HOME >> BIOLOGY >> NEWS
Blooming health thanks to a frog

As published in the October 15th issue of Genes & Development, Dr. Hong Yan and his team at Fox Chase Cancer Center in Philadelphia detail their use of frogs to investigate how the gene defective in patients with Bloom's Syndrome works. Bloom's Syndrome is associated with the development of tumors early in life, usually in the twenties. Bloom's Syndrome is a rare genetic disease which is most frequently found among Ashkenazi Jews. These patients are predisposed to develop all types of the cancer. Understanding the molecular mechanisms beneath Bloom's Syndrome is an important goal to help to fight cancer.

The gene defective in Bloom's Syndrome enables additional mutations to occur. This gene belongs to the helicases, a class of proteins known to unwind double stranded DNA during replication and repair. In order to identify the exact role of this protein, Dr. Yan and colleagues turned to the species Xenopus, a frog firmly established as a biological model system. They used extracts from Xenopus eggs to reconstitute a cell-free system of DNA replication. After identifying the frog version of the Bloom's Syndrome protein, the team used specific antibodies to remove the protein from the system. They discovered that the Bloom's Syndrome protein is essential for DNA replication in Xenopus. It is likey that the protein will have the same function in humans. Turning to a frog sometimes really leads to royal results.


'"/>

Contact: Nora Poppito
poppito@cshlorg
Cold Spring Harbor Laboratory
14-Oct-2000


Page: 1

Related biology news :

1. New IU Bloomington life sciences building gets a name
2. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
3. Chemical signals health of brain cells Symposium
4. The birth of reproductive health: A difficult delivery
5. Ventilation in bars, casinos doesnt control health risk for hospitality workers
6. Diabetics face fewer healthy food choices in some urban areas
7. Human health risks in space flight focus of research internships
8. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
9. Ottawas leadership in biomedical and health research has paid off
10. Oxygen sensing in worms may hold key to healthy blood pressure in humans
11. Make a splash for public health this summer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... Disappearing forests ... the lives of over 5.5 million people each year. Especially those living in larger ... startup Treepex - based in one of the most pollution-affected countries globally - decided ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
(Date:10/10/2017)... CA (PRWEB) , ... October ... ... a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today ... of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
Breaking Biology Technology:
Cached News: