HOME >> BIOLOGY >> NEWS
Blasting antibodies with lasers provides direct way of measuring their flexibilities

A group of scientists at The Scripps Research Institute (TSRI) and San Diego Supercomputer Center at the University of California at San Diego (UCSD) have used a powerful laser in combination with innovative quantum mechanical computations to measure the flexibility of mouse antibodies.

The new technique, described in an upcoming issue of the journal Proceedings of the National Academy of Sciences, is significant because protein flexibility is believed to play an important role in antibody-antigen recognition, one of the fundamental events in the human immune system.

"This is the first time anybody has ever gone into a protein and experimentally measured the frequency of protein vibrations in response to an applied force," says Floyd Romesberg, assistant professor in the Department of Chemistry at The Scripps Research Institute, who led the study.

"Our results show that the motions of the antibody-antigen complexes can range over four orders of magnitude, from tens of femtoseconds to hundreds of picoseconds," says co-author Kim K. Baldridge, Ph.D., director of Integrative Computational Sciences at the San Diego Supercomputer Center and an adjunct professor of Chemistry at UCSD. "This is evidence of a general mechanism of antigen-antibody interactions--which range from rigid to flexible," she adds.

Flexibility of Proteins

Protein flexibility is an important concept in biology because of its role in protein-protein and protein-ligand recognition. One of the longest running debates in molecular recognition is how proteins recognize and bind to other molecules--whether it resembles putting a key into a lock (the lock and key model) or catching a baseball in a catcher's mitt (the induced fit model).

There are lots of ideas about mechanisms of antigen recognition postulated in the literature, but what the debate comes down to is really a question of flexibility. How flexible are proteins?

Unfortunately, fle
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
17-Dec-2002


Page: 1 2 3

Related biology news :

1. Researchers find clues about how antibodies specialize
2. Second generation targeted antibodies - Its all in the binding
3. Anti-interferon beta antibodies in MS care: A consensus
4. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
5. Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
6. Bodys own antibodies may drive new strains of HIV
7. Growing human antibodies in algae
8. Ozone produced by antibodies during bacterial killing and in inflammation
9. Artificial antibodies created by new molecular imprinting process
10. Human antibodies against spores found by researchers suggest new tool to detect and treat anthrax
11. Scientists at The Scripps Research Institute discover a previously unknown role for antibodies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/6/2017)... March 6, 2017 Mintigo , ... today announced Predictive Sales Coach TM , its ... sales intelligence into Salesforce. This unique AI application ... sales organizations with deep knowledge of their customers ... intelligent engagement. Predictive Sales Coach extends Mintigo,s existing ...
(Date:3/2/2017)... Summary This report provides all the information ... partnering interests and activities since 2010. Download the ... Deals and Alliance since 2010 report provides an in-depth ... world,s leading life sciences companies. On demand ... of the most up to date deal and company ...
(Date:3/2/2017)... Australia , March 2, 2017 Australian ... Ltd (ASX: CYP), has signed an agreement with ... from the Monash Biomedicine Discovery Institute and Department of ... to conduct a further preclinical study to support the ... treatment of asthma.  Asthma is a ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... , ... March 29, 2017 , ... ... comprising multiple separable adhesive layers, as issued by the U.S. Patent & Trademark ... it applies to combining electronics and health monitoring. This invention will be critical ...
(Date:3/29/2017)... Pa. , March 29, 2017 Patients ... which is why CSL Behring awards Local Empowerment for ... rare disease patient groups. These groups tackle complex legislative ... heard on Capitol Hill and in statehouses across the ... the community-based grant was awarded to New England Hemophilia ...
(Date:3/29/2017)... and HILDEN, Germany , March 29, 2017 ... PRIME STANDARD: QIA) today announced the U.S. launch of its ... which was cleared by the U.S. Food and Drug Administration as a qualitative ... genomic DNA extracted from EDTA whole blood.* ... The ipsogen JAK2 assay is processed on QIAGEN,s Rotor-Gene ® ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - Last year,s petition to ... not the only efforts active to generate awareness on the importance ... pharmaceutical drugs in the healthcare market place. ... Earlier this month Health Advance ... distributor of pharmaceutical and nutritional products, announced its endeavors on this ...
Breaking Biology Technology:
Cached News: