HOME >> BIOLOGY >> NEWS
Boston chemist wins national award for research with enzymes, antibiotics

Christopher T. Walsh of Boston will be honored March 25 by the world's largest scientific society for his broad-ranging insights into how the enzymes of organisms drive chemical reactions, including how the antibiotic of last resort, vancomycin, can be defeated by bacterial enzymes. He will receive the 2003 Alfred Bader Award in Bioorganic Chemistry from the American Chemical Society at its national meeting in New Orleans.

In more than 35 years of research Walsh has studied a variety of enzymes, a class of proteins in humans and other organisms that orchestrate the breakdown of food, the assembly of hormones, the coagulation of blood, and the processing of neurological signals and many other functions.

"We're interested in what enzymes actually do, how they do it, what goes wrong and whether we can fix it," said Walsh, a biological chemist and professor at Harvard Medical School. About one-third of human diseases start with some malfunction in one of the body's thousands of enzymes.

Most recently his research team has focused on antibiotics, drugs that fight bacterial infections by selectively blocking bacterial enzymes while leaving human ones alone. For example, vancomycin kills bacteria by inhibiting their enzymes' ability to stitch together their cell walls.

In the early 1990s Walsh and his group discovered and characterized how some bacteria were able to evolve resistance to vancomycin's action -- by changing the shape of their strands of cell wall. Their fundamental insights have helped drug companies design new variants of vancomycin, some of which are now in human trials.

Walsh, who originally planned to go to medical school after college, was an undergraduate researcher in the laboratory of Konrad Bloch when he won the Nobel Prize in Physiology or Medicine in 1964 for his cholesterol research. "I'm sure that had something to do with my deciding I liked research better," Walsh said.

One year later he received h
'"/>

Contact: Allison Byrum
a_byrum@acs.org
202-872-4400
American Chemical Society
4-Mar-2003


Page: 1 2

Related biology news :

1. Springtime blooms seen earlier now than in the past, say Boston University biologists
2. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer
3. NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia
4. The American Society for Biochemistry and Molecular Biology meets in Boston
5. Boston chemist wins national award for protein research
6. Tufts civil engineer predicts Bostons rising sea levels could cause billions of dollars in damage
7. Childrens Hospital Boston researchers regenerate zebrafish heart muscle
8. Microorganisms are cleaning up Boston Harbor, UMass study finds
9. Highlights of American Chemical Societys national meeting in Boston
10. Childrens Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
11. Study by Boston College chemistry team shows critical role of water in protein function

Post Your Comments:
(Date:10/18/2014)... a sample of patients with undiagnosed, suspected genetic conditions, ... with a higher molecular diagnostic yield than traditional molecular ... JAMA . The study is being released to coincide ... , Exome sequencing, which sequences the protein­coding region of ... material present in a cell or organism), has been ...
(Date:10/17/2014)... in German . ... day in order to reproduce? And why are there two ... the latest issue of the research journal Molecular Human ... Steven Ramm from Bielefeld University Bielefeld has compiled this special ... for a female to copulate with several males in quick ...
(Date:10/17/2014)... German . ... When treating overdoses, doctors are often limited to supportive therapy ... is a combination of drugs involved. So what can be ... grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute of ... to this question. "The task was to develop an agent ...
Breaking Biology News(10 mins):Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Sperm wars 2Emergency aid for overdoses 2Emergency aid for overdoses 3
(Date:10/20/2014)... 20, 2014 Asterias Biotherapeutics, Inc. (NYSE ... signed a Notice of Grant Award (NGA) with ... October 1, 2014.  The NGA provides for the ... release of additional grant funds pursuant to the ... clinical development of Asterias, product, AST-OPC1. The grant ...
(Date:10/20/2014)... OncLive® is pleased ... at Thomas Jefferson University has joined its Strategic ... Alliance Partnership program, the Sidney Kimmel Cancer Center ... awareness of the Center’s cutting-edge research programs, comprehensive ... and other health care professionals from the Sidney ...
(Date:10/19/2014)... , Oct. 19, 2014 NextCODE Health, which enables ... genome in real time, today announced the launch of its ... Exchange , at the American Society of Human Genetics (ASHG) ... learn more, sign up and apply for free beta access, ... features and benefits can be viewed here . ...
(Date:10/19/2014)... 19, 2014 The Asian Orthopedic braces and ... Asia with analysis and forecast of revenue. The Orthopedic braces ... to around $416.5 million by 2018, at a developing CAGR ... TOC of the Asian Orthopedic braces and support systems market, ... also provides a glimpse of the segmentation of orthopedic braces ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
Cached News: