HOME >> BIOLOGY >> NEWS
Blood vessels trigger development of the pancreas

Scientists have known that developing organs communicate with blood vessels via chemical signals to ensure that they receive the proper blood supply to sustain growth. Now, researchers have discovered that blood vessels themselves can send signals to the pancreas that trigger its development. The finding provides the first glimpse of a new type of biochemical signaling pathway that may prevent the pancreas, and possibly other organs, from developing until a blood-supply pipeline is in place.

According to the researchers, the source of the blood vessel signal may prove useful to scientists who are hoping to guide the differentiation of embryonic stem cells into pancreatic islet cells, the insulin-producing cells that are depleted in people who have type I diabetes. The discovery was published September 28, 2001, in the journal Science, as part of the Science Express Web site.

"Other biologists might already have thought of the possibility of such signaling, but it was definitely a surprise to me," said Melton, a Howard Hughes Medical Institute investigator at Harvard University. According to Melton, insights from histological studies provided the initial evidence that led them to search for blood vessel signaling.

"When we used histological sections to examine how the pancreas develops, what jumped out was that we could never find any evidence for pancreas development or differentiation when there wasnt a blood vessel touching it," he said. "Also, it has been long known that in mice the pancreas develops by initially forming three buds, which are subsequently reduced to two. These remaining two buds fuse to form the whole pancreas. Wed always been puzzled about why the third bud disappears, and our examinations showed that this bud invariably loses its contact with a blood vessel. Taken together, these studies indicated to us that pancreatic development is closely linked with the presence or absence of blood vessels."

Melton and collea
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
27-Sep-2001


Page: 1 2 3

Related biology news :

1. Blood pressure hormone may inhibit growth of lung cancer
2. Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
3. Blood banking systems improving in China, more progress needed
4. Blood proteins tied to inflammation
5. Bloodworms way with copper likely provides paradigm for new materials
6. Blood markers may reflect newborns potential of contracting HIV
7. Blood stem cells carry targeted genes
8. Blood vessels found to signal chain of destruction in bone diseases
9. Blood markers associated with autism and mental retardation
10. Blood test for diagnosing schizophrenia
11. Blood pressure-lowering DASH diet also reduces homocysteine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: