HOME >> BIOLOGY >> NEWS
Breast cancer gene repairs damaged DNA

Structural studies of the protein produced by the BRCA2 gene, which is implicated in the development of hereditary breast and ovarian cancers, reveal that the protein is intimately involved in repairing damaged DNA.

DNA-repair proteins perform a vital function and protect against potentially catastrophic events such as cancer-causing mutations or chromosome rearrangements, which are hallmarks of tumor cells.

Howard Hughes Medical Institute investigator Nikola P. Pavletich and his colleagues at Memorial Sloan-Kettering Cancer Center used x-ray crystallography to obtain "molecular snapshots" of the BRCA2 protein. The images produced by Pavletich's team show that BRCA2 is capable of binding to DNA, a conclusion that is supported by the group's biochemical experiments. The research was published in the September 13, 2002, issue of the journal Science.

The scientists were investigating the role of BRCA2 in homologous recombination, which is one of the ways that cells repair broken chromosomes. In this type of DNA repair, broken chromosomes are fixed by using the information from a sister chromosome as a template and "splint" to guide repair. This type of DNA repair is accurate and is the optimal mode of repair in dividing cells. Prior to the studies by Pavletich and his colleagues, BRCA2 was believed to play only an indirect regulatory role in DNA repair.

"BRCA2 had been previously implicated in the control of homologous recombination, although its precise role in this process was unknown," said HHMI investigator Stephen J. Elledge, who is at Baylor College of Medicine. "The significance of the structural studies of BRCA2 by Pavletich's group is that they provide evidence for a direct and unexpected biochemical role for BRCA2 in the enzymology of homologous recombination itself. It was an
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
12-Sep-2002


Page: 1 2 3

Related biology news :

1. Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
2. Breastfeeding decreases infant mortality
3. Breast cancer study suggests role for tissue in carcinogenesis
4. Breast self examination increases womens concerns but has no effect on mortality
5. Breast cancer follow-ups no longer guess-work thanks to new physics research
6. Final media advisory for the 4th European Breast Cancer Conference (EBCC-4)
7. The 4th European Breast Cancer Conference (EBCC4)
8. Breast cancer susceptibility genes play role in DNA repair
9. Breast cancer can be reversed in laboratory mice, scientists report
10. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
11. Breast fluid a better option for detecting cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Breast cancer gene repairs damaged DNA

(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... market, reports on the recent success of the Wocket™ smart wallet at ... Wocket smart wallet was named as one of the "11 Hot Products ... Best Products Launched At CES So Far" by Newseveryday.com and "The top ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) ... Wearable Technologies Market and Applications, Opportunities, Industry Analysis, ... 2014-2020" report to their offering. , ... can be worn on the user,s body and ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)...   GenoSpace , a precision medicine software company that has ... use of genomic, imaging and other biomedical data in research ... Munson , CEO of Aspera, an IBM Company, to its ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to welcome ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
Cached News: