HOME >> BIOLOGY >> NEWS
Can female adult obesity be stopped at birth?

l pups in each litter were weighed daily between 8 and 10 AM. On weaning of the pups at 21 days, body weight was assessed once every 10 days until 120 days of age. Food intake was measured over a 24-h period by weighing the rat chow at the beginning and end of the 24-h period, accounting for spillage and evaporation.

At 120 days of age, the female animals in the neonatal NPY- or vehicle-treated groups were further divided into two groups each, one that received 10 g of NPY/2.5-l dose and the other that received an equal volume of vehicle, thereby leading to a total of four adult experimental groups. These four groups were NPY-NPY, NPY-vehicle, vehicle-NPY, and vehicle-vehicle. All animals were anesthetized with a combination of ketamine (40 mg/kg) and xylazine (8 mg/kg). The 120-day-old animals subjected to stereotaxic surgery were weighed before surgery and every day between 8 and 10 AM, spanning a total of three days. In addition, food intake was measured over a 24-hour period daily spanning a three-day period beginning on 121 days and lasting through 123 days.

Results

The following results were observed:

After injecting intracerebroventricular NPY on a daily basis between days 2-7 of life, the researchers observed an immediate increase in body weight gain within 24 hours of initiating treatment compared with the vehicle treatment group (NPY = 1.58 0.07 vs. vehicle = 1.2 0.03 g;). This 32 percent increase in body weight resolved in 48 hours and was no longer evident throughout the suckling phase despite ongoing NPY administration until day 7. However, beginning on day 60, a significant decline in body weight gain and food intake was observed in females that persisted through 120 days. In contrast, no statistically significant change in either the food intake or body weight gain pattern was observed in males.

The newborn animals that received NPY demonstrated hyperinsulinemia at three days of age, with no change in glucos
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
29-Jul-2003


Page: 1 2 3 4 5

Related biology news :

1. When male fish hum, females swim in, thanks to hormones, adaptable hearing
2. Feeding cottonseed meal to female fallow deer safe at low rates
3. For a male sand goby, playing Mr. Mom is key to females heart
4. MGH study finds female mammals produce egg cells into adulthood
5. Link between alcohol consumption and muscle damage in females
6. OHSU researchers reveal relationship between weight gain and female hormones
7. Male flesh flies high-speed pursuit of females
8. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
9. Chlamydia infection prevalent among female army recruits
10. Newly mapped enzyme could yield new treatments for female sexual dysfunction
11. Four gene micronet found to regulate social behavior in female mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2020)... ... ... Liver cancer, called hepatocellular carcinoma (HCC), occurs each year in more than ... the 5th most common cancer and the 2nd leading cause of cancer deaths. Mongolia ... HCC, while China has half of all patients suffering from liver cancer. The incidence ...
(Date:1/28/2020)... Mass. (PRWEB) , ... January 28, 2020 , ... ... for life sciences companies and government agencies, announced that the firm has established ... the country. Tunnell’s Cambridge office will be in the Cambridge Innovation Center (CIC), ...
(Date:1/24/2020)... ... January 24, 2020 , ... The ... Colorado’s capital resources to support early-stage bioscience companies in the state. ... struggled to find the funding they need to innovate and grow. This ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... The impact of new medicines, ... laboratory and clinical services during the first two decades of the 21st century ... Slone Partners celebrates its 20th anniversary this year, its evolution as ...
(Date:1/22/2020)... ... January 21, 2020 , ... Microbial ... as Southern Midwest Region Industrial and Institutional (I&I) Account Manager. Darrell will focus ... , Darrell brings over 30 years of sales experience working across multiple ...
(Date:1/10/2020)... Pa. (PRWEB) , ... January 09, 2020 , ... ... software and expert services, today announced the acquisition of Cunesoft, a move that ... meet the business objectives of life sciences companies. , Based in Munich, Germany, ...
(Date:1/7/2020)... ... 07, 2020 , ... Absolute Antibody Ltd. , an ... its VivopureX™ recombinant mouse antibodies for in vivo research in mouse models. The ... which Absolute Antibody has engineered into mouse-anti-mouse recombinant versions to improve research results. ...
Breaking Biology Technology:
Cached News: