HOME >> BIOLOGY >> NEWS
Bio-X grant recipient explores link between molecular chaperones and serious diseases

``You`ve got to know when to fold `em,`` says the famous country western song.

Sound advice for playing poker - or making proteins.

It turns out that nearly every molecule of protein produced in your body has to be folded into a specific, three-dimensional shape in order to function properly. Because it translates the linear genetic code into three dimensions, protein folding has been called the second, and more intractable, half of the genetic code.

X-rays of the protein hemoglobin, for example, reveal a complex molecule that resembles a ball of twisted ribbon - a unique shape that allows hemoglobin to carry oxygen through the bloodstream. If the molecule is folded incorrectly, oxygen will not be delivered.

The human body produces thousands of proteins, each with a distinct function and shape. Some resemble convoluted pretzels, while others are woven into intricate braids.

Biologists used to believe that every protein molecule folded spontaneously as it was being assembled inside the living cell, but recent studies show that many proteins actually need help getting into shape.

Enter molecular chaperones.

Discovered just over a decade ago, chaperones are small proteins that help bigger ones fold and assemble. Some chaperones literally serve as escorts, guiding and twisting newborn proteins into their correct shape.

``No one expected that a cell would require special machinery for protein folding,`` says molecular biologist Judith Frydman, ``but what we are finding is that almost every interesting protein needs a chaperone.``

Frydman, an assistant professor of biological sciences, is one of a handful of international researchers whose work has led to new discoveries about molecular chaperones and their vital role in sustaining life.

``Chaperones prevent proteins from folding prematurely or sticking to debris inside the cell,`` she says. ``Without chaperones, some cells get very, very sick.``

Fryd
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
3-Oct-2000


Page: 1 2 3 4 5

Related biology news :

1. Bio-X symposium will be held at the Clark Center on July 31
2. Bio-X to fund 21 new interdisciplinary research projects
3. Bio-X awards $3 million in grants for imaginative interdisciplinary research and education projects
4. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
5. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
6. Florida Tech earns $50,000 grant to create coral database
7. $7.5 Million grant to Yale researchers for role of viruses in cancer
8. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
9. $2.7 million grant to support creation of virtual zebrafish atlas
10. Brown ecologist garners major National Science Foundation grant
11. Ecology of infectious diseases grants awarded

Post Your Comments:
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/13/2015)... 2015 According to a ... Market Forecast & Opportunities, 2020", the global biometrics market ... 14% till 2020. The biometrics market is garnering ... and review of biometric management systems. The constant ... with greater efficiency, are resulting in increasing installation ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
(Date:4/20/2015)... , April 20, 2015 ... Targeting Supramolecular Therapeutic Using the VOLVOX Platform - To ... -  Supramolecular Assembly of Antibody-drug Conjugates ... Payload - Presented on Sunday, Apr 19, 1:00 PM ... in supramolecular therapeutic program, today announced that the company,s ...
(Date:4/20/2015)... 20, 2015 Global Stem Cells ... Meeting 2015, an annual gathering of aesthetic medicine experts ... is scheduled to introduce the company’s brand new training ... adipose-derived stem cell techniques. , The course is ... in the aesthetic field, including facial aging caused by ...
(Date:4/17/2015)... 17, 2015 Reed Technology and ... regulatory data management, preparation, and submission to the U.S. ... of a new Lot Distribution Report (LDR) service for ... remain compliant with the FDA’s new rule on electronic ... to monitor the volume and timing of particular biologics ...
(Date:4/17/2015)...  US-Australian drug discovery company, Novogen, today announced ... with the Feinstein Institute for Medical Research (,Feinstein ... to collaborate with the objective of developing effective ... brings together the drug discovery expertise of Novogen ... Feinstein Institute in neurosciences and oncology. ...
Breaking Biology Technology:Invictus Oncology Announces Two Posters to be Presented Describing its Platform Technology on Supramolecular Therapeutics at the American Association for Cancer Research Annual Meeting, 2015 2Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal 2Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal 3Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6
Cached News: