Can female adult obesity be stopped at birth?

July 29, 2003 -- Bethesda, MD American society today wants things fixed instantly. Among the most prominent searches for the "quick fix" is weight loss. Could our own physiology rather than a purchased liquid concoction one day be the key to female obesity? Perhaps.


The body's energy homeostasis is maintained by a highly complex and integrated neurohormonal system that minimizes fluctuations in energy balance. Neurohormones are formed by neurosecretory cells and liberated by nerve impulses (e.g., norepinephrine). Their contribution towards this energy balance includes hormonal secretion sometimes in proportion to the body fat mass and the central nervous system (CNS) targets on which these hormones act.

Of the CNS targets, a complex array of hypothalamic neuropeptides constitutes the appetite regulation system. Of these neuropeptides, NPY, a 36-amino acid orexigenic peptide, is released at the nerve terminals. In the adult rat, NPY has been observed to play a key role in affecting hyperphagia (gluttony) with resultant obesity. Various hormones orchestrate the synthesis and release of this neuropeptide. For example, pancreatic insulin and leptin released by adipocytes have been reported to suppress the synthesis and release of hypothalamic NPY, thereby potentially forming a feedback system in regulating appetite, feeding behavior, and energy balance.

A previous study demonstrated that disturbances in the fetal metabolic environment of diabetic rat or an intrauterine growth-restricted (IUGR) fetus can also alter postnatal brain NPY mRNA and peptide concentrations. This, and other research, demonstrated the presence and regulation of NPY in the fetal and neonatal hypothalamus, yet the exact functional role of this peptide during the early stages of development remains to be ascertained. Accordingly, the functional relevance of a postnatal increase in hypothalamic NPY as seen in the IUGR fetus/newborn is unknown.


Contact: Donna Krupa
American Physiological Society

Page: 1 2 3 4 5

Related biology news :

1. When male fish hum, females swim in, thanks to hormones, adaptable hearing
2. Feeding cottonseed meal to female fallow deer safe at low rates
3. For a male sand goby, playing Mr. Mom is key to females heart
4. MGH study finds female mammals produce egg cells into adulthood
5. Link between alcohol consumption and muscle damage in females
6. OHSU researchers reveal relationship between weight gain and female hormones
7. Male flesh flies high-speed pursuit of females
8. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
9. Chlamydia infection prevalent among female army recruits
10. Newly mapped enzyme could yield new treatments for female sexual dysfunction
11. Four gene micronet found to regulate social behavior in female mice

Post Your Comments:

(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
(Date:3/21/2016)... , March 22, 2016 ... recognition with passcodes for superior security   ... a leading provider of secure digital communications services, today ... biometric technology and offer enterprise customers, particularly those in ... facial recognition and voice authentication within a mobile app, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and ... clinical trial team. , Using the CONSULT module, patients and physicians can schedule a ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. ... the faculty of the University of North Carolina Kenan-Flagler Business School ... entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
Breaking Biology Technology:
Cached News: