HOME >> BIOLOGY >> NEWS
Bigger betas are better Protein found to provide pancreatic cells with protection against diabetes

(Philadelphia, PA) While studying the proteins in pancreatic beta (β) cells the cells that produce insulin researchers at the University of Pennsylvania Medical Center discovered how the protein enzyme Akt1 can cause mice β cells to grow larger and produce more insulin. Their findings, published in this months Nature Medicine, have direct implications for the current need to increase the number of human pancreatic cells available for transplant to diabetic patients.

"The mice bred to produce excess Akt1 protein were more tolerant of glucose and more resistant to diabetes in fact, we simply could not give them diabetes when we tried," said Morris J. Birnbaum, MD, PhD, associate director of the Penn Diabetes Center in the Penn Departments of Medicine & Cell and Molecular Biology and an investigator in the Howard Hughes Medical Institute. "The increase in Akt1 directly leads to an increase in the size, amount, and total production of insulin by β cells."

In the United States, diabetes is the seventh leading cause of death and currently effects over 15 million people. Medical science recognizes two forms of diabetes. Type 1 diabetes results from the immune systems destruction of pancreatic β cells. Type 2 diabetes results when the body cannot either produce enough insulin or properly use the insulin it does produce. Without insulin, the body cannot utilize glucose blood sugar which can lead to a variety of debilitating illnesses, including heart disease, blindness, and kidney failure.

Recently, surgeons have met with success in treating the disorder by transplanting clusters of pancreatic cells, called islets, into diabetic patients. Transplanted islets, which include β cells, have been shown to reestablish the production of insulin in the pancreas. Unfortunately, the demand for islets far outweighs the supply.

"What makes our findings so interesting, clinically, is the potential to enlarge our pool of β cells f
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
18-Oct-2001


Page: 1 2

Related biology news :

1. Bigger isnt always better--especially if youre a rodent
2. Spray Forming Aerospace Alloys For Bigger Aircraft
3. New Sunspot Cycle To Be Bigger Than Average
4. Mapping The Way To A Bigger Prawn
5. Bigger Biology Tackled Through Keyboards
6. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
7. Microbes eat their way to better concrete
8. Computer database being developed at Temple will allow for better inventory of chemicals
9. New and better drugs for tuberculosis goal of UH professor
10. Ants protect plants better when jacked up on nectar
11. The blind really do hear better

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
(Date:3/29/2016)... RATON, Florida , March 29, 2016 ... or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are ... DNA in ink used in a variety of writing ... theft. Buyers of originally created collectibles from athletes on ... through forensic analysis of the DNA. ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... ... 26, 2016 , ... FireflySci has been manufacturing quartz and ... over the globe. Their cute firefly logo has been spreading to more and ... spectrophotometer calibration standards that never require recalibration. These revolutionary standards have changed ...
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical Informatics ... of the National Coordinator for Health IT (ONC) outlining a measurement approach to ... were available when and where it was needed. The organization of health informatics ...
(Date:5/24/2016)... ... May 24, 2016 , ... Cell ... injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded ... healing and tissue regeneration. , The novel method, developed by WPI faculty members ...
(Date:5/23/2016)... Ohio (PRWEB) , ... May 23, 2016 , ... ... Trends That Will Drive Precision Farming in 2017 and Beyond. The paper outlines ... practitioners in the precision ag industry. , “We’ve witnessed a lot of highs ...
Breaking Biology Technology:
Cached News: