Breast cancer gene repairs damaged DNA

Structural studies of the protein produced by the BRCA2 gene, which is implicated in the development of hereditary breast and ovarian cancers, reveal that the protein is intimately involved in repairing damaged DNA.

DNA-repair proteins perform a vital function and protect against potentially catastrophic events such as cancer-causing mutations or chromosome rearrangements, which are hallmarks of tumor cells.

Howard Hughes Medical Institute investigator Nikola P. Pavletich and his colleagues at Memorial Sloan-Kettering Cancer Center used x-ray crystallography to obtain "molecular snapshots" of the BRCA2 protein. The images produced by Pavletich's team show that BRCA2 is capable of binding to DNA, a conclusion that is supported by the group's biochemical experiments. The research was published in the September 13, 2002, issue of the journal Science.

The scientists were investigating the role of BRCA2 in homologous recombination, which is one of the ways that cells repair broken chromosomes. In this type of DNA repair, broken chromosomes are fixed by using the information from a sister chromosome as a template and "splint" to guide repair. This type of DNA repair is accurate and is the optimal mode of repair in dividing cells. Prior to the studies by Pavletich and his colleagues, BRCA2 was believed to play only an indirect regulatory role in DNA repair.

"BRCA2 had been previously implicated in the control of homologous recombination, although its precise role in this process was unknown," said HHMI investigator Stephen J. Elledge, who is at Baylor College of Medicine. "The significance of the structural studies of BRCA2 by Pavletich's group is that they provide evidence for a direct and unexpected biochemical role for BRCA2 in the enzymology of homologous recombination itself. It was an

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
2. Breastfeeding decreases infant mortality
3. Breast cancer study suggests role for tissue in carcinogenesis
4. Breast self examination increases womens concerns but has no effect on mortality
5. Breast cancer follow-ups no longer guess-work thanks to new physics research
6. Final media advisory for the 4th European Breast Cancer Conference (EBCC-4)
7. The 4th European Breast Cancer Conference (EBCC4)
8. Breast cancer susceptibility genes play role in DNA repair
9. Breast cancer can be reversed in laboratory mice, scientists report
10. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
11. Breast fluid a better option for detecting cancer

Post Your Comments:

(Date:10/6/2015)... SALT LAKE CITY , Oct. 6, 2015 /PRNewswire/ ... solutions company, announced today that it has signed a ... electronic monitoring services across the full range of sentences ... Track Group,s President of the Americas. "This contract with ... Eastern region of the US and advances our position ...
(Date:10/5/2015)... October 5, 2015 http://soundview.co ... for NXT-ID, Inc. (NASDAQ: NXTD ), a biometric ... --> http://soundview.co ) releases the ... NXTD ), a biometric authentication company focused on ... Technology Group ( http://soundview.co ) releases the ...
(Date:10/1/2015)... YORK , Oct. 1, 2015  Biometrics ... and analysing human body characteristics, such as fingerprints, ... authentication purposes. Adoption of biometrics technology has been ... over the last five years. In addition to ... that is fingerprint recognition, other means of biometric ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... 2015 El 8 de octubre, la Honorable ... el congreso con su declaración acerca del reconocimiento de ... Week (IPAW), que se celebrará del 11 al 17 ... Plasma Protein Therapeutics Association (PPTA) y sus compañías ... la concienciación mundial acerca de la donación de plasma ...
(Date:10/12/2015)...  Patara Pharma, a clinical-stage biotechnology company developing ... conditions, today announced the closing of a $26 ... the close of its sale of preferred stock, ... Agreement with Silicon Valley Bank whereby the Company ... use the funds from the financing to evaluate ...
(Date:10/12/2015)... , October 12, 2015 DorlandsOnline.com ... print version for enriched online experience --> ... alternative to print version for enriched online experience ... multi media alternative to print version for enriched ... provider of scientific, technical and medical information products and ...
(Date:10/12/2015)... ... October 12, 2015 , ... ... Dr. Srini Srinivasan, has joined the firm as a Premier Expert consultant. ... enable them to bring extraordinary value to the company's clients. Premier Experts ...
Breaking Biology Technology:
Cached News: