HOME >> BIOLOGY >> NEWS
Blood vessels found to signal chain of destruction in bone diseases

Biologists at Washington University in St. Louis have discovered a mechanism in blood vessels that opens the door for bone loss in such diseases as rheumatoid arthritis, periodontal disease, osteoporosis, tumor-associated bone loss, or artificial implant loosening.

Patricia Collin-Osdoby, Ph.D., research associate professor of biology in Arts & Sciences at Washington University, and Philip Osdoby, Ph.D., professor of biology in Arts & Sciences, and Linda Rothe, Washington University research associate, have for the first time shown that blood vessels at inflamed sites where bone loss is occurring create signals that set into motion a cascade of events leading to local bone destruction.

When an area of tissue in or near bone becomes inflamed, key molecules called cytokines are locally produced and increase in the bloodstream. Studying human tissue and cell samples, the Osdobys have shown that two key inflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), signal the endothelial cells of blood vessels and capillaries to make and display on their cell surface a molecule called RANKL. RANKL is the critical signal that tells the body to make and activate bone-degrading cells called osteoclasts. After osteoclasts take bone away, osteoblasts go back in and add new bone. Normally, this bone remodeling, which is associated with a blood vessel or capillary at such sites, is a carefully balanced process. However, in persons with inflammatory bone disease, osteoclasts out-number and out-work the bone-forming osteoblasts, leading to weakened bone matrix, bone loss, and an increased risk of fracture. The Osdobys believe that inflamed blood vessels beckon cells to the region, and then initiate their development into highly active bone-degrading osteoclasts.

The researchers also found that in this biochemical chain of events, the blood vessels themselves make an antagonist molecule, osteoprotegerin (OPG), whic
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@aismail.wustl.edu
314-935-5272
Washington University in St. Louis
26-Jun-2001


Page: 1 2 3 4

Related biology news :

1. Blood pressure hormone may inhibit growth of lung cancer
2. Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
3. Blood banking systems improving in China, more progress needed
4. Blood proteins tied to inflammation
5. Bloodworms way with copper likely provides paradigm for new materials
6. Blood markers may reflect newborns potential of contracting HIV
7. Blood stem cells carry targeted genes
8. Blood vessels trigger development of the pancreas
9. Blood markers associated with autism and mental retardation
10. Blood test for diagnosing schizophrenia
11. Blood pressure-lowering DASH diet also reduces homocysteine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)... Oct. 4, 2017  GCE Solutions, a global clinical research organization ... document anonymization solution on October 4, 2017. Shadow is designed to ... comply with policy 0070 of the European Medicines Agency (EMA) in ... ... ...
(Date:6/30/2017)... , June 30, 2017 Today, ... developer and supplier of face and eye tracking ... Featured Product provider program. "Artificial ... innovative way to monitor a driver,s attentiveness levels ... from being able to detect fatigue and prevent ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... recipients of 13 prestigious awards honoring scientists who have made ... in a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition ...
(Date:10/9/2017)... Charlotte, N.C. (PRWEB) , ... October 09, 2017 , ... ... Purple announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and ... Dr. Stubbs was a member of the winning team for the 2015 Breakthrough Prize ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments ... consulting, Nanoscience Analytical offers a broad range of contract analysis services for ...
(Date:10/6/2017)... Boston, Mass. (PRWEB) , ... October 06, 2017 ... ... spotlight female entrepreneurship within the healthcare and technology sector at their fourth annual ... six panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early ...
Breaking Biology Technology:
Cached News: