HOME >> BIOLOGY >> NEWS
Cancer Cells Self-Destruct When "Sweet Tooth" Is Thwarted

"We knew very quickly that the cells we had altered to resemble cancers were dying off in large numbers."

Johns Hopkins researchers have found evidence that some cancer cells are such incredible sugar junkies that they'll self-destruct when deprived of glucose, their biological sweet of choice.

"The change when we took away glucose was dramatic," says Chi Van Dang, M.D., Ph.D., director of hematology. "By the next day, we knew very quickly that the cells we had altered to resemble cancers were dying off in large numbers."

Scientists have long suspected that the cancer cell's heavy reliance on glucose, its main source of strength and vitality, also could be one of its great weaknesses, and Dang's new results are among the most direct proofs yet of the idea.

Results of the study, published in the February 17 issue of the Proceedings of the National Academy of Sciences, suggest that drugs which cut off the glucose supply may be a potent way of fighting cancer with few ill effects on healthy tissues.

With funding from the National Institutes of Health, Hyunsuk Shim, Ph.D., a postdoctoral fellow, Dang and others gave embryonic mouse cells an unusually active form of a gene known as c-Myc. Many cancer cells overuse this gene, mass-producing its protein to start chain reactions that help them switch from using oxygen for energy production to using glucose.

"When we bathed cells with high c-Myc levels in a cell medium with no glucose, they destroyed themselves by triggering a cell suicide process called apoptosis," says Dang. "Cells we hadn't altered stopped moving through the cellular life cycle, staying in the first two stages of cell development, and appeared fine in all other regards."

Dang produced similar results by exposing both types of cells to 2-deoxyglucose, a compound that resembles sugar but disrupts glycolysis, t
'"/>

Contact: Michael Purdy
mpurdy@welchlink.welch.jhu.edu
(410)955-8725
Johns Hopkins Medical Institutions
17-Feb-1998


Page: 1 2

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: