Brookhaven scientists create new ways to tag and track molecules

UPTON, NY–Scientists at the U.S. Department of Energy's Brookhaven National Laboratory are developing a wide array of metallic "tags" to label proteins and other molecules. These tags will expand the toolbox scientists use to decode molecular structures, diagnose and treat diseases, and trace the movement of antibodies and drugs within cells.

"These labels help us tag and see microscopic cell components, and solve the structure of molecules to see how the molecules work," says James Hainfeld, a Brookhaven biophysicist. Hainfeld is guest-editor of the September 1999 issue of the Journal of Structural Biology, which features the most current work in this field, known as heavy metal cluster labeling. The range of applications is limited only by the scientists' ability to custom-design the appropriate tag for the task.

For example, metal particles are used in home pregnancy test kits, producing the readable pink color when proteins associated with pregnancy are present. Similarly, scientists use the metal particles to track the movement of drugs within cells. A California company has used gold-labeled molecules to follow the delivery of an antifungal drug into its target cells. "By using gold labels, they were able to demonstrate the efficacy of the treatment. Otherwise you can't really see what's going on."

In another study, a metallic tag helped identify one of the key infection-initiating proteins on the surface of the Hepatitis B virus. "If you can understand where these proteins are and how they work, you can understand the virus better," Hainfeld says. That knowledge might eventually lead to ways to defeat the virus.

Tags can also be used to label the products of bioengineering and to detect the presense of antibodies, potentially increasing the sensitivity of some diagnostic techniques. Some tags might even serve as "magic bullets" to deliver cell-killing radiation doses directly to cancer cells withou

Contact: Karen McNulty
DOE/Brookhaven National Laboratory

Page: 1 2

Related biology news :

1. Brookhaven lab biophysicist F. William Studier wins R&D 100 award
2. Workshop for new synchrotron light source at Brookhaven
3. Brookhaven Lab expects $30 million to support life sciences
4. Brookhaven Lab develops ThraxVac to clean up anthrax
5. Brookhaven Lab & Battelle collaborate on research that may lead to novel anti-microbial drugs
6. Rice, Brookhaven physicists decode initial stage of cell fusion
7. Brookhaven Lab scientist wins Environmental Mutagen Society Award
8. Brookhaven Spotlights: News from the National Synchrotron Light Source
9. Enzyme studies at Brookhaven Lab may lead to new antiviral agents
10. Brookhaven scientists determine key Lyme disease protein structure
11. New Brookhaven Lab study shows how ritalin works

Post Your Comments:

(Date:8/23/2020)... WOODLANDS, Texas (PRWEB) , ... August 21, 2020 ... ... from Rigaku Corporation has been published and is now available on ... single crystal X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic ...
(Date:8/21/2020)... ... August 19, 2020 , ... The 19th Annual ... science, data science, informatics and IT leaders goes VIRTUAL and announces its updated ... and change, Bio-IT takes the leadership role of keeping our life science community ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... that are ideal for public health agencies of all sizes. With a focus ... helping at-risk individuals find appropriate health care, Mosio helps public health departments automate ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... , ... August 29, 2020 , ... ... Animal Nutrition manufacturing capability in Wuxi, China. The new plant operation will provide ... standards and advanced technology. , “This facility will improve the flexibility of ...
(Date:8/15/2020)... ... 13, 2020 , ... Inc. magazine today revealed that Skysis ... of the nation’s fastest-growing private companies. The list represents a unique look at ... businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, and many other well-known names gained ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... validation engineering firm, is making available for free its new white paper ... concurrent transport simulation testing into today’s biologics licensing application (BLA). In response, ...
(Date:8/7/2020)... THE WOODLANDS, Texas (PRWEB) , ... August 06, ... ... gene therapy and DNA vaccine industries, announces it has closed on the purchase ... Deison Technology Park in Conroe, TX and includes over 21 acres in the ...
Breaking Biology Technology:
Cached News: