HOME >> BIOLOGY >> NEWS
Busy sequencing technique saves money and time

A computer scientist at Washington University in St. Louis has developed a novel technique to extract more DNA from a single sequence reaction than is normally possible, reducing both cost and time of the sequencing process.

Michael R. Brent, Ph.D., associate professor of computer science, has applied software developed in his Washington University laboratory that sorts through the maize of genetic information and finds predicted sequences.

"Normally, you get one 600 to 700 base pair sequence in a reaction, but under certain conditions, we've figured out how to get more than one sequence out of a single sequencing reaction," said Brent. "In most cases, people would throw out a reaction with more than one sequence but we've developed software that allows us to sort out the mess and figure out the different sequences."

Writing in the April issue of Genome Research, Brent and collaborators at Baylor College of Medicine, led by Richard A. Gibbs, Ph.D., director of Baylor's Human Genome Sequencing Center, discuss related techniques in genome analysis, while noting that the recent publication of a third mammalian genome, the brown rat, suggests a new approach to genome annotation is needed. Sequencing genomes has proven to be so labor-intensive and expensive that researchers fear little headway will be made in future genome analyses. Thus, the need for automated analysis.

The researchers describe their method of predicting genes in the brown rat using Brent's TWINSCAN software, which predicts the existence of genes by looking at two genomes in parallel and homing in on statistical patterns in the individual DNA sequences of each genome. The recently completed sequencing of the brown rat genome was conducted primarily using another program called Ensembl.

Brent and his collaborators tested 444 TWINSCAN-predicted rat genes that showed significant homology, or correspondence, to known human genes implicated in disease. Ensembl and other
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
10-May-2004


Page: 1 2

Related biology news :

1. Washington University in St. Louis plays key role in sequencing moss genome
2. JGI announces community sequencing program portfolio
3. NHGRI adds 18 organisms to sequencing pipeline
4. Kangaroo hops in line for genome sequencing
5. Laboratory rat gene sequencing completed
6. Marsupial among model organisms next in line for sequencing
7. Scientists report first sequencing of environmental genome
8. JGI launches community sequencing program
9. New technology will speed genome sequencing
10. NHGRI selects sequencing centers
11. K-State scientists beetle chosen for national genome sequencing project

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/29/2020)... STATE COLLEGE, Pa. (PRWEB) , ... January 29, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, has announced a ... Shareholders in the upcoming weeks, INDIGO showed more than a twenty percent increase ...
(Date:1/28/2020)... ... 2020 , ... Blue Health Intelligence (BHI) published an article ... and limit the utilization of high-cost imaging and surgeries for musculoskeletal (MSK) injuries. ... specializes in improving care delivery for MSK conditions. In an independent study using ...
(Date:1/24/2020)... ... ... Shoreline Biome , a microbiome research company that develops tools for characterizing ... a novel new DNA isolation kit at the Miami Winter Symposium 2020 , ... is a fast and easy-to-use kit designed for the efficient and unbiased isolation of ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... ... Travel, Law Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , ... Index illustrates the following statistics:, Average airfare price ...
(Date:1/28/2020)... ... January 28, 2020 , ... Today, Salimetrics announced an ... new Salivary Total Human IgG Assay Kit exemplifies Salimetrics’ 20+ year ... researchers can extend the accuracy and ease of use of salivary bioscience into ...
(Date:1/24/2020)... RIDING, Va. (PRWEB) , ... January 24, 2020 ... ... and other innovations created by companies in biotechnology, diagnostics, therapeutics, laboratory and clinical ... lives of millions of people around the world. And as Slone Partners ...
(Date:1/22/2020)... (PRWEB) , ... January 21, 2020 , ... ... hiring of Darrell Taylor as Southern Midwest Region Industrial and Institutional (I&I) Account ... SporActiv™ product line. , Darrell brings over 30 years of sales ...
Breaking Biology Technology:
Cached News: