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Bone produced from skin and gum tissue

ANN ARBOR---Using engineered skin and gingiva (gum tissue) cells, researchers at the University of Michigan School of Dentistry have produced complete bones with the same hard outer coating, spongy interior and marrow core as naturally produced bone. The researchers used the method to replace large areas of missing bone in living rats, raising the prospect of simpler, less painful bone grafts in human patients.

The experiments, published in the May 20 issue of Human Gene Therapy, also had a surprising result: the engineered cells not only delivered the bone-forming proteins they were designed to secrete, but they also participated directly in bone formation.

Current bone grafting methods involve harvesting a patient's bone marrow with a long needle or surgically removing a piece of bone, typically from the hip. With the new method, which is still in developmental stages, a tiny bit of skin or gum tissue is removed, cut into even smaller pieces, and placed in a culture dish. The cultured cells are then engineered to secrete BMP-7, a protein that induces bone formation. The engineered cells are seeded onto collagen sponges, which are placed in the area where bone repair is needed.

The research team---which included Bruce Rutherford, professor; Paul Krebsbach, assistant professor; Keni Gu, research investigator; and Renny Franceschi, associate professor---tested the system on rats that had large sections of bone missing from their skulls. New bone was produced from the rats' own skin cells, and the skulls were almost fully healed within just four weeks, "which was startling to me," says Rutherford.

The new bone looks just like naturally produced bone, and the researchers plan more experiments to find out whether it functions like natural bone. They also are experimenting with using a hydrogel---a material that changes from liquid to gel under certain conditions---instead of the collagen sponges. The particular hydrogel they use acts like "rev
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Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
18-May-2000


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