Calcium channel involved in coronary artery relaxation

A genetically engineered mouse initially designed to explore muscle repair mechanisms instead helped University of Iowa scientists understand how a certain type of calcium channel helps coronary arteries to relax.

The study, reported in the Nov. 21 issue of Science, sheds light on the role of T-type calcium channels in coronary artery relaxation and may provide insight into causes of some types of coronary artery disease.

Calcium channels are proteins that allow calcium ions to flow into cells. This influx of calcium plays a role in many important cell functions including muscle contraction.

Previous research suggesting that T-type calcium channels may be involved in cellular events critical for muscle regeneration made this protein an interesting target for the UI team led by Kevin Campbell, Ph.D., professor and interim head of physiology and biophysics, professor of neurology in the UI Roy J. and Lucille A. Carver College of Medicine, and a Howard Hughes Medical Institute (HHMI) investigator.

However, when the researchers genetically engineered mice to lack the T-type calcium channel, the mice did not have skeletal muscle defects. Instead, the mice developed cardiomyopathy, or damaged heart muscle.

"Loss of the protein caused heart disease in the mice," Campbell said. "But T-type calcium channels are not expressed in normal adult heart muscle cells, they are expressed in the smooth muscle that surrounds the heart's blood vessels. This suggested that the problem might lie in the smooth muscle tissue."

Chien-Chang Chen, Ph.D., UI postdoctoral fellow in Campbell's lab and first author of the study, took a closer look at the coronary arteries in mice without the calcium channel. He and his colleagues found that the coronary arteries were abnormally constricted and misshapen.

Chen and Kathryn Lamping, Ph.D., UI associate professor of internal medicine and pharmacology and a member of the Iowa Cardiovascular Cente

Contact: Jennifer Brown
University of Iowa

Page: 1 2 3 4

Related biology news :

1. Calcium supplements associated with decreased risk of large bowel polyps
2. Calcium channels control coronary artery relaxation
3. Calcium signals found to guide nerve cell development
4. Calcium and Lead: should you worry?
5. Calcium absorption is not affected by a high protein diet
6. Calcium is not as readily absorbed from soy milk as from cows milk
7. Calcium not the only key to bone health in older women
8. Purdue Study: Calcium May Curb Weight Gain In Young Women
9. Trees Need Calcium Too
10. New England Journal Of Medicine Reports Calcium Supplements Help Prevent Polyp Recurrence; DMS Led Study
11. Study: Calcium Supplements Appear To Protect Against Colorectal Cancer

Post Your Comments:

(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is helping ... equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , ... for more than 10 years. Early in the COVID-19 crisis, we identified supply ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to ... a near term focus on Type 2 diabetes and associated comorbidities. , Justin ... therapeutic areas and classes. As Chief Commercial Officer, Justin will lead Better ...
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... ... that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise control device ... The study reported that the Neoasis™ device attenuated the alarm sounds from patient ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... 2020 , ... True Terpenes , the leading platform for terpene innovation, ... to research the medical potential of terpenes and the potential entourage effect , ... board is focused on expanding the recently launched line of effects-based terpenes - ...
(Date:8/7/2020)... ... 06, 2020 , ... VGXI, a highly regarded CDMO supporting ... purchase of greenfield for a new, expanded manufacturing facility. The site is located ... the initial acquisition, with an option to purchase an additional 21 acres for ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. ... can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI ... two switches in a push-pull configuration; yielding fast fall time for a capacitive ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... industry, today announced the release of its signature product called Beacon - ... (MSLs) and other field medical professionals. , Beacon helps MSLs streamline ...
Breaking Biology Technology:
Cached News: