BioNumerik & Grelan present data on novel chemoprotecting agent

Orlando, FL, May 21, 2002 BioNumerik Pharmaceuticals, Inc. and Grelan Pharmaceutical Co., Ltd. today announced the presentation of results from a phase 1 clinical study of the novel investigational drug BNP7787 at the 38th Annual Meeting of the American Society of Clinical Oncology (ASCO) held in Orlando this week.

BNP7787 has so far demonstrated an impressive safety profile, commented Hashime Kanazawa, Ph.D., Executive Vice President and Chief Operating Officer of Grelan. Although this study was not designed to demonstrate tumor response we are encouraged by observations of an apparently high tumor response rate.

The data presented is derived from a Japanese Phase 1 clinical trial of BNP7787 in patients with advanced non-small cell lung cancer receiving paclitaxel and cisplatin. The trial was designed to evaluate the safety and pharmacokinetics of BNP7787 in order to establish a clinically recommended dose and to assess the effects of BNP7787 on paclitaxel and cisplatin combination therapy. No severe nerve damage (Grade 3 or Grade 4) was observed in any of the patients treated in the trial. In addition, of the twenty-one patients receiving chemotherapy, nine experienced a partial tumor remission (greater than or equal to a 50% reduction in tumor size) after two cycles of treatment with BNP7787 with paclitaxel and cisplatin. Eight additional patients experienced no progression (stable disease) while on therapy.

The neurotoxic effects of chemotherapies such as taxanes and platinum based drugs can seriously limit their effective use for the treatment of cancer, said Frederick H. Hausheer, M.D., Chairman and Chief Executive Officer of BioNumerik. These are promising results for BNP7787. We look forward to working with Grelan to initiate pivotal trials in Japan later this year.

BNP7787 is a novel chemoprotecting agent aimed at preventing common and serious side effects associated with taxane and platinum drugs, which are widely u

Contact: Ruey-Li Hwang
415-677-4455 x209
Noonan/Russo Communications

Page: 1 2

Related biology news :

1. DFG presents the 2004 MAK and BAT value lists
2. Presidential Recognition Awards presented at the 2004 AIUM Annual Convention
3. National study shows dog and cat allergens are universally present in U.S. homes
4. VIB presents its annual results at BIO2004 in San Francisco
5. White House lauds Physiological Society for mentoring underrepresented minorities in biomedicine
6. AACR awards scholarships to minority and underrepresented scientists
7. Steroid-coated DNA represents new approach to gene delivery
8. Inherent mistrust of research institutions limits minority representation
9. ASH presents advocacy awards to Sen. Dianne Feinstein and Claude Lenfant, M.D.
10. Max Planck Research awards 2003 presented
11. President Bush to present DuPont with National Medal of Technology

Post Your Comments:

(Date:7/10/2020)... ... , ... Today CJ BIO announced the first in a series of Food ... phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range ... 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual ...
(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... building awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced ... Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and ...
(Date:6/23/2020)... MILTON KEYNES, England (PRWEB) , ... June 23, ... ... operations in Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and ... rapid response project to support testing operations in the fight against the COVID-19 ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
Breaking Biology Technology:
Cached News: