Breaking new ground in germ cell guidance

Many types of cells are able to make their way through the body propelled by molecular motors and guided by pathfinding mechanisms. One of the great migratory phenomena in development is the journey undertaken by primordial germ cells in the Drosophila embryo. These cells form externally to the embryo at its posterior pole, are carried within by a process of invagination and navigate unerringly through the body to contribute to the formation of the gonad, acquiring the characteristics of more mature germ cells en route. The puzzle of how these cells find their way through the developing body has challenged biologists for years, but is now beginning to yield to their painstaking efforts toward identifying the underlying mechanisms that guide these travelers on their way.

Kazuko Hanyu-Nakamura and colleagues in the RIKEN Center for Developmental Biology Laboratory for Germline Development (Akira Nakamura, Team Leader; Kobe, Japan) have fit a new piece into this jigsaw with findings recently published in the online edition of Development , describing an intriguing new model of germ cell migration involving a pair of guidance molecules, Wunen and Wunen2, and their discrete activities in germ and somatic cells.

The study began with a screen for mutant flies, which uncovered a phenotype in which the flies' primordial germ cells, called "pole cells," showed defects during their migration: the pole cells died in large numbers at a stage when they would normally begin to associate with the gonadal mesoderm. The genetic deficiency responsible for the defect was identified as a maternal effect mutation, meaning that its function (or loss of function) relies entirely on transmission by the mother fly. A closer analysis of the failing pole cells indicated that they began their development and migration normally, and that their deaths did not display a significant increase in the molecular activity most commonly associated with programmed cell death activation of

Contact: Doug Sipp
RIKEN Center for Developmental Biology

Page: 1 2 3

Related biology news :

1. Breaking the rules on artifical blood
2. Breaking the silence: Discovery could lead to new treatments for cancer, sickle-cell anemia
3. Breaking into the brain
4. Ground-Breaking DNA Research Leads SFU Grad To The Top
5. Underground carbon dioxide storage reduces emissions
6. Mysterious beach closures may be linked to contaminated groundwater, study finds
7. Tufts University groundbreaking research on caterpillar locomotion
8. Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
9. NCAR aircraft, ground instruments to track carbon dioxide uptake
10. Too good eyes for living below ground
11. Using soils as filters to prevent crypto from moving to the groundwater

Post Your Comments:

(Date:8/23/2017)... public,s help is being enlisted in what,s thought to be the biggest ... human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date ... project's goal is to help advance scientific knowledge of the role of ... The ...
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... compared the implantation and pregnancy rates in frozen and fresh in vitro ... of progesterone and maternal age to IVF success. , After comparing the results ...
(Date:10/10/2017)... ... 10, 2017 , ... Dr. Bob Harman, founder and CEO of VetStem ... The event entitled “Stem Cells and Their Regenerative Powers,” was held ... Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments ... consulting, Nanoscience Analytical offers a broad range of contract analysis services for ...
Breaking Biology Technology:
Cached News: