HOME >> BIOLOGY >> NEWS
Boston chemist wins national award for research with enzymes, antibiotics

Christopher T. Walsh of Boston will be honored March 25 by the world's largest scientific society for his broad-ranging insights into how the enzymes of organisms drive chemical reactions, including how the antibiotic of last resort, vancomycin, can be defeated by bacterial enzymes. He will receive the 2003 Alfred Bader Award in Bioorganic Chemistry from the American Chemical Society at its national meeting in New Orleans.

In more than 35 years of research Walsh has studied a variety of enzymes, a class of proteins in humans and other organisms that orchestrate the breakdown of food, the assembly of hormones, the coagulation of blood, and the processing of neurological signals and many other functions.

"We're interested in what enzymes actually do, how they do it, what goes wrong and whether we can fix it," said Walsh, a biological chemist and professor at Harvard Medical School. About one-third of human diseases start with some malfunction in one of the body's thousands of enzymes.

Most recently his research team has focused on antibiotics, drugs that fight bacterial infections by selectively blocking bacterial enzymes while leaving human ones alone. For example, vancomycin kills bacteria by inhibiting their enzymes' ability to stitch together their cell walls.

In the early 1990s Walsh and his group discovered and characterized how some bacteria were able to evolve resistance to vancomycin's action -- by changing the shape of their strands of cell wall. Their fundamental insights have helped drug companies design new variants of vancomycin, some of which are now in human trials.

Walsh, who originally planned to go to medical school after college, was an undergraduate researcher in the laboratory of Konrad Bloch when he won the Nobel Prize in Physiology or Medicine in 1964 for his cholesterol research. "I'm sure that had something to do with my deciding I liked research better," Walsh said.

One year later he received h
'"/>

Contact: Allison Byrum
a_byrum@acs.org
202-872-4400
American Chemical Society
4-Mar-2003


Page: 1 2

Related biology news :

1. Springtime blooms seen earlier now than in the past, say Boston University biologists
2. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer
3. NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia
4. The American Society for Biochemistry and Molecular Biology meets in Boston
5. Boston chemist wins national award for protein research
6. Tufts civil engineer predicts Bostons rising sea levels could cause billions of dollars in damage
7. Childrens Hospital Boston researchers regenerate zebrafish heart muscle
8. Microorganisms are cleaning up Boston Harbor, UMass study finds
9. Highlights of American Chemical Societys national meeting in Boston
10. Childrens Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
11. Study by Boston College chemistry team shows critical role of water in protein function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/6/2017)... March 6, 2017 Mintigo , ... today announced Predictive Sales Coach TM , its ... sales intelligence into Salesforce. This unique AI application ... sales organizations with deep knowledge of their customers ... intelligent engagement. Predictive Sales Coach extends Mintigo,s existing ...
(Date:3/2/2017)... Summary This report provides all the information ... partnering interests and activities since 2010. Download the ... Deals and Alliance since 2010 report provides an in-depth ... world,s leading life sciences companies. On demand ... of the most up to date deal and company ...
(Date:3/2/2017)... Australia , March 2, 2017 Australian ... Ltd (ASX: CYP), has signed an agreement with ... from the Monash Biomedicine Discovery Institute and Department of ... to conduct a further preclinical study to support the ... treatment of asthma.  Asthma is a ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... , ... March 29, 2017 , ... ... comprising multiple separable adhesive layers, as issued by the U.S. Patent & Trademark ... it applies to combining electronics and health monitoring. This invention will be critical ...
(Date:3/29/2017)... Pa. , March 29, 2017 Patients ... which is why CSL Behring awards Local Empowerment for ... rare disease patient groups. These groups tackle complex legislative ... heard on Capitol Hill and in statehouses across the ... the community-based grant was awarded to New England Hemophilia ...
(Date:3/29/2017)... and HILDEN, Germany , March 29, 2017 ... PRIME STANDARD: QIA) today announced the U.S. launch of its ... which was cleared by the U.S. Food and Drug Administration as a qualitative ... genomic DNA extracted from EDTA whole blood.* ... The ipsogen JAK2 assay is processed on QIAGEN,s Rotor-Gene ® ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - Last year,s petition to ... not the only efforts active to generate awareness on the importance ... pharmaceutical drugs in the healthcare market place. ... Earlier this month Health Advance ... distributor of pharmaceutical and nutritional products, announced its endeavors on this ...
Breaking Biology Technology:
Cached News: