Bim notes in the neuronal executioner's song

Brain damage often results after prolonged seizures as well as after brief or repetitive epileptic seizures. Previous work has indicated that loss of neurons in the hippocampus after seizures may be due to onset of programmed cell death. Members of the Bcl-2 family are known to activate a pathway ending in the release of several caspases, including the 'executioner,' caspase-3. David Henshall and colleagues, of Robert S. Dow Neurobiology Laboratories, investigate molecular members of the programmed cell death pathway and show that reduction of Bim (Bcl-2-interacting mediator of cell death) may provide protection from neuronal loss. The researchers examined Bim expression in both experimentally induced seizures in rats and in patients with temporal lobe epilepsy. In instances of experimentally-produced prolonged seizures that damaged the hippocampus in rats, Bim expression increased. Blocking upstream activators of Bim or using Bim antisense to block Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself from additional neural damage following epileptic seizures. Targeting this molecular pathway may be worthwhile for ameliorating seizure-induced brain injuries.

An accompanying commentary by Jerome Niquet and Claude Wasterlain, of Epilepsy Research Laboratory, place this work in context with the complexity of cell-death pathways and highlight specific areas of future analysis that are still required to understand the molecular mechanisms at play in neuronal damage.


Contact: Laurie Goodman
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Spiders make best ever Post-it notes
2. Lewis and Clark notes reveal history of human impacts
3. 2,000+ brown recluse spiders in a Kansas home inflict no bites in the occupants, UCR study notes
4. Up to one-third of all cancer cases may be prevented by healthy diets and exercise, notes FANSA
5. Technotes -- Pacific Northwest National Laboratorys summer news tipsheet
6. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
7. Link between neuronal calcium channel, mutated gene that causes Huntingtons disease identified
8. Researchers find mechanism responsible for neuronal death in prion diseases
9. Lithographic technique creates neuronal networks in a dish
10. Pay attention to potassium channels! First steps in the molecular identification of SK channels and their role in neuronal signal encoding.
11. Improvement in some patients who underwent neuronal transplantation following stroke, according to study by University of Pittsburgh researchers

Post Your Comments:

(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues in Regenerative ... Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy ... effective way to complete one? Will the study comply with all FDA requirements? ...
(Date:7/2/2020)... ... July 01, 2020 , ... ... phase 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute ... Led by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered 501(c)(3) ... and aggressive adult brain cancer—announced today the appointments of its first Senior Fellows: ... supporting the organization’s initiatives and overall vision. , "Senior Fellows are more than ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... ... R3 International is now offering stem cell therapy for Alzheimers dementia in ... the patient's condition, treatment may be offered IV, intrathecal or with a combination. , ... dementia, and the incidence continues to increase as individuals live longer. There is no ...
(Date:7/1/2020)... N.C. (PRWEB) , ... June 29, 2020 , ... ... reported year to date growth of 40% in 2020, despite many obstacles created ... technology, MedShift aims to increase revenue for its partnered medical practices and medical ...
(Date:7/1/2020)... Colo. (PRWEB) , ... June ... ... of expert tissue data insights, today announced that the launch of a ... results along with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the ... vaccine or drug treatment. In an effort to better understand the cellular responses ... world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 approved and ...
Breaking Biology Technology:
Cached News: