HOME >> BIOLOGY >> NEWS
Bone Marrow Transplants May Be Improved Thanks To Discovery Of Mechanism Underlying Human Stem Cell Migration

REHOVOT, Israel --February 5, 1999 -- In bone marrow transplantation, a patient receives a transfusion of stem cells, which migrate to the patient's bone marrow and start producing new, healthy blood. But many transplants fail because, usually, very few stemcells make their way from the blood circulation into the recipient's marrow.

In a study published in the February 5 issue of Science, a research team headed by Dr. Tsvee Lapidot of Weizmann Institute's Immunology Department has revealed key elements of the mechanism responsible for stem cell migration from circulating blood to the the bone marrow. Furthermore, the scientists managed to dramatically increase the proportion of stem cells capable of migrating to the marrow. The research was conducted in immunodeficient mice transplanted with human stem cells.

"In the future, this approach might improve the success rate of human bone marrow transplantation," Dr. Lapidot says. He conducted this research with his team members Drs. Amnon Peled, Isabelle Petit and Orit Kollet, and departmental colleagues Drs. Ofer Lider and Ronen Alon, together with Prof. Dov Zipori of the Molecular Cell Biology Department.

Bone marrow transplantation is a last-resort treatment that saves the lives of many patients with leukemia and other malignancies and blood disorders. In a transplantation, the patient's malignant or defective marrow is destroyed, and healthy stem cells are transfused intravenously into the circulation in the hope that they will find their way to the patients bones and create normal marrow. This marrow tissue daily produces hundreds of billions of blood cells, including both red blood cells, and white blood cells which protect the body from infections as part of the immune response.

No Receptor - No Migration

The Weizmann Institute scientists found that only human stem cells equipped with a certain type of receptor, called CXCR4, migrated from the circulation to the bone marrow of exper
'"/>

Contact: Julie Osler, Director of Public Affairs
JOsler@CompuServe.com
212-779-2500
American Committee for the Weizmann Institute of Science
5-Feb-1999


Page: 1 2 3

Related biology news :

1. Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover
2. Clinical Trials Show That Bone Marrow Transplant And Vitamin A Derivative Both Improve Survival From Neuroblastoma
3. Duke Study Shows Early Marrow Transplant Key To Bubble Boy Disease Cure
4. Cells From Mother Can Boost Success Of Sibling-To-Sibling Kidney Transplants
5. Weird Creatures Have Some Lessons For Organ Transplants
6. Improved nutrition could reduce malaria burden worldwide
7. Improved nutrition could prevent more than half of the worlds child deaths annually
8. Improved crop production and fewer greenhouse gases
9. Improved medical treatment of serious heart problems focus of UH-led group
10. Improved estimates of population extinction risk (Harding and McNamara)
11. Improved guidance systems for missiles will reduce collateral damage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... (PRWEB) , ... August 24, 2020 , ... ... for the treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. ... President of Drug Discovery. , Dr. Canan previously served as Executive Director of ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a biopharmaceutical cold chain ... 5000 list. The list is the most prestigious ranking of the nation’s fastest-growing private ... this year’s list, reported three-year revenue growth of 71 percent. , The Inc. ...
(Date:8/21/2020)... Calif. (PRWEB) , ... August 19, 2020 , ... ... both Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more ... of the recently published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
(Date:7/18/2020)... ... , ... After research model surgery and catheter implantation, the long journey of ... beginning of a successful study, while protecting and accessing the catheter or device post-surgery ... Surgery from Envigo in a live webinar on Wednesday, August ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
Breaking Biology Technology:
Cached News: