HOME >> BIOLOGY >> NEWS
Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover

PITTSBURGH, May 13 -- Bone marrow-derived cells give rise to fully functional liver cells, researchers at the University of Pittsburgh Medical Center have found through a series of transplant experiments, yielding the first report that such stem cells provide a lineage for cells making up solid organs. Study results, published in the May 14 issue of Science, suggest that bone marrow-derived cells could eventually repair or replace injured or diseased livers, reducing the need for transplantation. At a theoretical level, the findings disrupt the scientific dogma that plastic fetal cells are needed to generate the differentiated cells of adult organs.

"This is a critical paper that bridges a gap in our understanding of how the liver repairs itself under certain physiological conditions," said Bryon Petersen, Ph.D., research associate in pathology at the University of Pittsburgh's School of Medicine and lead investigator on the study.

For more than 40 years, scientists have witnessed the appearance and proliferation of a distinctive group of cells, called oval cells, under special animal experimental conditions. Normally, healthy liver cells, or hepatocytes, regenerate an injured liver. But if hepatocyte division is suppressed experimentally and the liver is subsequently injured, oval cells appear on the scene. In this setting they proliferate, then transform into several types of functional liver cells, thus helping to repair the damaged organ. The origin of oval cells has remained controversial, although they are known to carry markers also seen on bone marrow cells.

"Our animal experiments using cross-sex bone marrow transplants clearly show that bone marrow-derived cells eventually become fully functional liver cells, quite probably through an intermediate oval cell," said Dr. Petersen. "The next step is finding the bone marrow stem cell giving rise to the oval cell or discovering the signal that the liver broadcasts t
'"/>

Contact: Lauren Ward
wardle@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
14-May-1999


Page: 1 2 3

Related biology news :

1. Bone Marrow Transplants May Be Improved Thanks To Discovery Of Mechanism Underlying Human Stem Cell Migration
2. Clinical Trials Show That Bone Marrow Transplant And Vitamin A Derivative Both Improve Survival From Neuroblastoma
3. Duke Study Shows Early Marrow Transplant Key To Bubble Boy Disease Cure
4. Bugscope Gives Internet Users Anywhere Chance To Study Insects
5. Glowing Cyanobacteria Gives Researchers New Clues To Circadian Rhythms
6. Technique Gives Researchers New Look At Genetic Activity In Living Cells
7. Suicide Response Gives Colorado State Researchers Important Clues On Preventing Bacterial Invasion In Crops Worldwide
8. Widespread Genus Of Monkeys Gives Up Genealogical Secrets To Columbia Researchers
9. Mutate Or Die: New Polymerase Gives Desperate Yeast An Option
10. Will The Loss Of Biodiversity Alter Ecosystem Functioning?
11. Livermore research in accelerator mass spectrometry highlighted at ACS meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a ... intravenous (IV) therapy, today announced receipt of its ISO 13485 Certification, ... by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early ... "This is an ...
(Date:7/20/2017)... (NYSE: DAL ) customers now can use fingerprints instead of ... Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May ... boarding process to allow eligible Delta SkyMiles Members who are enrolled in ...
(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017 After spending the past two ... with crowdsourced data collection, GeneFo now offers this platform to healthcare ... and amplifying support, adherence, and data collection vis a vis their ... mark the successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/14/2017)... Portland, Oregon (PRWEB) , ... August 14, 2017 ... ... modules that provide essential device-to-computer interconnect using USB or PCI Express, announced the ... hardware. , SYZYGY is intended to satisfy the need for a compact, low ...
(Date:8/11/2017)... ... August 11, 2017 , ... ... and, in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President ... Wave, with the established manufacturing presence and know-how of Biorigin will allow us ...
Breaking Biology Technology:
Cached News: