HOME >> BIOLOGY >> NEWS
Brookhaven scientists determine key Lyme disease protein structure

structure.

John Dunn, a member of the research team from Brookhaven, explains that the structure of OspC is predominantly helical, and very different from OspA, which is flat. Also, a region on the surface of OspC has a strong negative charge. Dunn says the negatively charged region may be attracted to a positively charged site on the surface of human cells, helping the bacterium to cause infection. This feature is only found in the OspC protein derived from bacterial strains that cause human disease.

The scientists believe that a vaccine based on OspC will be more effective than the current OspA-based vaccine because the OspA protein is only present in the bacteria while they are in the cold-blooded deer ticks stomach, and not in the host. After the tick bites the warm-blooded mammalian host, the injected bacteria produce OspC in the hosts bloodstream.

When the host is vaccinated solely with OspA, antibodies to this protein can only kill the bacterium inside the tick if it ingests these antibodies with its blood-meal. If the bacterium finds its way into the host, it changes into several other forms for which the vaccine offers no protection.

In contrast, an OspC-based vaccine would enable the host to make antibodies to kill the Lyme disease bacteria within the hosts body.

Another member of the Brookhaven team, Subramanyam Swaminathan, added, In order to develop an effective OspC-based vaccine, well have to know the three-dimensional structures of at least a few variants of OspC, especially those from invasive strains. Since weve solved the structure of OspC based on two infectious strains of the Lyme disease bacterium, we now have a prototype for determining the structure of OspC from other strains.


'"/>

Contact: Diane Greenberg
greenb@bnl.gov
631-344-2347
DOE/Brookhaven National Laboratory
27-Feb-2001


Page: 1 2

Related biology news :

1. Brookhaven lab biophysicist F. William Studier wins R&D 100 award
2. Workshop for new synchrotron light source at Brookhaven
3. Brookhaven Lab expects $30 million to support life sciences
4. Brookhaven Lab develops ThraxVac to clean up anthrax
5. Brookhaven Lab & Battelle collaborate on research that may lead to novel anti-microbial drugs
6. Rice, Brookhaven physicists decode initial stage of cell fusion
7. Brookhaven Lab scientist wins Environmental Mutagen Society Award
8. Brookhaven Spotlights: News from the National Synchrotron Light Source
9. Enzyme studies at Brookhaven Lab may lead to new antiviral agents
10. New Brookhaven Lab study shows how ritalin works
11. New test for radiation damage to DNA developed at Brookhaven Lab

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... Jan. 18, 2017  In vitro diagnostic (IVD) companies ... and acquisitions (M&A), and Kalorama Information expects that trend ... have been shifting. Generally, uncertainty in reimbursement and healthcare ... U.S. has changed the acquisitions landscape. Instead of looking ... companies buying partners outside of their home country and ...
(Date:1/13/2017)... 13, 2017 Sandata Technologies, LLC, a ... homecare industry, including Electronic Visit Verification™ (EVV™), announced ... Jugs, as Senior Vice President of Product Management. ... of homecare experience to Sandata, where he will ... to align Sandata,s suite of solutions with the ...
(Date:1/12/2017)...  New research undertaken by Fit Small Business ... participants were simply asked which office technology had they not ... standard issue.  Insights on what will be key ... futurists and industry leaders including Penelope Trunk , ... Some of these findings included; ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... , February 17, 2017 ... Market by Product (Consumables, Service), Type (Safety, Efficacy, ... Development, Drug Discovery and Development, Disease-Risk) - Global ... is projected to reach USD 53.34 Billion by ... at a CAGR of 13.8% during the forecast ...
(Date:2/16/2017)... ... February 16, 2017 , ... EIT Digital has launched work to ... industry. Pilot studies are about to get under way for the framework, which is ... innovations. The concept is expected to be transferred eventually to other industries that also ...
(Date:2/16/2017)... 16, 2017  ArmaGen, Inc., a privately held ... treat severe neurological disorders, today reported preliminary evidence ... the company,s investigational therapy for the treatment of ... type I, or MPS I). The initial results ... presented today at the 13 th annual ...
(Date:2/16/2017)... 16, 2017 UCHealth ( Aurora, Colorado ... for pulmonary nodule patient management. In addition to optimizing ... spot on the lung, UCHealth looks to improve provider ... entry. Stephanie Brown, RN , Thoracic ... patients with an Excel spreadsheet, which was extremely arduous ...
Breaking Biology Technology:
Cached News: