CYP17 gene proves important in determining bone growth, find University of Pittsburgh investigators

Men with a minor gene mutation produce more of the hormone testosterone and may have stronger, larger bones, according to Joseph Zmuda, research associate at the University of Pittsburgh Graduate School of Public Health, in a presentation delivered Sunday, Oct. 3, at the national meeting of the American Society for Bone and Mineral Research.

"We know that men with a family history of the bone-weakening disease osteoporosis are more likely to develop this disease, so it appears there are genes involved," said Mr. Zmuda. "Finding these genes may eventually lead to better ways of diagnosing and treating osteoporosis."

Mr. Zmuda's research shows that men who carry a common mutation in the cytochrome P450c17 (CYP17) gene produce more testosterone and have larger, stronger bones. CYP17 is responsible for making testosterone, a hormone that is important in developing strong bones.

The CYP17 gene naturally comes in several forms, or alleles, with an individual inheriting one allele from each parent. Two common alleles are known as 'C' and 'T.' The combination of two inherited alleles is referred to as a 'genotype.'

The University of Pittsburgh study measured hormone levels, stature and the mass and size of the hip bone in 333 Caucasian men aged 51-84 years. While age and body weight did not differ by CYP17 genotype, researchers found that blood testosterone levels were 20 percent higher in men with two 'C' alleles (C/C), compared with men who had two 'T' alleles (T/T). Men with the C/C genotype were taller and had larger bones.

"Osteoporosis is a complex disease, and it is unlikely that there is a single gene that causes this disorder in most people," said Mr. Zmuda. "But this study is a step toward our goal of understanding the genetics of osteoporosis. We intend to conduct further research to see if having the CYP17 mutation is connected with the risk of osteoporosis-related fractures in men."


Contact: Kathryn Duda
University of Pittsburgh Medical Center

Page: 1

Related biology news :

1. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
2. FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
3. Study shows that ultrasound accreditation improves the quality of ultrasound practice
4. Releasing pet fish into the wrong ocean proves a diaster
5. European Commission approves Herceptin + Taxotere as 1st-line therapy in HER2-positive breast cancer
6. Small trial shows daclizumab add-on therapy improves MS outcome
7. Combination therapy dramatically improves function after spinal cord injury in rats
8. Moderate iron deficiency affects cognitive performance - but iron supplementation improves it
9. Longer-term, moderate exercise improves immune activity
10. New approach limits damage after heart attack and improves survival, say Scripps Research scientists
11. Online calculator improves analysis of chemical data

Post Your Comments:

(Date:8/7/2020)... ... 06, 2020 , ... Nine middle school teachers from eight ... a unique professional development program that provides advanced STEM (science, technology, engineering and ... nationwide. , Created in partnership between the National Stem Cell Foundation and The ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin ... portfolio with a near term focus on Type 2 diabetes and associated comorbidities. ... across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin will lead ...
(Date:7/10/2020)... , ... July 08, 2020 , ... ... Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • ... comparability study, but what is the most effective way to complete one? Will ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
(Date:7/22/2020)... ... 2020 , ... Join experts from Reed Tech , Gary Saner, Sr. ... one hour live webinar on Thursday, August 13, 2020 at 11am EDT ... medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical device ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign , ... and prevention of high-burden diseases, and Centric Consulting, a business and technology consulting ... utilize existing data in order to identify and prioritize patients for care. , ...
Breaking Biology Technology:
Cached News: