Brain tumors and mouse models: New insight into the development of gliomas

In the latest issue of Genes & Development, a team led by Dr. Eric Holland at the Memorial Sloan-Kettering Cancer Centre in New York reports on the development of new mouse models of brain tumors.

Gliomas are the most common form of primary brain tumors, with approximately 30,000 people in the USA newly diagnosed each year. Murine models offer a route to understand how different types and severities of gliomas arise, and an experimental system in which to test potential therapies.

Gliomas are brain tumors that have the characteristics of glial cells. Glial cells are specialised cells whose normal job is to maintain the function and interactions of neurons. Gliomas can show characteristics of either or both types of glial cells, astrocytes and oligodendrocytes. Gliomas are graded according to their severity: Grade 1 are the least serious, while Grade 4 malignant gliomas are the most serious these patients have an average survival time of 1 year from the date of diagnosis.

Previous research has shown that genetic mutations in two different cell signaling pathways can contribute to the formation of gliomas. The first group of mutations disrupt the differentiation process by which an undifferentiated progenitor cell develops into a specific type of glial cell. Such cell signaling pathways are affected by molecules called growth factors, such as platelet derived growth factor (PDGF). The second set of mutations disrupts the cell cycle arrest pathway, which regulates glial cell proliferation.

Based on these findings, Dr. Holland and colleagues used genetic tools to express PDGF in different brain cells to investigate what underlies the different characteristics of gliomas. Two mouse models were generated. One strain of mice expressed excess growth factor in undifferentiated cells, while the second second strain of mice expressed PDGF in differentiated astrocytes. Both strains of mice developed mostly low grade gliomas.


Contact: Nora Poppito
Cold Spring Harbor Laboratory

Page: 1 2

Related biology news :

1. Brain has center for detecting sound motion
2. Brains reward circuitry revealed in procrastinating primates
3. Brain serotonin enzyme finding might explain psychiatric disorders
4. Brain development and puberty may be key factors in learning disorders
5. Organization for Human Brain Mapping 2004 Annual Meeting
6. Brain disease research, particle physics meet in the middle (ware)
7. Brain control
8. Brain cells become more discriminating when they work together
9. Brain signal predicts working memory prowess
10. Brain areas identified that decode emotions of others
11. Brain Centre gives Wales a world lead

Post Your Comments:

(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. ... human interface solutions, today announced expansion of its ... ™ touch controller and display driver integration ... of smartphones. These new TDDI products add to ... (HD resolution), TD4302 (WQHD resolution), and TD4322 (FHD ...
(Date:11/12/2015)... Mass. , Nov. 12, 2015  Arxspan ... Institute of MIT and Harvard for use of ... discovery information management tools. The partnership will support ... both biological and chemical research information internally and ... will be used for managing the Institute,s electronic ...
(Date:11/11/2015)... 11, 2015   MedNet Solutions , an innovative SaaS-based ... research, is pleased to announce that it will be a ... event, to be held November 17-19 in ... live demonstrations of iMedNet , MedNet,s easy-to-use, ... iMedNet has been able to deliver time and cost ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association (USGA) ... USGA Green Section Award. Presented annually since 1961, the USGA Green Section Award recognizes ... with turfgrass. , Clarke, of Iselin, N.J., is an extension specialist of ...
(Date:11/24/2015)... Florida (PRWEB) , ... November 24, 2015 , ... ... biggest event of the year and one of the premier annual events for ... and ran from 8–11 November 2015, where ISPE hosted the largest number of ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model Aeronautics ... (SIG), MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View (FPV) ... Many AMA members have embraced this type of racing and several new model aviation ...
(Date:11/24/2015)... , Nov. 24, 2015  Twist Bioscience, ... that Emily Leproust, Ph.D., Twist Bioscience chief executive ... Healthcare Conference on December 1, 2015 at 3:10 ... in New York City. --> ... www.twistbioscience.com . Twist Bioscience is on Twitter. Sign ...
Breaking Biology Technology:
Cached News: