HOME >> BIOLOGY >> NEWS
Cancer Cells Self-Destruct When "Sweet Tooth" Is Thwarted

"We knew very quickly that the cells we had altered to resemble cancers were dying off in large numbers."

Johns Hopkins researchers have found evidence that some cancer cells are such incredible sugar junkies that they'll self-destruct when deprived of glucose, their biological sweet of choice.

"The change when we took away glucose was dramatic," says Chi Van Dang, M.D., Ph.D., director of hematology. "By the next day, we knew very quickly that the cells we had altered to resemble cancers were dying off in large numbers."

Scientists have long suspected that the cancer cell's heavy reliance on glucose, its main source of strength and vitality, also could be one of its great weaknesses, and Dang's new results are among the most direct proofs yet of the idea.

Results of the study, published in the February 17 issue of the Proceedings of the National Academy of Sciences, suggest that drugs which cut off the glucose supply may be a potent way of fighting cancer with few ill effects on healthy tissues.

With funding from the National Institutes of Health, Hyunsuk Shim, Ph.D., a postdoctoral fellow, Dang and others gave embryonic mouse cells an unusually active form of a gene known as c-Myc. Many cancer cells overuse this gene, mass-producing its protein to start chain reactions that help them switch from using oxygen for energy production to using glucose.

"When we bathed cells with high c-Myc levels in a cell medium with no glucose, they destroyed themselves by triggering a cell suicide process called apoptosis," says Dang. "Cells we hadn't altered stopped moving through the cellular life cycle, staying in the first two stages of cell development, and appeared fine in all other regards."

Dang produced similar results by exposing both types of cells to 2-deoxyglucose, a compound that resembles sugar but disrupts glycolysis, t
'"/>

Contact: Michael Purdy
mpurdy@welchlink.welch.jhu.edu
(410)955-8725
Johns Hopkins Medical Institutions
17-Feb-1998


Page: 1 2

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments ... consulting, Nanoscience Analytical offers a broad range of contract analysis services for ...
Breaking Biology Technology:
Cached News: