HOME >> BIOLOGY >> NEWS
Bone produced from skin and gum tissue

ANN ARBOR---Using engineered skin and gingiva (gum tissue) cells, researchers at the University of Michigan School of Dentistry have produced complete bones with the same hard outer coating, spongy interior and marrow core as naturally produced bone. The researchers used the method to replace large areas of missing bone in living rats, raising the prospect of simpler, less painful bone grafts in human patients.

The experiments, published in the May 20 issue of Human Gene Therapy, also had a surprising result: the engineered cells not only delivered the bone-forming proteins they were designed to secrete, but they also participated directly in bone formation.

Current bone grafting methods involve harvesting a patient's bone marrow with a long needle or surgically removing a piece of bone, typically from the hip. With the new method, which is still in developmental stages, a tiny bit of skin or gum tissue is removed, cut into even smaller pieces, and placed in a culture dish. The cultured cells are then engineered to secrete BMP-7, a protein that induces bone formation. The engineered cells are seeded onto collagen sponges, which are placed in the area where bone repair is needed.

The research team---which included Bruce Rutherford, professor; Paul Krebsbach, assistant professor; Keni Gu, research investigator; and Renny Franceschi, associate professor---tested the system on rats that had large sections of bone missing from their skulls. New bone was produced from the rats' own skin cells, and the skulls were almost fully healed within just four weeks, "which was startling to me," says Rutherford.

The new bone looks just like naturally produced bone, and the researchers plan more experiments to find out whether it functions like natural bone. They also are experimenting with using a hydrogel---a material that changes from liquid to gel under certain conditions---instead of the collagen sponges. The particular hydrogel they use acts like "rev
'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
18-May-2000


Page: 1 2

Related biology news :

1. Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
2. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Transgenic animals produced using cultured sperm
5. Genetically modified crops in India produced greater yields, reduced pesticide use, new study finds
6. Ozone produced by antibodies during bacterial killing and in inflammation
7. Hormones modify the type of proteins produced
8. Iron-binding compounds produced by marine bacteria have important implications for marine microbial ecology
9. Neurons produced during adulthood react to stimuli
10. Researchers at Virginia Tech and CropTech Corp. receive patent for lysosomal enzymes produced in plants
11. Human Bone Disorder Reproduced In Mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... ... In its June 22 online post, business and technology news platform Superb ... founder and director of stem cell biotechnology company Asymmetrex . Superb Crew decided ... July 5 it would begin offering free tissue stem cell counting at ...
(Date:6/11/2020)... ... June 08, 2020 , ... Cryo-Cell International’s announcement comes on ... workers in the medical field. The face masks will be distributed nationwide to ... every day to provide healthcare to pregnant women. The delivery of masks is ...
(Date:6/2/2020)... ... June 02, 2020 , ... ... developer and solutions provider, today reported that the implementation of browser-based, enterprise ... by 100%, resulting in greater efficiency for global biotechnology company, bioMérieux. , ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a leading ... despite many obstacles created as a result of COVID-19. As a provider at ... medical practices and medical manufacturers by expanding access to device offerings, technology services, ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading ... Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with its ... A Safe Space™ enabled business will provide a health performance index system that scores ...
(Date:6/28/2020)... ... June 26, 2020 , ... The ... providers, today announced its strong opposition to the recently introduced bicameral Facial ... blanket ban on most federal use of nearly all biometric and related image ...
Breaking Biology Technology:
Cached News: