HOME >> BIOLOGY >> NEWS
Brown University research team finds keys to liver development

Researchers at Brown University have identified the primary signals that tell an embryo where and when a liver should appear and have used those signals to direct immature mouse cells to become liver cells and begin liver formation.

Understanding how to control both tissue growth and cell identity may lead to new disease-fighting methods that would rely on tissue regeneration and the ability to reprogram diseased cells into normal ones.

"This basic research won't translate into a cure tomorrow, but opens the way to think about new mechanisms of dealing with certain tissue degenerative diseases, particularly of the liver," said Ken Zaret, professor of molecular biology, cell biology and biochemistry in the Brown School of Medicine. "The liver is a critical organ and a target for viral hepatitis, alcoholism, metabolic diseases and cancer."

The experiments were conducted using undifferentiated cells, called endoderm cells, removed from the inner layer of mouse embryos. In the developing mouse, these endoderm cells have the potential to become a liver, pancreas, or other gut organs, based on the signals received.

In the June 18 issue of Science, Zaret and colleagues describe the signaling mechanisms that initiate these unspecialized embryonic cells to begin liver formation. The researchers developed the techniques to sift through tiny fragments of tissue to identify the relevant signaling factors. In doing so, they found that the growth factors FGF1 and FGF2, and to some extent FGF8, begin the liver development process by differentiating the multi-potential endoderm cells into liver cells. FGF8 also helps prompt the cells to begin growing and forming liver tissue.

"Three signals are being conveyed to make sure that the liver appears at a specific time and place," Zare
'"/>

Contact: Scott Turner
Scott_Turner@Brown.edu
401-863-1862
Brown University
18-Jun-1999


Page: 1 2

Related biology news :

1. Brown research reveals key insight into memory-making
2. Brown ecologist garners major National Science Foundation grant
3. Two enzymes key to calorie-burning, Brown research shows
4. Brown earns prestigious geography award
5. Brown and MBL create an alliance for teaching and research
6. Brown researchers use wildcards to develop better way to sequence DNA
7. Brown team looks for new ways to examine scientific data
8. Brown engineering and neuroscience group wins grant for brain study
9. Fishermen Are Killing Brown Pelicans With Kindness
10. Indiana University, EPA to study airborne PCBs
11. University of Alberta researcher looks for clues to mysterious disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brown University research team finds keys liver development

(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces its biometric payment ... campaign on CNBC television starting March 30 th . ... airing in New York markets. ... "We are excited about our new ad campaign following the ...
(Date:3/19/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet ... on Washington DC,s Fox 5 News ... Next Great Thing", host Laura Evans calls the ... really big breakthrough in mobile payment.,  Award-winning ...
(Date:3/16/2015)... HANOVER, Germany , March 16, 2015 /PRNewswire/ ... DERMALOG Identification Systems GmbH will present groundbreaking innovations ... Hanover, Germany . ... DERMALOG,s latest biometric innovation is well at ... the next generation e-gate made in ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
(Date:3/31/2015)... FRANCISCO , March 31, 2015  Sonoa Health, ... Australia , has developed a world-first consumer health ... records, medication prescriptions, wearable devices and more. ... Stewart as its CEO, who brings to the ... corporate advisory, which has included working closely with the ...
(Date:3/31/2015)... DALLAS and NEW YORK ... Inc. (NASDAQ: PTBI ), a biopharmaceutical company ... products, announced today that its Korean marketing partner, ... received marketing approval in Korea from the country,s ... the Korea Testing & Research Institute (KTR) for ...
(Date:3/31/2015)... 31, 2015 Diasome Pharmaceuticals, Inc. ( ... Inc., that a United States patent has recently been ... , Entitled “Lipid Construct for Delivery of ... matter claims related to the use of Diasome’s proprietary ... injected insulin to more effectively reach the liver’s metabolic ...
(Date:3/30/2015)... , March 30, 2015  Multiple new research abstracts ... several important health factors. From their impact on colon ... positive effect on both gut health and vascular health, ... detail our latest understanding of walnuts, inner workings. Running ... , this annual meeting attracts an international audience ...
Breaking Biology Technology:Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 2PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 3Diasome Pharmaceuticals, Inc. Announces Notice of Allowance from US PTO for Liver Targeting System for Insulin 2New Findings Support the Benefits of Eating Walnuts on Overall Health 2New Findings Support the Benefits of Eating Walnuts on Overall Health 3New Findings Support the Benefits of Eating Walnuts on Overall Health 4
Cached News: