HOME >> BIOLOGY >> NEWS
Biologists ID defense mechanism of leading fungal pathogen

HOUSTON, June 25, 2004 -- Molecular biologists at Rice University have discovered a key defense mechanism that the yeast Candida albicans uses against attack by the human immune system. This chink in the armor of Candida, the most common human fungal pathogen, could be exploited with new drugs for both lethal and non-lethal Candida outbreaks, including vaginal yeast infections and thrush.

In the study, researchers ran side-by-side comparisons between Candida and baker's yeast -- an organism that doesn't typically infect humans -- in order to find the genes that Candida uses to protect itself against nitric oxide, or NO. Human immune cells give off NO to slow the growth of yeast colonies. The study, published in this month's issue of the journal Eukaryotic Cell, isolated one gene that appears to play a critical role in Candida's NO defense.

The researchers determined that Candida, unlike baker's yeast, is able to sense the presence of NO and ramp up its defenses. They are currently trying to determine which chemical signals Candida uses to detect the presence of NO.

"Baker's yeast and Candida both have the gene to make NO-scavenging enzymes, but Candida has three copies, and it alone has a mechanism to react to increased NO levels by producing more NO-scavengers," said lead researcher Mike Gustin, associate professor of biochemistry and cell biology. "If we can identify the signaling mechanism it uses, that would give us one more useful target for new drug therapies."

Candida is common in humans. It's estimated that 70 percent of people have Candida colonies in their intestines, mouths or on their skin. In most cases, the organism is commensal, meaning it does not harm people, even though it depends upon them for food. However, colonies of Candida sometimes grow too large, as happens in the case of yeast infections. While not life-threatening, vaginal yeast infections are a common and painful problem for a significant percentage of Ame
'"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
25-Jun-2004


Page: 1 2 3

Related biology news :

1. Biologists deciphering complex lemur scent language
2. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
3. Biologists uncover genetic links to broad range of human disorders resulting from cilia dysfunctions
4. American Society of Plant Biologists offers developing nations free access to science journals
5. Open access initiative from the Company of Biologists
6. Biologists find unexpected rapid evolution in Caribbean lizards
7. American Society of Plant Biologists Annual Meeting 2003
8. Biologists raising baby loggerhead turtles for conservation find disturbing gender trend
9. Biologists new experiment may vindicate Darwin
10. Biologists take new look at metabolism
11. Biologists track down central cause of lupus

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Biologists defense mechanism leading fungal pathogen

(Date:5/21/2015)... 2015 The Sync Project™ , a ... health, today announced a collaborative partnership with Berklee,s ... center on collaboration on original research, joint course development ... the collaboration, The Sync Project and BerkleeICE are exploring ... in the 2015-2016 academic year.  The ...
(Date:5/19/2015)... DUBLIN , May 19, 2015 /PRNewswire/ ... ) has announced the addition of the  ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A ... provides an in-depth analysis of the current ... introduction of gene-based tests, their working principles ...
(Date:5/11/2015)... , May 11, 2015  Through a well-rounded UAS delegation ... had a strong showing at AUVSI,s Unmanned 2015 conference ... of Ohio,s UAS industry met with ... from all points along the UAS ecosystem. ... (DDC) Vice President for Aerospace Rich Knoll . "If ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Global Genetic Testing Market Outlook 2018 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
(Date:5/21/2015)... As part of its philanthropic partnership with Banner ... funded a $3.25 million project to relocate and equip ... up-to-date features and technology. , The new pharmacy is ... members will begin moving from the current location to ... , The current pharmacy has been using a ...
(Date:5/21/2015)... 2015 Tunnell Consulting, Inc. ... as senior statistician and Principal, a position to which ... the management and analysis of complex and large data ... , “We’re delighted to have Julia join the Tunnell ... said Dr. Philippe Cini, Group Vice President and leader ...
(Date:5/20/2015)... , May 19, 2015 Research and Markets ... of the "Global Cell Therapy Market Outlook 2020 ... of cell therapy in tissue and regenerative medicine is ... no other options which could help in the growth ... this segment but they are unable to form new ...
(Date:5/20/2015)... CT (PRWEB) May 20, 2015 Agricultural ... 10th anniversary of its acquisition of Tiger-Sul. Since ... Enersul (Calgary Alberta, Canada) in May 2005, H.J. Baker ... to build it into a comprehensive portfolio of product ... strength of H.J. Baker and the innovation of Tiger-Sul, ...
Breaking Biology Technology:Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3
Cached News: