HOME >> BIOLOGY >> NEWS
Brown research reveals key insight into memory-making

PROVIDENCE, R.I. -- How information is stored in the nervous system, a key to memory and learning, is one of the hottest topics in neuroscience today. New research conducted at Brown University and Duke University Medical Center, published in the current issue of Science, fills in important details about cellular changes that occur when experience becomes memory.

This process is called long-term potentiation or LTP. When LTP occurs in the hippocampi, two curved regions that flank the center of the brain, changes occur in synapses. These connections between neurons the major site for information exchange in the brain become stronger after repeated stimulation. This increased synaptic strength can last hours, even days, and is believed to be the cellular basis for memory.

AMPA receptors on the membrane of the information-receiving neuron, known as the postsynaptic cell, act like gates, opening in response to chemical messages from a neighboring neuron. During LTP, extra AMPA receptors appear, increasing synaptic strength. But where do these extra receptors come from?

Michael Ehlers, associate professor of neurobiology at Duke, believed that recycling endosomes, or membrane-bound compartments inside neurons, carry a reserve pool of these receptors. To test his theory, Ehlers called on Julie Kauer at Brown.

Kauer, associate professor medical science in the Department of Molecular Pharmacology, Physiology and Biotechnology, proved that Ehlers' theory was correct. By injecting mutant proteins marked with green fluorescent dye into the hippocampal neurons of rats, Kauer and her laboratory team found that AMPA receptors are indeed stored in recycling endosomes. When the neuron is stimulated, AMPA receptors leave this compartment and are rushed down the dendritic spine by three "chaperone" proteins Rab11a, Rme1, and Syn13. These additional receptors are then inserted into the plasma membrane, boosting reception of memory-making infor
'"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
23-Sep-2004


Page: 1 2

Related biology news :

1. Brown ecologist garners major National Science Foundation grant
2. Two enzymes key to calorie-burning, Brown research shows
3. Brown earns prestigious geography award
4. Brown and MBL create an alliance for teaching and research
5. Brown researchers use wildcards to develop better way to sequence DNA
6. Brown team looks for new ways to examine scientific data
7. Brown engineering and neuroscience group wins grant for brain study
8. Brown University research team finds keys to liver development
9. Fishermen Are Killing Brown Pelicans With Kindness
10. Leader in cancer treatment and prevention research honored
11. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/18/2018)... SEATTLE (PRWEB) , ... December 18, 2018 , ... ... company developing non-invasive treatments for cancers and other serious diseases, today announced the ... Voyager device is safe for treatment of rGBM. , The publication of ...
(Date:12/13/2018)... ... December 12, 2018 , ... NDA Partners Chief Executive Officer ... Expert Consultants, was recently honored by the American Association of Pharmaceutical Scientists (AAPS) ... pharmaceutical science, technology, engineering, or education and whose contributions to the pharmaceutical sciences ...
(Date:12/13/2018)... (PRWEB) , ... December 13, 2018 , ... ... just released a must-see documentary entitled “What Researchers Need to Know about ... Issues in Life Science Research series. The goal of this film is to ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... WASHINGTON (PRWEB) , ... December 05, 2018 , ... STRmix™ ... too complex to interpret – has been used to convict a Wyoming man of ... Wyoming’s State Crime Laboratory used STRmix™ to test for DNA on the couch cushions ...
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's Founder and ... as experience the height of truffle season. , Her first stop was ... Staying in the exclusive Black Truffle Lodge in the small mountain village of Pettino, ...
(Date:11/20/2018)... ... November 19, 2018 , ... The International Society ... the Chinese translation of Best Practices: Recommendations for Repositories, Fourth Edition. , The ... at advancing the science of biobanking to meet the needs of a growing ...
(Date:11/20/2018)... ... 2018 , ... Dr. Steven White and Dr. Brad Haines invite new and ... NC. This common infection, left untreated, can be destructive to oral and overall health. ... certification in laser dentistry, Drs. White and Haines are uniquely qualified to diagnose and ...
Breaking Biology Technology:
Cached News: