HOME >> BIOLOGY >> NEWS
Building a better atlas of yeast proteins

Using high-tech robots and old-fashioned hard labor, Howard Hughes Medical Institute researchers have measured the abundance and pinpointed the cellular locations of more than 4,000 proteins in yeast.

Proteins are the workhorse molecules of the cell. They catalyze reactions, transport molecules within the cell and switch genes on and off. Measuring the abundance of and identifying the cellular locations of yeast proteins will be invaluable in helping to understand the complex biology of a relatively simple organism. Beyond that, however, the effort is emblematic of a shift in biological research, toward understanding how changes in the "proteome" -- the interacting global network of proteins in a cell -- can influence cellular "behavior."

Research teams led by HHMI investigators Erin K. O'Shea and Jonathan S. Weissman, both of the University of California at San Francisco, published two research articles describing their work in the October 16, 2003, issue of the journal Nature.

"We have now made the yeast proteome accessible in a way it simply wasn't before," said Weissman. "Now, investigators can measure the abundance of proteins and follow their location with a degree of sensitivity that was never possible for any proteome in any organism. We believe that this capability really strengthens the status of yeast as the premier organism for the systems-biology approach to a coherent, comprehensive understanding of how the cell works."

According to the researchers, determining the relative abundance of proteins in yeast will offer more insight into protein function than do studies of levels of messenger RNA (mRNA), the most widely used indicator of cellular activity. Messenger RNA molecules are the genetic templates for proteins. In constructing proteins, the mRNA template is transcribed from gene
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
15-Oct-2003


Page: 1 2 3 4 5

Related biology news :

1. Building the whole cell from pieces
2. Digital Biology Week: Building a national infrastructure for biomedical computing
3. Building the next generation of cancer researchers
4. The frontier of microelectronics: Building nano-machines, part by part
5. Building better engines through natural selection
6. Building detailed map of human DNA will take more time and resources than previously thought, says Hutch researcher
7. Household Fungus Contributes To "Sick Building Syndrome"
8. Brain Building May Depend On DNA Cutting And Pasting
9. Body Building: Tissue Engineered Organs A Heartbeat Away
10. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
11. Microbes eat their way to better concrete

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... BOSTON (PRWEB) , ... January 10, 2019 , ... When ... company Asymmetrex , was invited to contribute a chapter to the new book ... “I wanted to continue Asymmetrex’s effort to address a debilitating secret of stem cell ...
(Date:1/8/2019)... ... January 07, 2019 , ... ... is proud to welcome Thomas Kennedy as head of sales and business development ... PureWay. , Mr. Kennedy has previously worked for Johnson & Johnson Medical, Globus ...
(Date:1/7/2019)... ... 07, 2019 , ... Franz Inc. , an early ... Knowledge Graphs solutions, announced that it was recognized by Database Trends and ... and information management recognition list includes newer approaches leveraging artificial intelligence, machine learning, ...
Breaking Biology News(10 mins):
(Date:12/20/2018)... (PRWEB) , ... December 20, 2018 , ... New Year’s ... with major changes in regulations in the European Union (EU) on the horizon, Jim ... to consider. , “The transition to the EU Medical Device Regulation (MDR), digital health, ...
(Date:12/18/2018)... , ... December 18, 2018 , ... ... process optimization firm for the life sciences industry, unveiled a completely redesigned website ... creating a more user-friendly browsing experience for their valued clients and business partners. ...
(Date:12/13/2018)... ... December 12, 2018 , ... RURO, ... solutions, announces the Limfinity® ML (Machine Learning) addition for its Limfinity® 7 framework. ... within Limfinity® solutions. In the module, trained models make predictions based on user ...
(Date:12/5/2018)... ... December 05, 2018 , ... Leading authority on how to bridge the gap ... “The Referral Playbook: How to Increase Sales with Proven Networking Strategies.” ... to the Alzheimer’s Foundation of America (AFA). , Itzkowich is hosting “The Referral ...
Breaking Biology Technology:
Cached News: