HOME >> BIOLOGY >> NEWS
Brain gene implicated in autism

Scientists funded by the National Institute of Mental Health have linked a gene that may influence human brain development with autism susceptibility. They pinpointed the candidate gene, WNT2, in a region of chromosome 7 suggested by several studies over the past few years. NIMH grantees Thomas Wassink, M.D., University of Iowa, and Joseph Piven, M.D., University of North Carolina, and colleagues, report on their findings in the American Journal of Medical Genetics , available online May 17, 2001.

Rare mutations in WNT2 may "significantly increase susceptibility to autism," say the researchers, while a common variant may contribute to the disorder to a lesser degree. "While the evidence implicating this gene is good, it's not overwhelming, and must be replicated by other groups," cautioned Wassink.

Affecting 1 in 500 to 1 in 2500 Americans, autism begins in early childhood and impairs thinking, feeling, language and the ability to relate to others. Evidence suggests that the disorder is at least 90 percent heritable, stemming from complex interactions among 3 to 15, or more, genes.

The WNT2 gene attracted the investigators' attention because of its suspect location on chromosome 7 (7q31-33); three recent genome scans had pointed to the region as likely harboring an autism gene. It is a member of a family of 16 WNT genes, a number of which are known to influence brain development. Mice bred without genes essential to the functioning of WNT genes show diminished social interaction, similar to people with autism. Also, WNT2 is located next to a broken chromosome in an individual with autism, heightening suspicion of its involvement in the disorder.

Among 135 individuals with autism screened, the researchers identified two families in which mutated variants of WNT2 were found in just one parent and in affected, but not in well, siblings. Both mutations were in coding regions of the gene. No mutated variants of WNT2 were found in 1
'"/>

Contact: Jules Asher
jasher@nih.gov
301-443-4536
NIH/National Institute of Mental Health
16-May-2001


Page: 1 2 3

Related biology news :

1. Brain has center for detecting sound motion
2. Brains reward circuitry revealed in procrastinating primates
3. Brain serotonin enzyme finding might explain psychiatric disorders
4. Brain development and puberty may be key factors in learning disorders
5. Organization for Human Brain Mapping 2004 Annual Meeting
6. Brain disease research, particle physics meet in the middle (ware)
7. Brain control
8. Brain cells become more discriminating when they work together
9. Brain signal predicts working memory prowess
10. Brain areas identified that decode emotions of others
11. Brain Centre gives Wales a world lead

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a biopharmaceutical cold ... Inc. 5000 list. The list is the most prestigious ranking of the nation’s fastest-growing ... for this year’s list, reported three-year revenue growth of 71 percent. , The ...
(Date:8/21/2020)... (PRWEB) , ... August 18, 2020 , ... ... to cell therapy, today announced that the U.S. Food and Drug Administration (FDA) ... Sentien’s lead asset, SBI-101, for the treatment of severe COVID-19. Approval of this ...
(Date:8/21/2020)... , ... August 19, 2020 , ... ... premier conference and expo uniting life science, data science, informatics and IT leaders ... , “In this period of uncertainty and change, Bio-IT takes the leadership role ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/22/2020)... ... , ... Join experts from Reed Tech , Gary Saner, Sr. Manager, ... hour live webinar on Thursday, August 13, 2020 at 11am EDT (4pm ... devices. Specifically, for medical devices, the NMPA has departments dealing with medical device registration ...
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
(Date:7/7/2020)... (PRWEB) , ... July 06, 2020 , ... ... Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, ... 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples of ...
Breaking Biology Technology:
Cached News: