Breast fluid a better option for detecting cancer

RICHLAND, Wash. - A new method of extracting and analyzing fluid from a woman's breast may provide a more accurate, less expensive and noninvasive way to determine a patient's risk for breast cancer or to diagnose the disease in its early stages.

In a paper published in the July 3 issue of Breast Cancer Research and Treatment, Battelle scientists at the Department of Energy's Pacific Northwest National Laboratory and researchers at University of California, Los Angeles report they have discovered six times more proteins than previously identified in this fluid, called nipple aspirate fluid, or NAF. The presence of such proteins suggests that NAF could be a resource for biomarkers, or biological indicators, of breast cancer, which is expected to claim the lives of approximately 40,000 American women this year.

"We believe this fluid could be the best alternative for discovering biomarkers for early-stage breast cancer," said Rick Zangar, a Battelle principal investigator at PNNL. "With further analysis, we could detect up to 10 times more proteins in NAF. The more proteins we identify, the better chance there is to find one that is linked to breast cancer."

Proteins can serve as biomarkers of disease. When cancerous cells begin to develop, they create their own proteins that, if detected in NAF, could indicate the presence or risk of breast cancer. Current methods for screening include breast self-exams and mammograms, which are physical exams compared with the molecular approach at PNNL.

NAF is continuously secreted and reabsorbed in breasts of women who aren't pregnant or lactating. It is generated from cells lining the ducts that form a network throughout the breast, the same network that provides milk in a lactating woman. These ductal cells are the source of 70 to 80 percent of breast cancer.

"NAF offers a unique window through which we can monitor the processes occurring inside the breast ductal system," Zangar said

Contact: Staci Maloof
DOE/Pacific Northwest National Laboratory

Page: 1 2 3

Related biology news :

1. Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
2. Breastfeeding decreases infant mortality
3. Breast cancer study suggests role for tissue in carcinogenesis
4. Breast self examination increases womens concerns but has no effect on mortality
5. Breast cancer follow-ups no longer guess-work thanks to new physics research
6. Final media advisory for the 4th European Breast Cancer Conference (EBCC-4)
7. The 4th European Breast Cancer Conference (EBCC4)
8. Breast cancer susceptibility genes play role in DNA repair
9. Breast cancer can be reversed in laboratory mice, scientists report
10. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
11. Breastfeeding may compensate for harmful effects of smoking during pregnancy

Post Your Comments:

(Date:2/1/2020)... (PRWEB) , ... February 01, 2020 , ... Liver cancer, ... world and about 700,000 die from the disease. HCC is the 5th most common ... place among all countries when it comes to incidence of HCC, while China has ...
(Date:1/28/2020)... (PRWEB) , ... January 28, 2020 , ... ... life sciences companies and government agencies, announced that the firm has established a ... country. Tunnell’s Cambridge office will be in the Cambridge Innovation Center (CIC), at ...
(Date:1/24/2020)... ... January 24, 2020 , ... The ... Colorado’s capital resources to support early-stage bioscience companies in the state. ... struggled to find the funding they need to innovate and grow. This ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Ovation Travel ... Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , All of ... the following statistics:, Average airfare price paid Domestically, ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... exclusive distributor to food and beverage manufactures within North America. Both Lifecycle and ... This agreement will allow each company to pool their collective resources and provide ...
(Date:1/28/2020)... Pa. (PRWEB) , ... January 28, 2020 , ... ... of Better Salivary Assay Kits . The new Salivary Total Human ... research. “By measuring total immunoglobulin G in saliva, researchers can extend the accuracy ...
(Date:1/27/2020)... (PRWEB) , ... January 27, 2020 , ... ... announced it has secured financing from strategic investors led by Halma plc ... from existing investors Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A ...
Breaking Biology Technology:
Cached News: