Branching out: New insight into vessel branching during development

An international collaboration of scientists, led by Dr. David Shima (Cancer Research UK London Research Institute), has discovered that different forms of the vascular endothelial growth factor (VEGF) protein regulate vessel branching during mammalian embryogenesis.

As embryonic tissues form and grow, the existing vasculature branches out to provide additional oxygen to proliferating cells, and lays the foundation for the intricate vascular network that will support postnatal organ function. As published in the October 15th issue of Genes & Development, Dr. Shima and colleagues now lend valuable insight into the molecular cues that orchestrate this process.

VEGF was previously identified as a potent inducer of angiogenesis in normal physiological contexts (ie., development and wound healing), as well as in the numerous pathological contexts that entail the formation of new vasculature (ie., tumor angiogenesis). There are several different versions of the VEGF protein called isoforms -- which are generated via alternative RNA splicing from the VEGF gene. The various VEGF isoforms differ in their capacity to bind to the polysaccharide heparin, and thereby in their ability to localize to the extracellular matrix or cell surface.

To investigate the physiological roles of the VEGF isoforms, Dr. Shima and colleagues generated various strains of transgenic mice: One strain solely expressed a soluble (non-heparin-binding) VEGF isoform; another strain solely expressed a heparin-binding isoform. The researchers found that the mice that only expressed soluble VEGF displayed a marked decrease in vessel branching and had abnormally wide microvessels, while the mice that only expressed the heparin-binding VEGF isoform suffered the opposite phenotype: excessive vessel branching and abnormally thin microvasculature. The scientists went on to show that the graded concentration of both soluble and heparin-binding VEGF isoforms is necessary for normal embryon

Contact: Heather Cosel
Cold Spring Harbor Laboratory

Page: 1 2

Related biology news :

1. Brown research reveals key insight into memory-making
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Heart gene yields insights into evolution, disease risk
5. A genetic disorder yields insight into genes and cognition
6. You are what you eat: New insight into autophagy
7. Method to visualize gene activity may provide insight into normal development & genome function
8. Two-month study of life in mid-Atlantic yields trove of species, new insights & questions
9. New survey reveals insights into unique relationship between mothers and pediatricians
10. Study yields insights into precancerous condition
11. Comparing primate genomes offers insight into human evolution

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: