Bile acid inhibits cell death in Huntington's disease

MINNEAPOLIS / ST. PAUL (July 24, 2002)--University of Minnesota researchers have found that a nontoxic bile acid produced in the body prevents apoptosis, or programmed cell death, in mice with Huntington's disease. This finding, to be published July 29 in the Proceedings of the National Academy of Sciences USA (PNAS), may eventually lead to a treatment for Huntington's disease (HD) in humans. HD is an untreatable neurological disorder caused by selective and progressive degeneration of neural cells.

In the study, led by Walter Low, Ph.D., professor of neurosurgery in the university's Medical School, a dose of tauroursodeoxycholic acid (TUDCA) was administered subcutaneously once every third day for six weeks in mice with the HD gene. Researchers found TUDCA was able to cross the blood / brain barrier, something many molecules are unable to do, resulting in decreased apoptosis in the section of the brain affected by HD and improving the neurological cell function in the mice.

"We're extremely encouraged by the neuroprotective function of TUDCA in Huntington's disease and will be examining its potential in future studies," said Low.

The bile acid's anti-apoptotic qualities were originally discovered in the laboratory of Clifford Steer, M.D., co-author of the article and director of the university's molecular gastroenterology program.

"We determined that this bile acid was unique in its ability to maintain the integrity of mitochondria, which is so important for normal cell function," said Steer. "By so doing, the TUDCA was able to significantly reduce brain cell death in a variety of conditions, including acute stroke, in rats. We were interested to see if this would be the case in Huntington's disease as well. What's exciting about TUDCA, in addition to its remarkable anti-apoptotic quality, is that it's made in our own bodies and causes virtually no side effects when given as a drug. TUDCA may even have potential for treating other

Contact: Deane Morrison
University of Minnesota

Page: 1 2

Related biology news :

1. Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
2. The amendment to the law on green Genetic Engineering inhibits innovation and research in Germany
3. Inhibition of cathepsin proteases inhibits tumor formation in transgenic mice
4. Obesity drug inhibits prostate tumor growth
5. Protein inhibits cell growth, may contribute to breast cancer
6. ENBREL combo therapy inhibits joint damage progression, offers significant RA symptom relief
7. Aspirin inhibits ovarian cancer growth, lab study finds
8. UIC chemists identify compound that inhibits cell migration
9. UT Southwestern researchers find protein that both instigates, inhibits heart growth in mice
10. Researchers explain how protein inhibits angiogenesis
11. Novel compound inhibits HIV replication in cell cultures, suggesting possible new type of AIDS drug

Post Your Comments:

(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/4/2020)... ... , ... Aesthetics Biomedical (ABM), a leading aesthetics product development ... the products and treatments developed, but also the dedicated team behind the brands ... built by ABM have received several honors already for 2020, each of which ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, ... President and CEO has been named one of the 100 most inspiring individuals ... PharmaVoice 100 honorees are selected based on how they have inspired their colleagues ...
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
Breaking Biology Technology:
Cached News: