HOME >> BIOLOGY >> NEWS
Bio-X grant recipient explores link between molecular chaperones and serious diseases

``You`ve got to know when to fold `em,`` says the famous country western song.

Sound advice for playing poker - or making proteins.

It turns out that nearly every molecule of protein produced in your body has to be folded into a specific, three-dimensional shape in order to function properly. Because it translates the linear genetic code into three dimensions, protein folding has been called the second, and more intractable, half of the genetic code.

X-rays of the protein hemoglobin, for example, reveal a complex molecule that resembles a ball of twisted ribbon - a unique shape that allows hemoglobin to carry oxygen through the bloodstream. If the molecule is folded incorrectly, oxygen will not be delivered.

The human body produces thousands of proteins, each with a distinct function and shape. Some resemble convoluted pretzels, while others are woven into intricate braids.

Biologists used to believe that every protein molecule folded spontaneously as it was being assembled inside the living cell, but recent studies show that many proteins actually need help getting into shape.

Enter molecular chaperones.

Discovered just over a decade ago, chaperones are small proteins that help bigger ones fold and assemble. Some chaperones literally serve as escorts, guiding and twisting newborn proteins into their correct shape.

``No one expected that a cell would require special machinery for protein folding,`` says molecular biologist Judith Frydman, ``but what we are finding is that almost every interesting protein needs a chaperone.``

Frydman, an assistant professor of biological sciences, is one of a handful of international researchers whose work has led to new discoveries about molecular chaperones and their vital role in sustaining life.

``Chaperones prevent proteins from folding prematurely or sticking to debris inside the cell,`` she says. ``Without chaperones, some cells get very, very sick.``

Fryd
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
3-Oct-2000


Page: 1 2 3 4 5

Related biology news :

1. Bio-X symposium will be held at the Clark Center on July 31
2. Bio-X to fund 21 new interdisciplinary research projects
3. Bio-X awards $3 million in grants for imaginative interdisciplinary research and education projects
4. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
5. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
6. Florida Tech earns $50,000 grant to create coral database
7. $7.5 Million grant to Yale researchers for role of viruses in cancer
8. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
9. $2.7 million grant to support creation of virtual zebrafish atlas
10. Brown ecologist garners major National Science Foundation grant
11. Ecology of infectious diseases grants awarded

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: