HOME >> BIOLOGY >> NEWS
Breakthrough in understanding of hereditary disease of lymphatic vessels

(Helsinki, August 22nd) -- A study from the Ludwig Institute for Cancer Research (LICR) Affiliate Center at the University of Helsinki in Finland has shed light on the development of lymphatic vasculature and valves, and may help to develop better treatments for lymphedema. The disease, which results from damaged or absent lymphatic vessels, may be inherited or may be a side-effect of the surgical removal of tumors. Lymphatic vessels normally remove fluid and proteins escaping from blood capillaries into surrounding tissues, and lymphedema is characterized by the disabling swelling of legs, and sometimes arms, that results when the lymphatic vessels are unable to clear the lymph from the tissues. The current study, which was published today in Nature Medicine, has uncovered a fundamental mechanism of the formation of lymphatic vessels.

The LICR team, together with collaborators from the UK, Japan, USA and Austria, analyzed a hereditary form of lymphedema, known as Lymphedema Distichiasis (LD), which is caused by mutations in a gene called FOXC2. The team found that the lymphatic vessels of LD patients are abnormally shaped and covered with smooth muscle cells that are usually present only on blood vessels and on larger, collecting lymphatic vessels. In addition, mutations in Foxc2 led to a lack of lymphatic valves, which prevent the reflux of lymph. This is the first study that describes a gene critical for the formation of lymphatic valves, and regulation of the interaction between lymphatic endothelial cells and vascular smooth muscle cells.

According to Professor Kari Alitalo, the senior author of the study, the insights gleaned into FOXC2 function may be applicable in the development of therapies for several disorders that affect lymphatic vessel formation. "We are currently working on approaches to stimulate the proper formation of lymphatic vessels in people who suffer from lymphedema. However, FOXC2 is produced in endothelial cells of both
'"/>

Contact: Sarah L. White, Ph.D.
swhite@licr.org
1-212-450-1543
Ludwig Institute for Cancer Research
22-Aug-2004


Page: 1 2

Related biology news :

1. Breakthrough Clemson research appears in Science
2. Breakthroughs in acoustic tracking shine new light on the lives of fish
3. Advancing Biotechnology Breakthroughs
4. Breakthroughs lead to better understanding in prevention of transfusion-transmitted infection
5. Breakthrough in fight against infection misery
6. Breakthrough in profiling of yeast genome
7. Breakthrough in creating bio-artificial organs at Hebrew University-Hadassah Dental School
8. Breakthrough in genomic technology: Identifying the biologically relevant parts of the human genome
9. Breakthrough On Microbial Disease Published In Science
10. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
11. Researchers Announce Breakthrough In Transgenic Animal Technology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/14/2016)... 2016 http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ... --> DERMALOG, le leader de ... lecteurs d,empreintes digitales pour l,enregistrement des réfugiés en ... pour produire des cartes d,identité aux réfugiés. DERMALOG ...
(Date:3/11/2016)... India , March 11, 2016 ... a new market research report "Image Recognition Market by ... Application (Marketing and Advertising), by Deployment Type (On-Premises and ... Forecast To 2022", published by MarketsandMarkets, the global market ... 2015 to USD 29.98 Billion by 2020, at a ...
(Date:3/10/2016)... BLUE BELL, Pa. , March 10, 2016   ... U.S. Customs and Border Protection (CBP) is testing ... in San Diego to help identify ... United States . The test, designed to help determine ... outdoor, pedestrian environment, began in February and will run until ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... 2016 Regen BioPharma, ... RGBPP) announced today initiation of a preclinical development ... based cancer immunotherapeutic product leveraging its NR2F6 immunological ... a generation of cord blood derived killer cells ...  The product in development will be a "universal ...
(Date:5/18/2016)... May 18, 2016 The Biotech industry ... not mean that there are no opportunities ahead. Today, ActiveWallSt.com ... (NASDAQ: THLD ), Seattle Genetics Inc. (NASDAQ: ... and Ophthotech Corp. (NASDAQ: OPHT ). Sign up ... http://www.activewallst.com/ Threshold Pharmaceuticals Inc.,s ...
(Date:5/18/2016)... ... , ... Ryan Benton was diagnosed with Duchenne Muscular Dystrophy (DMD) at the ... twenties. DMD is a relatively common progressive genetic disorder, which causes aggressive deterioration of ... critical. He met with the founder of the Stem Cell Institute in ...
(Date:5/17/2016)... Denmark (PRWEB) , ... May 17, 2016 , ... ... Women Deliver Global Conference that they will collaborate to bring a feeding cup ... Washington School of Dentistry, and the Craniofacial Center at Seattle Children’s Hospital, thereby ...
Breaking Biology Technology:
Cached News: