and an investigator in the Howard Hughes Medical Institute. "The increase in Akt1 directly leads to an increase in the size, amount, and total production of insulin by β cells."

In the United States, diabetes is the seventh leading cause of death and currently effects over 15 million people. Medical science recognizes two forms of diabetes. Type 1 diabetes results from the immune systems destruction of pancreatic β cells. Type 2 diabetes results when the body cannot either produce enough insulin or properly use the insulin it does produce. Without insulin, the body cannot utilize glucose blood sugar which can lead to a variety of debilitating illnesses, including heart disease, blindness, and kidney failure.

Recently, surgeons have met with success in treating the disorder by transplanting clusters of pancreatic cells, called islets, into diabetic patients. Transplanted islets, which include β cells, have been shown to reestablish the production of insulin in the pancreas. Unfortunately, the demand for islets far outweighs the supply.

"What makes our findings so interesting, clinically, is the potential to enlarge our pool of β cells f
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
18-Oct-2001


Page: 1 2

Related biology news :

1. Bigger isnt always better--especially if youre a rodent
2. Spray Forming Aerospace Alloys For Bigger Aircraft
3. New Sunspot Cycle To Be Bigger Than Average
4. Mapping The Way To A Bigger Prawn
5. Bigger Biology Tackled Through Keyboards
6. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
7. Microbes eat their way to better concrete
8. Computer database being developed at Temple will allow for better inventory of chemicals
9. New and better drugs for tuberculosis goal of UH professor
10. Ants protect plants better when jacked up on nectar
11. The blind really do hear better

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), ... published by MarketsandMarkets, the market is expected to be worth USD 18.98 billion ... Continue Reading ... ...      (Logo: ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... Ca (PRWEB) , ... May 25, 2017 , ... ... of Terumo BCT case studies, describing how process development and economic ... new results of T-cell expansion using a hollow-fiber bioreactor system, along with techniques ...
(Date:5/24/2017)... ... May 23, 2017 , ... Triumph ... modular buildings, announced the launch of the Mobile Big Room. This state-of-the-art ... help support on-site teamwork and collaboration. , The Mobile Big Room enables ...
(Date:5/23/2017)... Westminster, Colorado (PRWEB) , ... May 23, 2017 , ... ... amaranth as the most troublesome and difficult to control weed in 12 categories of ... found. , Almost 200 weed scientists across the U.S. and Canada participated in the ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Vortex ... of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology ” ... result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig at ...
Breaking Biology Technology:
Cached News: