HOME >> BIOLOGY >> NEWS
Boston chemist wins national award for research with enzymes, antibiotics

Christopher T. Walsh of Boston will be honored March 25 by the world's largest scientific society for his broad-ranging insights into how the enzymes of organisms drive chemical reactions, including how the antibiotic of last resort, vancomycin, can be defeated by bacterial enzymes. He will receive the 2003 Alfred Bader Award in Bioorganic Chemistry from the American Chemical Society at its national meeting in New Orleans.

In more than 35 years of research Walsh has studied a variety of enzymes, a class of proteins in humans and other organisms that orchestrate the breakdown of food, the assembly of hormones, the coagulation of blood, and the processing of neurological signals and many other functions.

"We're interested in what enzymes actually do, how they do it, what goes wrong and whether we can fix it," said Walsh, a biological chemist and professor at Harvard Medical School. About one-third of human diseases start with some malfunction in one of the body's thousands of enzymes.

Most recently his research team has focused on antibiotics, drugs that fight bacterial infections by selectively blocking bacterial enzymes while leaving human ones alone. For example, vancomycin kills bacteria by inhibiting their enzymes' ability to stitch together their cell walls.

In the early 1990s Walsh and his group discovered and characterized how some bacteria were able to evolve resistance to vancomycin's action -- by changing the shape of their strands of cell wall. Their fundamental insights have helped drug companies design new variants of vancomycin, some of which are now in human trials.

Walsh, who originally planned to go to medical school after college, was an undergraduate researcher in the laboratory of Konrad Bloch when he won the Nobel Prize in Physiology or Medicine in 1964 for his cholesterol research. "I'm sure that had something to do with my deciding I liked research better," Walsh said.

One year later he received h
'"/>

Contact: Allison Byrum
a_byrum@acs.org
202-872-4400
American Chemical Society
4-Mar-2003


Page: 1 2

Related biology news :

1. Springtime blooms seen earlier now than in the past, say Boston University biologists
2. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer
3. NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia
4. The American Society for Biochemistry and Molecular Biology meets in Boston
5. Boston chemist wins national award for protein research
6. Tufts civil engineer predicts Bostons rising sea levels could cause billions of dollars in damage
7. Childrens Hospital Boston researchers regenerate zebrafish heart muscle
8. Microorganisms are cleaning up Boston Harbor, UMass study finds
9. Highlights of American Chemical Societys national meeting in Boston
10. Childrens Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
11. Study by Boston College chemistry team shows critical role of water in protein function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/17/2016)... -- AIC announces that it has just released a new white paper authored by Zettar ... high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can be ...
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, ... developing therapeutics focused on the gut microbiome, today ... of 25,000,000 shares of its common stock and ... stock at a price to the public of ... to Synthetic Biologics from the offering, excluding the ...
(Date:11/14/2016)... Nov. 14, 2016  xG Technology, Inc. ("xG" or ... critical wireless communications for use in challenging operating environments, ... 30, 2016. Management will hold a conference call to ... p.m. Eastern Time (details below). Key Recent ... $16 million binding agreement to acquire Vislink Communication Systems. ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... UK (PRWEB) , ... December 08, 2016 , ... ... precision light to control cells — optogenetics — is key to exciting advances ... of the art, spatially patterned light projected via free-space optics stimulates small, transparent ...
(Date:12/8/2016)... England , December 8, 2016 ... has expanded its customisable SureSeq™ NGS panel range with the ... allowing fast and cost-effective study of variants in familial hypercholesterolemia ... number variation (CNV) detection on a single small panel and ... hotspot content. This includes all exons for LDLR , ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... commercial launch of flexible packaging for their exceptionally efficient human mesenchymal stem/stromal ... extends RoosterBio’s portfolio of bioprocess media products engineered to radically streamline culture ...
(Date:12/8/2016)...  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the ... and commercializing products to treat rare diseases where ... the long-term follow-up data from its Phase 2 ... Defense Regulator (IDR), in the treatment of oral ... undergoing chemoradiation therapy (CRT).  The additional 12-month safety ...
Breaking Biology Technology:
Cached News: