HOME >> BIOLOGY >> NEWS
Brown University research team finds keys to liver development

Researchers at Brown University have identified the primary signals that tell an embryo where and when a liver should appear and have used those signals to direct immature mouse cells to become liver cells and begin liver formation.

Understanding how to control both tissue growth and cell identity may lead to new disease-fighting methods that would rely on tissue regeneration and the ability to reprogram diseased cells into normal ones.

"This basic research won't translate into a cure tomorrow, but opens the way to think about new mechanisms of dealing with certain tissue degenerative diseases, particularly of the liver," said Ken Zaret, professor of molecular biology, cell biology and biochemistry in the Brown School of Medicine. "The liver is a critical organ and a target for viral hepatitis, alcoholism, metabolic diseases and cancer."

The experiments were conducted using undifferentiated cells, called endoderm cells, removed from the inner layer of mouse embryos. In the developing mouse, these endoderm cells have the potential to become a liver, pancreas, or other gut organs, based on the signals received.

In the June 18 issue of Science, Zaret and colleagues describe the signaling mechanisms that initiate these unspecialized embryonic cells to begin liver formation. The researchers developed the techniques to sift through tiny fragments of tissue to identify the relevant signaling factors. In doing so, they found that the growth factors FGF1 and FGF2, and to some extent FGF8, begin the liver development process by differentiating the multi-potential endoderm cells into liver cells. FGF8 also helps prompt the cells to begin growing and forming liver tissue.

"Three signals are being conveyed to make sure that the liver appears at a specific time and place," Zare
'"/>

Contact: Scott Turner
Scott_Turner@Brown.edu
401-863-1862
Brown University
18-Jun-1999


Page: 1 2

Related biology news :

1. Brown research reveals key insight into memory-making
2. Brown ecologist garners major National Science Foundation grant
3. Two enzymes key to calorie-burning, Brown research shows
4. Brown earns prestigious geography award
5. Brown and MBL create an alliance for teaching and research
6. Brown researchers use wildcards to develop better way to sequence DNA
7. Brown team looks for new ways to examine scientific data
8. Brown engineering and neuroscience group wins grant for brain study
9. Fishermen Are Killing Brown Pelicans With Kindness
10. Indiana University, EPA to study airborne PCBs
11. University of Alberta researcher looks for clues to mysterious disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:8/22/2017)... ... August 22, 2017 , ... Cutting Edge Spine , ... differentiated spinal implant technologies, announced today the appointment of Luke Maher as Director ... industry experience to directing Cutting Edge Spine’s national sales force, including 12+ years ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... Big Island of Hawaii, is pleased to announce the first Delos Wellness Signature™ ... MacArthur Sotheby’s International Realty is working together with listing agent Kelly Allen, R(S) ...
(Date:8/21/2017)... ... 21, 2017 , ... The team at Cell Signaling ... which attendees will learn about the assembly and topological architecture of mammalian SWI/SNF ... of the development and validation of new high-quality recombinant monoclonal antibodies, participants will ...
(Date:8/17/2017)... Coral Springs, FL (PRWEB) , ... August 17, ... ... today announced that the stock market news outlet had provided a research update ... the company's nasally administered TRT product. , According to Soulstring, prescription rates for ...
Breaking Biology Technology:
Cached News: