Blood vessels trigger development of the pancreas

gues Eckhard Lammert and Ondine Cleaver did three types of experiments that provided additional evidence that blood vessel endothelial cells transmit signals to embryonic endodermal cells that develop into tissues such as the pancreas.

In cell culture studies, Melton and his colleagues found that isolated, cultured endoderm cells showed no signs of becoming pancreatic cells as they grew. When the scientists added cells from the dorsal aorta -- a vessel that lies next to those cells in the developing embryo -- the endoderm cells began expressing insulin and the gene, Pdx1, which is a known marker of pancreatic differentiation.

In experiments using frog embryos, the scientists found that when they removed blood vessels that were adjacent to pancreatic tissue, the embryos did not show normal expression of genes or insulin production that would be characteristic of normal pancreas differentiation.

Finally, the scientists created transgenic mice in which the gene VEGF164, which triggers blood vessel development, was overexpressed. In these studies, the scientists found that a dramatic increase in blood vessel endothelial tissue accompanied a similar increase in pancreatic islet cells. The researchers also found insulin-producing cells in the stomachs of the mice an area where such cells would not normally appear. The three lines of evidence warrant a rethinking of the role of blood vessels in organ development, said Melton.

"The fact that all tissues and organs in the body need blood has led many biologists, including myself, to consider blood vessels as tubing that provides sustenance for the body," he said. "But beyond that, there are a special set of organs or tissues in the body that use blood to serve their basic functions. These include hormone-secreting endocrine glands, lungs, kidneys, the liver and the pancreas.

"So, these organs must arrange for intimate contact with vessels," he said. "To do this, they could develop fir

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Blood pressure hormone may inhibit growth of lung cancer
2. Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
3. Blood banking systems improving in China, more progress needed
4. Blood proteins tied to inflammation
5. Bloodworms way with copper likely provides paradigm for new materials
6. Blood markers may reflect newborns potential of contracting HIV
7. Blood stem cells carry targeted genes
8. Blood vessels found to signal chain of destruction in bone diseases
9. Blood markers associated with autism and mental retardation
10. Blood test for diagnosing schizophrenia
11. Blood pressure-lowering DASH diet also reduces homocysteine

Post Your Comments:

(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life ... and compliance, announces a new solution to manage regulated workloads on Microsoft Azure. ... their technology stack complies with FDA and global regulations. USDM's new managed service ...
(Date:7/18/2020)... ... 17, 2020 , ... Commercial launch readiness is a critical stage in a ... cure or vaccine, the global economic downturn will only increase price pressures overall for ... and capturing full value from every product launch is critical. However, history shows that ...
(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass webinars, ... revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory foods ... AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & Food ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... WOODLANDS, Texas (PRWEB) , ... August 06, 2020 ... ... therapy and DNA vaccine industries, announces it has closed on the purchase of ... Technology Park in Conroe, TX and includes over 21 acres in the initial ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery ... of a great surgery is only the beginning of a successful study, while protecting ... , Join Brad Gien, Global Head of Surgery from Envigo in a ...
Breaking Biology Technology:
Cached News: