HOME >> BIOLOGY >> NEWS
Brain cells seen recycling rapidly to speed communications

The tiny spheres inside brain cells that ferry chemical messengers into the synapse make their rounds much more expeditiously than once assumed, National Institute of Mental Health (NIMH) - funded researchers have discovered. They used a dye to track the behavior of such synaptic vesicles in real time, in rat brain cells. Rather than fusing completely with the cell membrane and disgorging their dye contents all at once, brain vesicles more often remained intact, secreting only part of the tracer cargo in each of several repeated, fleeting contacts with the membrane, report Richard Tsien, D.Phil., Stanford University, and colleagues Alex Aravanis and Jason Pyle, in the June 5, 2003 Nature. Dubbed "kiss-and-run" recycling, this allows for more efficient communication between brain cells, suggest the researchers.

Brain cells communicate in a process that begins with an electrical signal and ends with a neurotransmitter binding to a receptor on the receiving neuron. It lasts less than a thousandth of a second, and is repeated billions of times daily in each of the human brain's 100 billion neurons. Much of the action is happening inside the secreting cell. There, electrical impulses propel vesicles into the cell wall to spray the neurotransmitter into the synapse. Likened to soap bubbles merging, or bubbles bursting at the surface of boiling water, this process of membrane fusion (*RealPlayer format) may hold clues about what goes wrong in disorders of thinking, learning and memory, including schizophrenia and other mental illnesses thought to involve disturbances in neuronal communication.

Neurons must recycle a finite number of vesicles. In "classical" membrane fusion, the vesicle totally collapses and mixes with the cell membrane, requiring a complex and time-consuming retrieval and recycling process. Yet, Tsien and colleagues point out that this process was discovered in huge neurons, such as those in squid giant synapses, with tens o
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
11-Jun-2003


Page: 1 2 3

Related biology news :

1. Brain has center for detecting sound motion
2. Brains reward circuitry revealed in procrastinating primates
3. Brain serotonin enzyme finding might explain psychiatric disorders
4. Brain development and puberty may be key factors in learning disorders
5. Organization for Human Brain Mapping 2004 Annual Meeting
6. Brain disease research, particle physics meet in the middle (ware)
7. Brain control
8. Brain cells become more discriminating when they work together
9. Brain signal predicts working memory prowess
10. Brain areas identified that decode emotions of others
11. Brain Centre gives Wales a world lead

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/19/2018)... ROCHELLE, Va. (PRWEB) , ... December 19, 2018 , ... ... former Scientific Reviewer and Compliance Officer at the FDA Center for Devices and Radiological ... with NDA Partners as an Expert Consultant since 2015, and she has more than ...
(Date:12/18/2018)... ... December 18, 2018 , ... The nation’s leader in ... marketing. The technology has been effective at reducing patient acquisition costs by over ... with clients nationwide on patient acquisition marketing programs. Traditional marketing for stem cell ...
(Date:12/14/2018)... (PRWEB) , ... December 14, 2018 , ... ... patent number 9,703,929 entitled “Method and System for Microbiome-Derived Diagnostics and Therapeutics” by ... date of October 21, 2014. The patent is an invention by uBiome collaborators ...
Breaking Biology News(10 mins):
(Date:1/4/2019)... N.C. (PRWEB) , ... January 04, 2019 , ... ... is pleased to welcome Ted Hoffman to the firm. Ted will be joining ... of experience working in and providing consulting services to the pharmaceutical industry. At ...
(Date:12/20/2018)... ... December 20, 2018 , ... New Year’s brings reflection and desire to ... in the European Union (EU) on the horizon, Jim Kasic, president and CEO of ... to the EU Medical Device Regulation (MDR), digital health, and big data are just ...
(Date:12/18/2018)... ... December 18, 2018 , ... USDM Life Sciences, the ... sciences industry, unveiled a completely redesigned website at http://www.usdm.com . The site ... for their valued clients and business partners. , The website has a ...
(Date:12/13/2018)... (PRWEB) , ... December 12, 2018 , ... ... other life science software solutions, announces the Limfinity® ML (Machine Learning) addition for ... trained machine learning models within Limfinity® solutions. In the module, trained models make ...
Breaking Biology Technology:
Cached News: