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Can female adult obesity be stopped at birth?

New Study

Researchers have speculated that high levels of intracerebroventricular NPY during the critical stages of postnatal development will have an immediate positive effect on body weight gain, reflecting increased milk intake and a permanent influence on adult appetite, feeding behavior, and body weight gain pattern. To test this hypothesis, they undertook the present investigation and examined the effect of intracerebroventricular NPY on newborn body weight gain and adult food intake and body weight gain pattern.

The authors of "Postnatal Intracerebroventricular Exposure to Neuropeptide Y Causes Weight Loss in Female Adult Rats" are Amit Varma, Jing He, Lisa Weissfeld, and Sherin U. Devaskar, all from the University of Pittsburgh Schools of Medicine and Public Health, Pittsburgh, PA; and with the cooperation of the Department of Pediatrics, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA. Their findings appear in the June 2003 edition of the American Journal of Physiology--Regulatory, Integrative and Comparative Physiology.

Methodology

Gestationally timed pregnant Sprague-Dawley rats were allowed to deliver, and the number of pups in a litter was culled or expanded to 10 to minimize the effect of litter size on postnatal nutrition and body weight. The litters (n = 400 pups from 40 litters) of pups were arbitrarily divided into two major groups, of which one of the groups received intracerebroventricular NPY (1 g NPY/2.5-l dose) daily between two and seven days of age (n = 200 pups). The second group received 2.5 l of vehicle (n = 200 pups).

The 2-7 days of age were chosen for intervention, because this is the critical period of hypothalamic development that has previously been observed to have permanent effects lasting into adulthood. All intracerebroventricular injections were performed using the conventional stereotaxic coordinates for the adult rat lateral ventricle. Individua
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Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
29-Jul-2003


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