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Bionumerik reports data on two novel supercomputer engineered anticancer agents

San Francisco, CA; April 6, 2000 -- BioNumerik Pharmaceuticals, Inc. presented data at the 91st Annual Meeting of the American Association of Cancer Research (AACR) being held in San Francisco this week on two novel high performance computer engineered agents that have been designed to help address common and important unmet needs in cancer therapy. BioNumerik's BNP7787 is a unique chemoprotectant utilized to prevent the common and often severe toxicities associated with platinum and taxane administration without inhibiting the antitumor activity of these agents. BioNumerik's Karenitecin BNP1350 is a silicon-containing camptothecin-like agent that has demonstrated potent antitumor activity in several preclinical models including human cancer cell lines and animal bearing human tumor models. Karenitecin has been specifically crafted to overcome known problems of commercially available camptothecins such as lack of oral bioavailability, lactone instability, toxicity and drug resistance.

BNP7787
Further data from animal and laboratory studies was presented at AACR that establishes the ability of BNP7787 to protect against platinum and taxane induced toxicities. It has been determined that BNP7787 and its metabolites selectively conjugate with monohydrated platinum species which is thought to be the overriding mechanism for platinum toxicity. This unique activity of platinum detoxification by BNP7787 was elucidated through the marriage of high performance computing and application of basic sciences.

An ongoing Phase 1 study of BNP7787 at doses of 41g/m2 in Europe and 27.6g/m2 in the U.S. has demonstrated excellent safety results with only 3 out of 46 patients treated with standard doses of cisplatin +/- paclitaxel experiencing clinically significant grade 2 nerve damage (neurotoxicity). This number is substantially less than the expected number of patients with grade 2 nerve damage, b
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Contact: Page Sargisson
p.sargisson@noonanrusso.com
415-677-4455 x 229
Noonan/Russo Communications
5-Apr-2000


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