HOME >> BIOLOGY >> NEWS
Brain tumors and mouse models: New insight into the development of gliomas

In the latest issue of Genes & Development, a team led by Dr. Eric Holland at the Memorial Sloan-Kettering Cancer Centre in New York reports on the development of new mouse models of brain tumors.

Gliomas are the most common form of primary brain tumors, with approximately 30,000 people in the USA newly diagnosed each year. Murine models offer a route to understand how different types and severities of gliomas arise, and an experimental system in which to test potential therapies.

Gliomas are brain tumors that have the characteristics of glial cells. Glial cells are specialised cells whose normal job is to maintain the function and interactions of neurons. Gliomas can show characteristics of either or both types of glial cells, astrocytes and oligodendrocytes. Gliomas are graded according to their severity: Grade 1 are the least serious, while Grade 4 malignant gliomas are the most serious these patients have an average survival time of 1 year from the date of diagnosis.

Previous research has shown that genetic mutations in two different cell signaling pathways can contribute to the formation of gliomas. The first group of mutations disrupt the differentiation process by which an undifferentiated progenitor cell develops into a specific type of glial cell. Such cell signaling pathways are affected by molecules called growth factors, such as platelet derived growth factor (PDGF). The second set of mutations disrupts the cell cycle arrest pathway, which regulates glial cell proliferation.

Based on these findings, Dr. Holland and colleagues used genetic tools to express PDGF in different brain cells to investigate what underlies the different characteristics of gliomas. Two mouse models were generated. One strain of mice expressed excess growth factor in undifferentiated cells, while the second second strain of mice expressed PDGF in differentiated astrocytes. Both strains of mice developed mostly low grade gliomas.

D
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
31-Jul-2001


Page: 1 2

Related biology news :

1. Brain has center for detecting sound motion
2. Brains reward circuitry revealed in procrastinating primates
3. Brain serotonin enzyme finding might explain psychiatric disorders
4. Brain development and puberty may be key factors in learning disorders
5. Organization for Human Brain Mapping 2004 Annual Meeting
6. Brain disease research, particle physics meet in the middle (ware)
7. Brain control
8. Brain cells become more discriminating when they work together
9. Brain signal predicts working memory prowess
10. Brain areas identified that decode emotions of others
11. Brain Centre gives Wales a world lead

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... ... their findings on what they believe could be a new and helpful biomarker ... new research. Click here to read it now. , Biomarkers are ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
Breaking Biology Technology:
Cached News: