HOME >> BIOLOGY >> NEWS
Brown University research team finds keys to liver development

Researchers at Brown University have identified the primary signals that tell an embryo where and when a liver should appear and have used those signals to direct immature mouse cells to become liver cells and begin liver formation.

Understanding how to control both tissue growth and cell identity may lead to new disease-fighting methods that would rely on tissue regeneration and the ability to reprogram diseased cells into normal ones.

"This basic research won't translate into a cure tomorrow, but opens the way to think about new mechanisms of dealing with certain tissue degenerative diseases, particularly of the liver," said Ken Zaret, professor of molecular biology, cell biology and biochemistry in the Brown School of Medicine. "The liver is a critical organ and a target for viral hepatitis, alcoholism, metabolic diseases and cancer."

The experiments were conducted using undifferentiated cells, called endoderm cells, removed from the inner layer of mouse embryos. In the developing mouse, these endoderm cells have the potential to become a liver, pancreas, or other gut organs, based on the signals received.

In the June 18 issue of Science, Zaret and colleagues describe the signaling mechanisms that initiate these unspecialized embryonic cells to begin liver formation. The researchers developed the techniques to sift through tiny fragments of tissue to identify the relevant signaling factors. In doing so, they found that the growth factors FGF1 and FGF2, and to some extent FGF8, begin the liver development process by differentiating the multi-potential endoderm cells into liver cells. FGF8 also helps prompt the cells to begin growing and forming liver tissue.

"Three signals are being conveyed to make sure that the liver appears at a specific time and place," Zare
'"/>

Contact: Scott Turner
Scott_Turner@Brown.edu
401-863-1862
Brown University
18-Jun-1999


Page: 1 2

Related biology news :

1. Brown research reveals key insight into memory-making
2. Brown ecologist garners major National Science Foundation grant
3. Two enzymes key to calorie-burning, Brown research shows
4. Brown earns prestigious geography award
5. Brown and MBL create an alliance for teaching and research
6. Brown researchers use wildcards to develop better way to sequence DNA
7. Brown team looks for new ways to examine scientific data
8. Brown engineering and neuroscience group wins grant for brain study
9. Fishermen Are Killing Brown Pelicans With Kindness
10. Indiana University, EPA to study airborne PCBs
11. University of Alberta researcher looks for clues to mysterious disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brown University research team finds keys liver development

(Date:10/30/2014)... October 2014 Biological membranes are mainly composed of ... of solution ions onto lipid membranes helps clarify ... study provides a quantitative description of the equilibria ... Kotyńska and Zbigniew Figaszewski from the University of ... describing these findings, just published in EPJ ...
(Date:10/29/2014)... 2014, Beaverton, OR) New research presented at ... Conference in Houston, TX showed for the first ... infection in women using a readily available nutritional ... presented by Dr. Judith A. Smith, Pharm.D., associate ... Reproductive Sciences at The University of Texas Health ...
(Date:10/29/2014)... nanoparticles is all the rage. Thousands of scientists worldwide ... of whether titanium dioxide nanoparticles from sun creams can ... carbon nanotubes from electronic products are as hazardous for ... nanoparticles in food can get into the blood via ... research funds are flowing – and the number of ...
Breaking Biology News(10 mins):Ion adsorption matter in biology 2HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3
(Date:10/30/2014)... Oct. 30, 2014  Ardelyx, Inc. (NASDAQ: ... on cardio-renal, gastrointestinal and metabolic diseases, today announced ... results on Thursday, November 6, 2014. Following the ... live conference call and webcast at 4:30pm ET ... a business update. The live webcast ...
(Date:10/30/2014)... On October 26th at the Mid ... leading applied stem cell research scientist Neil Riordan, ... talks on New Techniques for Enhancing Stem Cell ... Cells. , Dr. Riordan focused on historical medical ... AlphaGEMS that include: wound healing; inflammation and pain ...
(Date:10/30/2014)... James Sherley says he has been working towards ... technology since his days as a principal investigator at the ... 1990’s. Sherley founded the ASCTC as a new Boston ... intellectual property developed in Sherley’s research over the years since ... Technology (MIT), and more recently as a senior scientist at ...
(Date:10/30/2014)... Avure Technologies celebrates a year of success and the one-year ... of high volume High Pressure Processing (HPP) systems. , “We’re ... PackExpo this year, which is where we first announced the ... CEO at Avure. “Sales of the new Avure machine are ... challenges of market demand for higher throughput. We sold our ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
Cached News: