HOME >> BIOLOGY >> NEWS
Biological cause of one form of blindness identified by SLU researchers

ST. LOUIS - Saint Louis University researchers have discovered the cause of one form of retinitis pigmentosa, a type of genetically inherited blindness. The research, which will be published Tuesday in the April 27 Proceedings of the National Academy of Sciences (PNAS), opens the door to the development of new treatments.

The research was based on genetic information provided by several blind members of a South African family. The laboratory of William Sly, M.D., chair of the department of biochemistry at Saint Louis University School of Medicine, collaborated on the research with scientists from UCT/Groote Schuur Hospital in South Africa. Further evidence in support of their research was provided by Dr. Kang Zhang at the University of Utah.

The research began when a "gene hunt" involving five large families led the South African scientists to discover a genetic mutation not previously known to be involved in retinitis pigmentosa. The discovery was unusual because this gene was expressed only in the kidney and in micro-capillaries such as the capillaries beneath the eye, and not in the retina itself; typically, genes involved in retinal diseases are expressed only in the retina.

After making the discovery, the South African researchers contacted Dr. Sly's lab, which had done extensive independent work with the gene. Dr. Sly's group set out to discover how the mutation could cause blindness.

They discovered it interferes with a process necessary for healthy cell development. The mutation causes a secretory protein in the capillaries beneath the retina to improperly "fold," a process necessary for healthy cell development. When the proteins fail to fold quickly enough, a response is triggered that can cause the cells to die.

"These capillaries nourish the retina," Dr. Sly said. "When they die, the retina dies along with them."

Understanding this mechanism should lead directly to the develop
'"/>

Contact: Matt Shaw
shawmr@slu.edu
314-977-8018
Saint Louis University
28-Apr-2004


Page: 1 2

Related biology news :

1. Biological oceanographers examine regime shifts in complex marine ecosystems
2. Biological computer diagnoses cancer and produces drug in a test tube
3. Biological trick reveals key step in melatonins regulation
4. Journal of Gerontology: Biological Sciences to offer forum
5. Biological clock more influenced by temperature than light
6. Systematics at a Crossroads: Biological and Philosophical Arguments
7. Biological and chemical agents in terrorism examined at AAN Annual Meeting
8. Biological Challenges to Humanity: Emerging and Re-emerging Pathogens
9. Biological evidence can persuade people to change unhealthy habits
10. Biological warfare: an emerging threat in the 21st century
11. Biological clock gene in bees found to have another function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... ... Experiential tourism, a trend encompassing culinary travel, cultural exploration and activity-based travel ... according to a recent report by Skift, a media company for the travel industry, ... are wanting their journeys to be authentic and unique, and good cuisine has shown ...
(Date:5/21/2019)... , ... May 20, 2019 , ... ... health care field, today announced a 96.15% pass rate for first-time test takers ... This surpasses the national average of 76.43% by nearly 20 points. , ...
(Date:5/14/2019)... ... 14, 2019 , ... IMMUNE 3D®, a privately held biotechnology ... of autoimmunity, fibrosis and skin immunology. In addition, the company will leverage its ... efforts. , IMMUNE 3D®’s proprietary platform aims to study factors that affect ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... ... April 30, 2019 , ... By ... USA Inc. has demonstrated its ability to provide various services and products ... enhance customer satisfaction through the effective implementation of its quality management system, ...
(Date:5/2/2019)... ... , ... Boston Robotic Hair Restoration announces the most advanced ... of painful hair transplant procedures. Boston Robotic Hair Restoration offers the newest, state-of-the-art ... solution to offer a minimally invasive procedure. With the ARTAS® iX robotics, patients ...
(Date:4/16/2019)... (PRWEB) , ... April 16, 2019 , ... ... Blue Sources and their project partner, the U.S. Army Center for Environmental Health ... Aquatic Biomonitor Through Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company located at ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... locked into multiple agreements to help companies advance their innovations to clinical ... ranging from synthetic biology companies that are gene editing therapeutic cells for ...
Breaking Biology Technology:
Cached News: