HOME >> BIOLOGY >> NEWS
Brookhaven scientists determine key Lyme disease protein structure

structure.

John Dunn, a member of the research team from Brookhaven, explains that the structure of OspC is predominantly helical, and very different from OspA, which is flat. Also, a region on the surface of OspC has a strong negative charge. Dunn says the negatively charged region may be attracted to a positively charged site on the surface of human cells, helping the bacterium to cause infection. This feature is only found in the OspC protein derived from bacterial strains that cause human disease.

The scientists believe that a vaccine based on OspC will be more effective than the current OspA-based vaccine because the OspA protein is only present in the bacteria while they are in the cold-blooded deer ticks stomach, and not in the host. After the tick bites the warm-blooded mammalian host, the injected bacteria produce OspC in the hosts bloodstream.

When the host is vaccinated solely with OspA, antibodies to this protein can only kill the bacterium inside the tick if it ingests these antibodies with its blood-meal. If the bacterium finds its way into the host, it changes into several other forms for which the vaccine offers no protection.

In contrast, an OspC-based vaccine would enable the host to make antibodies to kill the Lyme disease bacteria within the hosts body.

Another member of the Brookhaven team, Subramanyam Swaminathan, added, In order to develop an effective OspC-based vaccine, well have to know the three-dimensional structures of at least a few variants of OspC, especially those from invasive strains. Since weve solved the structure of OspC based on two infectious strains of the Lyme disease bacterium, we now have a prototype for determining the structure of OspC from other strains.


'"/>

Contact: Diane Greenberg
greenb@bnl.gov
631-344-2347
DOE/Brookhaven National Laboratory
27-Feb-2001


Page: 1 2

Related biology news :

1. Brookhaven lab biophysicist F. William Studier wins R&D 100 award
2. Workshop for new synchrotron light source at Brookhaven
3. Brookhaven Lab expects $30 million to support life sciences
4. Brookhaven Lab develops ThraxVac to clean up anthrax
5. Brookhaven Lab & Battelle collaborate on research that may lead to novel anti-microbial drugs
6. Rice, Brookhaven physicists decode initial stage of cell fusion
7. Brookhaven Lab scientist wins Environmental Mutagen Society Award
8. Brookhaven Spotlights: News from the National Synchrotron Light Source
9. Enzyme studies at Brookhaven Lab may lead to new antiviral agents
10. New Brookhaven Lab study shows how ritalin works
11. New test for radiation damage to DNA developed at Brookhaven Lab

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/6/2017)... Colo. , Jan. 5, 2017  SomaLogic ... the "Digital Life Alliance" established by iCarbonX, the ... 2015 to build a "Global Digital Health Ecosystem ... on a combination of individual,s biological, behavioral and ... the agreement between the companies, SomaLogic will provide ...
(Date:1/3/2017)... , Jan. 3, 2017 Onitor, provider ... introduction of Onitor Track, an innovative biometric data-driven program ... showcasing this month at the 2017 Consumer Electronics Show ... In the U.S., the World Health Organization ... than two-thirds of adults who are overweight or obese. ...
(Date:12/20/2016)... 2016   Valencell , the leading innovator ... STMicroelectronics (NYSE: STM), a global semiconductor leader serving ... today the launch of a new, highly accurate ... includes ST,s compact SensorTile turnkey multi-sensor ... sensor system. Together, SensorTile and Benchmark deliver the ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... Branford, Conn. (PRWEB) , ... January 11, 2017 ... ... life sciences company developing an innovative cellular response analysis platform to measure the ... a competitive Phase I Small Business Innovation Research (SBIR) grant from the National ...
(Date:1/11/2017)... ... ... Back pain relief technology is now available without a prescription at What A ... for WAR members. , This spinal restoration platform boasts utilization of technology that has ... from chronic back pain. , What A Relief Back Pain Centers ( ...
(Date:1/11/2017)... SAN DIEGO , Jan. 11, 2017 /PRNewswire/ ... first-in-class antibody product candidates focused on unmet medical ... Dominic Piscitelli as chief financial officer.  ... AnaptysBio,s finance strategy, as well as overseeing the ... "We are pleased to welcome Dominic to ...
(Date:1/11/2017)... ... January 11, 2017 , ... KBioBox ... agreement with Poseida Therapeutics Inc, the San Diego based specialist in gene and ... selected KBioBox in order to harness KBioBox’s powerful BioEngine Algorithms which do not ...
Breaking Biology Technology:
Cached News: