HOME >> BIOLOGY >> NEWS
Breaking new ground in germ cell guidance

Many types of cells are able to make their way through the body propelled by molecular motors and guided by pathfinding mechanisms. One of the great migratory phenomena in development is the journey undertaken by primordial germ cells in the Drosophila embryo. These cells form externally to the embryo at its posterior pole, are carried within by a process of invagination and navigate unerringly through the body to contribute to the formation of the gonad, acquiring the characteristics of more mature germ cells en route. The puzzle of how these cells find their way through the developing body has challenged biologists for years, but is now beginning to yield to their painstaking efforts toward identifying the underlying mechanisms that guide these travelers on their way.

Kazuko Hanyu-Nakamura and colleagues in the RIKEN Center for Developmental Biology Laboratory for Germline Development (Akira Nakamura, Team Leader; Kobe, Japan) have fit a new piece into this jigsaw with findings recently published in the online edition of Development , describing an intriguing new model of germ cell migration involving a pair of guidance molecules, Wunen and Wunen2, and their discrete activities in germ and somatic cells.

The study began with a screen for mutant flies, which uncovered a phenotype in which the flies' primordial germ cells, called "pole cells," showed defects during their migration: the pole cells died in large numbers at a stage when they would normally begin to associate with the gonadal mesoderm. The genetic deficiency responsible for the defect was identified as a maternal effect mutation, meaning that its function (or loss of function) relies entirely on transmission by the mother fly. A closer analysis of the failing pole cells indicated that they began their development and migration normally, and that their deaths did not display a significant increase in the molecular activity most commonly associated with programmed cell death activation of
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
RIKEN Center for Developmental Biology
9-Sep-2004


Page: 1 2 3

Related biology news :

1. Breaking the rules on artifical blood
2. Breaking the silence: Discovery could lead to new treatments for cancer, sickle-cell anemia
3. Breaking into the brain
4. Ground-Breaking DNA Research Leads SFU Grad To The Top
5. Underground carbon dioxide storage reduces emissions
6. Mysterious beach closures may be linked to contaminated groundwater, study finds
7. Tufts University groundbreaking research on caterpillar locomotion
8. Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
9. NCAR aircraft, ground instruments to track carbon dioxide uptake
10. Too good eyes for living below ground
11. Using soils as filters to prevent crypto from moving to the groundwater

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: