HOME >> BIOLOGY >> NEWS
Building a better atlas of yeast proteins

Using high-tech robots and old-fashioned hard labor, Howard Hughes Medical Institute researchers have measured the abundance and pinpointed the cellular locations of more than 4,000 proteins in yeast.

Proteins are the workhorse molecules of the cell. They catalyze reactions, transport molecules within the cell and switch genes on and off. Measuring the abundance of and identifying the cellular locations of yeast proteins will be invaluable in helping to understand the complex biology of a relatively simple organism. Beyond that, however, the effort is emblematic of a shift in biological research, toward understanding how changes in the "proteome" -- the interacting global network of proteins in a cell -- can influence cellular "behavior."

Research teams led by HHMI investigators Erin K. O'Shea and Jonathan S. Weissman, both of the University of California at San Francisco, published two research articles describing their work in the October 16, 2003, issue of the journal Nature.

"We have now made the yeast proteome accessible in a way it simply wasn't before," said Weissman. "Now, investigators can measure the abundance of proteins and follow their location with a degree of sensitivity that was never possible for any proteome in any organism. We believe that this capability really strengthens the status of yeast as the premier organism for the systems-biology approach to a coherent, comprehensive understanding of how the cell works."

According to the researchers, determining the relative abundance of proteins in yeast will offer more insight into protein function than do studies of levels of messenger RNA (mRNA), the most widely used indicator of cellular activity. Messenger RNA molecules are the genetic templates for proteins. In constructing proteins, the mRNA template is transcribed from gene
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
15-Oct-2003


Page: 1 2 3 4 5

Related biology news :

1. Building the whole cell from pieces
2. Digital Biology Week: Building a national infrastructure for biomedical computing
3. Building the next generation of cancer researchers
4. The frontier of microelectronics: Building nano-machines, part by part
5. Building better engines through natural selection
6. Building detailed map of human DNA will take more time and resources than previously thought, says Hutch researcher
7. Household Fungus Contributes To "Sick Building Syndrome"
8. Brain Building May Depend On DNA Cutting And Pasting
9. Body Building: Tissue Engineered Organs A Heartbeat Away
10. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
11. Microbes eat their way to better concrete

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... ... November 07, 2018 , ... ... advisory firm serving the life science industry. The event was attended by 150 ... that advance biological research and drug discovery. The winners were determined by responses ...
(Date:11/6/2018)... (PRWEB) , ... November 06, 2018 , ... ... R&D, today announced that Sartorius Stedim Cellca GmbH, a subsidiary of Sartorius Stedim ... large-scale protein production, has licensed the Genedata Bioprocess ® enterprise platform to ...
(Date:11/3/2018)... ... November 01, 2018 , ... Karius , the leading infectious disease ... study human pathogens in pediatric patients. One grant of up to $50,000 will be ... test for infectious diseases. In addition to the funding, Karius will cover the cost ...
Breaking Biology News(10 mins):
(Date:11/9/2018)... SAN FRANCISCO (PRWEB) , ... November 08, 2018 ... ... addition of Dr. Pablo Valenzuela, PhD, co-Founder, Chief Executive Officer and President of ... and doctors from around the world, Dr. Valenzuela brings to uBiome expertise on ...
(Date:11/6/2018)... TAHOE, Nev. (PRWEB) , ... November 06, 2018 ... ... their native mobile app for clinical trial data collection and management. TrialKit ... iPhone users with compatible generation devices can quickly and easily sign in to ...
(Date:11/3/2018)... ... November 01, 2018 , ... Come to Princeton Nov. ... Senior Advisor, Division of Clinical Compliance Evaluation, CDER, FDA will be presenting on ... , What should clinical research industry stakeholders keep in mind when implementing and ...
(Date:10/31/2018)... , ... October 30, 2018 , ... ... continue to be a very important aspect of experimental biology. Reproducibility of cell-based ... experimental data. Despite of choosing the appropriate assay type, there are many more ...
Breaking Biology Technology:
Cached News: