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Biosensor-regulated gene therapy reduces heart attack damage in mice

Tampa, FL (April 6, 2004) -- A novel gene therapy that responds specifically to oxygen-starved heart muscle may protect against further injury following a heart attack, a study by University of South Florida cardiovascular researchers found.

Their findings are reported in the April 2004 issue of the journal Hypertension.

M. Ian Phillips, PhD, DSc, and his team at the USF College of Medicine and All Children's Hospital Research Institute designed a kind of oxygen-sensitive biosensor that turns on protective genes when signs of oxygen deprivation indicate a heart attack and turns the genes off once blood flow restores adequate oxygen levels to the heart. Dr. Phillips, principal investigator; Yao Liang Tang, MD, lead author; and colleagues showed that this biosensor-regulated gene therapy protected heart muscle cells in mice with heart attacks from further injury.

Dr. Phillips and Dr. Tang envision administering such a therapy after a first heart attack to limit initial damage and prevent future attacks. While much work remains to test and refine such a therapy, Dr. Phillips said, this new concept might eventually be an alternative to stents and bypass surgery.

People who suffer one heart attack are at higher risk for subsequent attacks. Often lack of blood flow to the heart muscle, known as cardiac ischemia, does not cause pain or other symptoms. This asymptomatic or "silent" ischemia can lead to a second or third heart attack without prior warning.

"Repeated bouts of myocardial ischemia cause cumulative tissue damage in the heart vessels that can lead to a fatal heart attack," said Dr. Phillips, USF vice president for research and professor of physiology and biophysics. "Therefore, what patients need is a gene therapy strategy that acts in the heart and switches on or off, so that the therapeutic protein is produced only where and when it is needed."

"One of the exciting aspects of the approach, described by Tang et
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Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
6-Apr-2004


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