HOME >> BIOLOGY >> NEWS
Brown researchers use wildcards to develop better way to sequence DNA

Two Brown computer science professors are working on a method to sequence DNA that they believe will be faster and more efficient than the technique currently used by mappers of the human genome. Franco Preparata and Eliezer Upfal are attempting to make improvements to a lesser-used method known as sequencing by hybridization. In their method, they insert gaps that act as wildcards in DNA probes.

When sequencing DNA, scientists look for the arrangement of bases (amino acids represented by the letters C,T,G and A) contained in a particular strand of DNA, which is too small to be seen under a microscope.

In the decade-old hybridization method, short sequences of DNA bases six to 20 bases long are used as probes to find the bases contained in a long string of DNA. The DNA to be sequenced binds to some of the probes on a tiny glass chip called a microarray.

The target DNA binds to probes that match its sequence (T always pairs with A, and G always pairs with C). Then the DNA can be detected and read. Using the information obtained from the probes on the microarray, a computer program is then used to construct the long sequence of bases in the target DNA strand. Current techniques can construct only a few hundred bases.

What we show is that you would be able to sequence a substantially longer piece of DNA, Upfal said. Instead of a few hundred bases, you could do tens of thousands.

Based on a novel mathematical insight, Preparata and Upfal have designed a new pattern for the probes on the chip. In the new pattern, some of the DNA bases in each probe are replaced by gaps that act like wildcards. The new design extracts substantially more information about the DNA
'"/>

Contact: Janet Kerlin
janet_kerlin@brown.edu
401-863-2476
Brown University
17-Oct-2000


Page: 1 2

Related biology news :

1. Brown research reveals key insight into memory-making
2. Brown ecologist garners major National Science Foundation grant
3. Two enzymes key to calorie-burning, Brown research shows
4. Brown earns prestigious geography award
5. Brown and MBL create an alliance for teaching and research
6. Brown team looks for new ways to examine scientific data
7. Brown engineering and neuroscience group wins grant for brain study
8. Brown University research team finds keys to liver development
9. Fishermen Are Killing Brown Pelicans With Kindness
10. Belgian researchers explore revolutionary approach to angiogenesis
11. Award winning researchers reveal potential new role for Glivec

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/27/2020)... ... , ... On Thursday, February 20, 2020 at 10am EST (3pm GMT/UK), join ... Richard Castle, Global Account Manager Medical Device at PRISYM ID for an ... timing deadlines, best practices in creating and submitting product data and best practices in ...
(Date:1/23/2020)... ATLANTA (PRWEB) , ... January 23, 2020 , ... ... to manufacture lifesaving mature red blood cells from stem cells. The red ... red blood cells, under strictly controlled conditions, for transfusion therapy and replaces the ...
(Date:1/22/2020)... ... January 21, 2020 , ... Modality ... supporting global regulatory applications, and executing global clinical trial operations. Milestone highlights ... a fastest growing company, and ISO 9001:2015 certification with the scope of ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Ovation Travel Group ... Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , All of the ... following statistics:, Average airfare price paid Domestically, Internationally ...
(Date:1/27/2020)... ... January 27, 2020 , ... Cerebyte, the leader in ... computing, today announced the availability of neuroscience of transformational leadership workshops. These highly ... neuroscience of leadership and change research to become great transformational leaders. The ...
(Date:1/23/2020)... ... 2020 , ... Ideal Implant CEO and President Robert S ... North American investor forums specializing in medical advancements. New technology was presented to ... on November 21, 2019 in New York City, and the Aesthetic Technology Summit ...
(Date:1/10/2020)... ... January 09, 2020 , ... A new report ... for the vendor qualification process, a critical element of clinical trial set up ... of the vendor qualification process creates delays in initiation in 7% of clinical ...
Breaking Biology Technology:
Cached News: