HOME >> BIOLOGY >> NEWS
Bone produced from skin and gum tissue

ANN ARBOR---Using engineered skin and gingiva (gum tissue) cells, researchers at the University of Michigan School of Dentistry have produced complete bones with the same hard outer coating, spongy interior and marrow core as naturally produced bone. The researchers used the method to replace large areas of missing bone in living rats, raising the prospect of simpler, less painful bone grafts in human patients.

The experiments, published in the May 20 issue of Human Gene Therapy, also had a surprising result: the engineered cells not only delivered the bone-forming proteins they were designed to secrete, but they also participated directly in bone formation.

Current bone grafting methods involve harvesting a patient's bone marrow with a long needle or surgically removing a piece of bone, typically from the hip. With the new method, which is still in developmental stages, a tiny bit of skin or gum tissue is removed, cut into even smaller pieces, and placed in a culture dish. The cultured cells are then engineered to secrete BMP-7, a protein that induces bone formation. The engineered cells are seeded onto collagen sponges, which are placed in the area where bone repair is needed.

The research team---which included Bruce Rutherford, professor; Paul Krebsbach, assistant professor; Keni Gu, research investigator; and Renny Franceschi, associate professor---tested the system on rats that had large sections of bone missing from their skulls. New bone was produced from the rats' own skin cells, and the skulls were almost fully healed within just four weeks, "which was startling to me," says Rutherford.

The new bone looks just like naturally produced bone, and the researchers plan more experiments to find out whether it functions like natural bone. They also are experimenting with using a hydrogel---a material that changes from liquid to gel under certain conditions---instead of the collagen sponges. The particular hydrogel they use acts like "rev
'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
18-May-2000


Page: 1 2

Related biology news :

1. Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
2. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
3. Findings of novel nanoproperties in selenium produced by bacteria open new area of exploration
4. Transgenic animals produced using cultured sperm
5. Genetically modified crops in India produced greater yields, reduced pesticide use, new study finds
6. Ozone produced by antibodies during bacterial killing and in inflammation
7. Hormones modify the type of proteins produced
8. Iron-binding compounds produced by marine bacteria have important implications for marine microbial ecology
9. Neurons produced during adulthood react to stimuli
10. Researchers at Virginia Tech and CropTech Corp. receive patent for lysosomal enzymes produced in plants
11. Human Bone Disorder Reproduced In Mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: