HOME >> BIOLOGY >> NEWS
Blooming health thanks to a frog

As published in the October 15th issue of Genes & Development, Dr. Hong Yan and his team at Fox Chase Cancer Center in Philadelphia detail their use of frogs to investigate how the gene defective in patients with Bloom's Syndrome works. Bloom's Syndrome is associated with the development of tumors early in life, usually in the twenties. Bloom's Syndrome is a rare genetic disease which is most frequently found among Ashkenazi Jews. These patients are predisposed to develop all types of the cancer. Understanding the molecular mechanisms beneath Bloom's Syndrome is an important goal to help to fight cancer.

The gene defective in Bloom's Syndrome enables additional mutations to occur. This gene belongs to the helicases, a class of proteins known to unwind double stranded DNA during replication and repair. In order to identify the exact role of this protein, Dr. Yan and colleagues turned to the species Xenopus, a frog firmly established as a biological model system. They used extracts from Xenopus eggs to reconstitute a cell-free system of DNA replication. After identifying the frog version of the Bloom's Syndrome protein, the team used specific antibodies to remove the protein from the system. They discovered that the Bloom's Syndrome protein is essential for DNA replication in Xenopus. It is likey that the protein will have the same function in humans. Turning to a frog sometimes really leads to royal results.


'"/>

Contact: Nora Poppito
poppito@cshlorg
Cold Spring Harbor Laboratory
14-Oct-2000


Page: 1

Related biology news :

1. New IU Bloomington life sciences building gets a name
2. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
3. Chemical signals health of brain cells Symposium
4. The birth of reproductive health: A difficult delivery
5. Ventilation in bars, casinos doesnt control health risk for hospitality workers
6. Diabetics face fewer healthy food choices in some urban areas
7. Human health risks in space flight focus of research internships
8. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
9. Ottawas leadership in biomedical and health research has paid off
10. Oxygen sensing in worms may hold key to healthy blood pressure in humans
11. Make a splash for public health this summer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/6/2017)... , Jan. 5, 2017  Delta ID Inc., ... iris scanning technology for automotive at CES® 2017. Delta ... GNTX ) to demonstrate the use of iris scanning ... and authenticate the driver in a car, and as ... the driving experience. Delta ID and Gentex ...
(Date:12/22/2016)... VIEW, Calif. , Dec. 20, 2016  As part ... levels, 23andMe, the leading personal genetics company, recently released its ... Me . The book focuses on the topics of ... Next Generation Science Standards (NGSS) taught in elementary school classrooms ... second in a series by illustrator Ariana Killoran , ...
(Date:12/19/2016)... , España y TORONTO , 19 de diciembre ... Northern Biologics Inc. que permitirá el desarrollo acelerado de MSC-1, un ... en varios tipos de tumor en 2017, con múltiples sitios previstos ... ... clase con objetivo en el factor inhibidor de leucemia (LIF), una ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... 2017 , ... November Research Group, LLC, a global leader ... manufacturers and regulators, is proud to announce the worldwide release of PRIMO Mail. ... provide product vigilance departments with the flexibility and ease of use of a ...
(Date:1/19/2017)... 2017  ArmaGen, Inc., today announced that it ... chief executive officer, as well as a member ... ArmaGen more than 17 years of executive management ... biotherapeutics and pharmaceuticals. "Mathias is ... and skillset necessary to lead ArmaGen to its ...
(Date:1/19/2017)... Bethesda, MD (PRWEB) , ... January 18, 2017 ... ... for the National Institutes of Health (NIH) to update its Data Sharing Policy. ... a “scoreable” element of grant applications subject to the existing policy. AMIA recommended ...
(Date:1/19/2017)... ... , ... FireflySci Inc. is a go-getter type of company that continues to ... two main factors. The first is the amazing customer service that the FireflySci ... all around the world. , 2016 was a tremendous sales year for FFS and ...
Breaking Biology Technology:
Cached News: