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Can female adult obesity be stopped at birth?

l pups in each litter were weighed daily between 8 and 10 AM. On weaning of the pups at 21 days, body weight was assessed once every 10 days until 120 days of age. Food intake was measured over a 24-h period by weighing the rat chow at the beginning and end of the 24-h period, accounting for spillage and evaporation.

At 120 days of age, the female animals in the neonatal NPY- or vehicle-treated groups were further divided into two groups each, one that received 10 g of NPY/2.5-l dose and the other that received an equal volume of vehicle, thereby leading to a total of four adult experimental groups. These four groups were NPY-NPY, NPY-vehicle, vehicle-NPY, and vehicle-vehicle. All animals were anesthetized with a combination of ketamine (40 mg/kg) and xylazine (8 mg/kg). The 120-day-old animals subjected to stereotaxic surgery were weighed before surgery and every day between 8 and 10 AM, spanning a total of three days. In addition, food intake was measured over a 24-hour period daily spanning a three-day period beginning on 121 days and lasting through 123 days.

Results

The following results were observed:

After injecting intracerebroventricular NPY on a daily basis between days 2-7 of life, the researchers observed an immediate increase in body weight gain within 24 hours of initiating treatment compared with the vehicle treatment group (NPY = 1.58 0.07 vs. vehicle = 1.2 0.03 g;). This 32 percent increase in body weight resolved in 48 hours and was no longer evident throughout the suckling phase despite ongoing NPY administration until day 7. However, beginning on day 60, a significant decline in body weight gain and food intake was observed in females that persisted through 120 days. In contrast, no statistically significant change in either the food intake or body weight gain pattern was observed in males.

The newborn animals that received NPY demonstrated hyperinsulinemia at three days of age, with no change in glucos
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Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
29-Jul-2003


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