HOME >> BIOLOGY >> NEWS
Biochemists Gain Crystal-Clear Insight into 'Ancient' Enzyme

y contacting the pre-tRNA. This is really a very different mechanism for what these proteins do," said Fierke.

The Duke researchers performed chemical experiments that confirmed this contact, producing altered versions of the protein that would chemically cross-link with the RNA in the cleft, allowing them to unequivocally determine that the protein was holding the RNA.

The Duke researchers also are tinkering with the protein's structure to explore a potential third key RNA binding region on the protein that may help the RNA of the ribonuclease P grab magnesium atoms that it needs to function optimally.

Such findings may offer intriguing insights into how the machinery of living cells first evolved, Fierke said.

"We really didn't expect such a role for the protein," she said. "And, if it turns out to be true, one could speculate that one of the reasons life evolved from an RNA-dependent world to a protein-dependent world is that the RNA required magnesium to do anything. And RNA is not particularly good at forming specific metal binding sites, whereas proteins are particularly good."

The biochemists' work might offer new targets for antibiotics, since ribonuclease P is essential for making all tRNAs, and since the bacterial enzyme is different from the enzyme in higher organisms. Thus, both the Duke and University of Pennsylvania groups propose to design inhibitor compounds that will block some aspect of the critical contacts among the protein, the RNA portion of the ribozyme, and the pre-tRNA.

"There are a great many places one could target to thwart this enzyme," Fierke said.


'"/>

Contact: Dennis Meredith
Dennis@dukenews.duke.edu
919-681-8054
Duke University
14-May-1998


Page: 1 2 3

Related biology news :

1. Insight into transplant rejection might lead to novel prevention therapies
2. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
3. Insights gained from molecular modeling may lead to better insecticides
4. Nerac.com and Infinata partner to offer BioPharm Insight(TM) Resource
5. While the homeland is on alert, Technical Insights provides indispensable technology information
6. Insight into the genetic pathways that drive segmentation like clockwork
7. New Insight into cervical cancer development: turning it up a notch
8. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
9. UCSF-Led Team Offers New Insight Into Neurological Basis Of Dyslexia
10. New Insights About Good Cholesterol
11. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Biochemists Gain Crystal Clear Insight into Ancient Enzyme

(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
(Date:5/27/2015)... Md. , May 27, 2015  Northwest Biotherapeutics, ... company developing DCVax® personalized immune therapies for cancer, announced ... Technical Officer of the Company, will be making an ... Meeting in Chicago on Saturday, ... at the Industry Expert Theater in McCormick Place. ...
(Date:5/27/2015)...  US-Australian drug discovery and development company, Novogen Limited (ASX: ... present at the Brain Tumor Biotech Summit 2015, being held ... 2015. The venue is the Lennox Hill Hospital, East 76 ... The Brain Tumor Biotech Summit brings together the nation,s ... investment community to promote innovative new therapies for brain tumors.  ...
(Date:5/27/2015)... , May 27, 2015 ­ Caris Life ... promise of precision medicine, today announced it has appointed ... a center of excellence site in the Caris Centers ... Levine Cancer Institute is one of the largest ... than 11,000 new cancer patients annually. Derek Raghavan ...
(Date:5/26/2015)... WORMS, GERMANY – May 26, 2015 ... announces that its manufacturing facility in Worms, Germany ... EXCiPACTâ„¢, an independent organization that certifies manufacturers, suppliers, ... All three Grace facilities that produce its SYLOID® ... have now received GMP certification, following the Curtis ...
Breaking Biology Technology:NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3Novogen to Present at Brain Tumor Biotech Summit 2015 2Novogen to Present at Brain Tumor Biotech Summit 2015 3Novogen to Present at Brain Tumor Biotech Summit 2015 4Novogen to Present at Brain Tumor Biotech Summit 2015 5Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 2Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 4CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
Cached News: