HOME >> BIOLOGY >> NEWS
Blooming health thanks to a frog

As published in the October 15th issue of Genes & Development, Dr. Hong Yan and his team at Fox Chase Cancer Center in Philadelphia detail their use of frogs to investigate how the gene defective in patients with Bloom's Syndrome works. Bloom's Syndrome is associated with the development of tumors early in life, usually in the twenties. Bloom's Syndrome is a rare genetic disease which is most frequently found among Ashkenazi Jews. These patients are predisposed to develop all types of the cancer. Understanding the molecular mechanisms beneath Bloom's Syndrome is an important goal to help to fight cancer.

The gene defective in Bloom's Syndrome enables additional mutations to occur. This gene belongs to the helicases, a class of proteins known to unwind double stranded DNA during replication and repair. In order to identify the exact role of this protein, Dr. Yan and colleagues turned to the species Xenopus, a frog firmly established as a biological model system. They used extracts from Xenopus eggs to reconstitute a cell-free system of DNA replication. After identifying the frog version of the Bloom's Syndrome protein, the team used specific antibodies to remove the protein from the system. They discovered that the Bloom's Syndrome protein is essential for DNA replication in Xenopus. It is likey that the protein will have the same function in humans. Turning to a frog sometimes really leads to royal results.


'"/>

Contact: Nora Poppito
poppito@cshlorg
Cold Spring Harbor Laboratory
14-Oct-2000


Page: 1

Related biology news :

1. New IU Bloomington life sciences building gets a name
2. Genetic modification of linseed produces healthier omega 3 and 6 fatty acids
3. Chemical signals health of brain cells Symposium
4. The birth of reproductive health: A difficult delivery
5. Ventilation in bars, casinos doesnt control health risk for hospitality workers
6. Diabetics face fewer healthy food choices in some urban areas
7. Human health risks in space flight focus of research internships
8. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
9. Ottawas leadership in biomedical and health research has paid off
10. Oxygen sensing in worms may hold key to healthy blood pressure in humans
11. Make a splash for public health this summer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Blooming health thanks frog

(Date:8/20/2014)... Aug. 20, 2014 George E. Fox, a John and ... of Houston (UH), was named a fellow in the International ... , Fox is one of four members two ... chosen as fellows in 2014. Fellows are elected every ... more than 500 members from more than 20 countries, the ...
(Date:8/20/2014)... 158 pregnant teenagers in Rochester, NY, nearly half engaged ... ice, cornstarch, vacuum dust, baby powder and soap, and ... Moreover, such teens had significantly lower iron levels as ... , Pregnant teens, regardless of pica, are at higher ... deficiency and anemia. Low iron in pregnant teens raises ...
(Date:8/20/2014)... Cancer Institute (HCI) at the University of Utah have ... encodes BCR-ABL, the unregulated enzyme driving the blood cancer ... Society, nearly 6,000 new cases of CML will be ... tyrosine kinase inhibitors (TKIs), target BCR-ABL and are effective ... but control it in a way that allows patients ...
Breaking Biology News(10 mins):UH professor named fellow by International Astrobiology Society 2Pica in pregnant teens linked to low iron 2Blueprint for next generation of chronic myeloid leukemia treatment 2
(Date:8/20/2014)... Aug. 20, 2014 Clintrax Global, Inc., ... in Raleigh, NC , recently ... as Vice President of Administration. ... all corporate processes, including their alignment with company ... Brad worked as an HR executive, specializing in ...
(Date:8/20/2014)... of patented university inventions licensed to biotechnology firms ... commercialization. To open these roadblocks, the researchers suggest ... the discovery stage could lead to faster commercialization ... derived from discoveries made in university laboratories and ... during clinical trials, which have a high failure ...
(Date:8/20/2014)... school history lessons often have it that American Indians ... cough, chicken pox, influenza and tuberculosis brought to the ... estimates vary, about 20 million people lived in the ... of them were killed by European diseases., But new ... State University and Johannes Krause of the University of ...
(Date:8/20/2014)... in measuring vibrational motion of a single molecule with ... of a single molecule differs from the behaviour of ... at the University of California, Irvine, where post-doctoral researcher ... a visiting fellow under professor Vartkess A. Apkarian, whose ... lead by Professor Eric O. Potma. The results of ...
Breaking Biology Technology:Clintrax Global, Inc. Announces Addition to Executive Team 2Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3Seeing a molecule breathe 2
Cached News: