HOME >> BIOLOGY >> NEWS
Can a plant that acts like poison ivy cure prostate cancer?

NEW BRUNSWICK/PISCATAWAY, N.J. A shrub found in Southeast Asia can give you a rash like poison ivy; but it may also stop prostate cancer.

The croton plant, long known to oriental herbalists and homeopaths as a purgative, has an oil in its seeds that shows promise for the treatment of prostate cancer the second leading cause of cancer death in men in the United States. The active ingredient in the oil is 12-O-tetradecanoylphorbol-13-acetate, a compound generally known as TPA.

The finding was reported in the March 1, 2004, issue of Cancer Research by Xi Zheng, Allan Conney and other scientists at the Susan Lehman Cullman Laboratory for Cancer Research at Rutgers, The State University of New Jersey, and the Cancer Institute of New Jersey (CINJ).

"We demonstrated that TPA could simultaneously stop the growth of new prostate cancer cells, kill existing cancer cells and ultimately shrink prostate tumors," said Conney, the William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research at Rutgers' Ernest Mario School of Pharmacy, and a member of CINJ.

In addition to studies on the effect of TPA alone, the researchers also tested TPA in combination with all-trans retinoic acid (ATRA), a vitamin A derivative previously shown to be effective in treating leukemia.

"We knew that ATRA is an effective synergist with TPA in treating leukemia cells in the laboratory, but prostate cancer is a different situation, probably involving different molecular mechanisms," Conney said.

The studies by Zheng and Conney are the first to show an impressive synergy between TPA and ATRA in inhibiting the growth of cultured prostate cancer cells and the first to assess their combined effects, and the effects of TPA alone, on human tumors grown in mice.

Scientists, intrigued by the skin-irritating property of croton see
'"/>

Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers, the State University of New Jersey
17-Mar-2004


Page: 1 2

Related biology news :

1. Pack-MULEs are toting a new look at plant evolution
2. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
3. Pollutant causes delayed flowering in plants
4. NSF awards 22 new projects for plant genome research
5. K-State, other universities to study how climate affects plant evolution
6. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
7. Pig-human transplantation not PERVerted
8. Purdue study finds antioxidant protects metal-eating plants
9. Patented process preserves transplant tissues/organs
10. New discovery may help transplants survive
11. Babies with DiGeorge syndrome saved by immune supression, thymus transplant

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... The August edition of ... now available on the company’s global website. Crystallography Times—an electronic newsletter published by ... news and crystallographic research. , The latest issue of Crystallography Times introduces ...
(Date:8/21/2020)... ... 20, 2020 , ... NDA Partners Chairman Carl Peck, ... with expertise in clinical trial planning and feasibility, regulatory inspection readiness, and clinical ... his career, Mr. Movahhed has helped design and manage oncology, neurology, cardiovascular, and ...
(Date:8/7/2020)... LOUISVILLE, Ky. (PRWEB) , ... August 06, 2020 ... ... been selected to participate in the prestigious National STEM Scholar Program, a unique ... national network building, and project support for middle school science teachers nationwide. , ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... , ... August 13, 2020 , ... ... annual Inc. 5000 list, the most prestigious ranking of the nation’s fastest-growing private ... the American economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... 2020 , ... Anomet Products has introduced new custom composite ... with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad Wire ... and cost criteria; especially where solid wire is limited. Typical configurations for implantable ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). ... Specifically, for medical devices, the NMPA has departments dealing with medical device registration (pre-market ...
Breaking Biology Technology:
Cached News: