HOME >> BIOLOGY >> NEWS
Breakthrough in understanding of hereditary disease of lymphatic vessels

(Helsinki, August 22nd) -- A study from the Ludwig Institute for Cancer Research (LICR) Affiliate Center at the University of Helsinki in Finland has shed light on the development of lymphatic vasculature and valves, and may help to develop better treatments for lymphedema. The disease, which results from damaged or absent lymphatic vessels, may be inherited or may be a side-effect of the surgical removal of tumors. Lymphatic vessels normally remove fluid and proteins escaping from blood capillaries into surrounding tissues, and lymphedema is characterized by the disabling swelling of legs, and sometimes arms, that results when the lymphatic vessels are unable to clear the lymph from the tissues. The current study, which was published today in Nature Medicine, has uncovered a fundamental mechanism of the formation of lymphatic vessels.

The LICR team, together with collaborators from the UK, Japan, USA and Austria, analyzed a hereditary form of lymphedema, known as Lymphedema Distichiasis (LD), which is caused by mutations in a gene called FOXC2. The team found that the lymphatic vessels of LD patients are abnormally shaped and covered with smooth muscle cells that are usually present only on blood vessels and on larger, collecting lymphatic vessels. In addition, mutations in Foxc2 led to a lack of lymphatic valves, which prevent the reflux of lymph. This is the first study that describes a gene critical for the formation of lymphatic valves, and regulation of the interaction between lymphatic endothelial cells and vascular smooth muscle cells.

According to Professor Kari Alitalo, the senior author of the study, the insights gleaned into FOXC2 function may be applicable in the development of therapies for several disorders that affect lymphatic vessel formation. "We are currently working on approaches to stimulate the proper formation of lymphatic vessels in people who suffer from lymphedema. However, FOXC2 is produced in endothelial cells of both
'"/>

Contact: Sarah L. White, Ph.D.
swhite@licr.org
1-212-450-1543
Ludwig Institute for Cancer Research
22-Aug-2004


Page: 1 2

Related biology news :

1. Breakthrough Clemson research appears in Science
2. Breakthroughs in acoustic tracking shine new light on the lives of fish
3. Advancing Biotechnology Breakthroughs
4. Breakthroughs lead to better understanding in prevention of transfusion-transmitted infection
5. Breakthrough in fight against infection misery
6. Breakthrough in profiling of yeast genome
7. Breakthrough in creating bio-artificial organs at Hebrew University-Hadassah Dental School
8. Breakthrough in genomic technology: Identifying the biologically relevant parts of the human genome
9. Breakthrough On Microbial Disease Published In Science
10. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
11. Researchers Announce Breakthrough In Transgenic Animal Technology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... NEW YORK , April 5, 2017 ... security, is announcing that the server component of the ... is known for providing the end-to-end security architecture that ... customers. HYPR has already secured over 15 ... system makers including manufacturers of connected home product suites ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 ... ... announces publication of a United States multicenter, prospective clinical study that demonstrates ... point-of-care diagnostic test capable of identifying clinically significant acute bacterial and viral ...
(Date:10/11/2017)... ... October 11, 2017 , ... At ... Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist ... has been selected for membership in ARCS Alumni Hall of Fame . ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... it will be hosting a Webinar titled, “Pathology is going digital. Is your ... on digital pathology adoption best practices and how Proscia improves lab economics and ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
Breaking Biology Technology:
Cached News: