Cancer Test May Offer High-Risk Groups Quick, Affordable Screening For Tumors

New Technique Is Among The First Envisioned For A Wide Variety Of Tumor Types

Johns Hopkins researchers have developed a new test that may allow doctors to regularly and quickly check for early cancers in patients at risk for developing cancer due to genetic or environmental factors.

The test temporarily slows DNA production in cancer cells, causing some elements of DNA to accumulate in the blood. When these materials are excreted in large amounts in urine, they indicate the presence of cancer.

Hopkins researchers found 8 of 11 cancer patients tested positive for cancer using the new technique. The patients, who were diagnosed with cancer before taking the new test, had a variety of tumors. The results of the study, supported in part by an American Society of Clinical Oncology Young Investigator Award and by the National Institute of Child Health and Human Development, appear in the May issue of In Vivo.

Scientists say initial results are promising but the test must be validated by additional research.

"We must study larger groups of patients, and if these preliminary results are confirmed, doctors possibly could use the test for the early detection of tumors in patients at risk for cancer," says Saul Brusilow, M.D., professor of pediatrics. "It might also be useful as a post-surgical test for residual cancer cells."

For the test, patients gave a baseline urine sample and took one allopurinol pill. This drug, ordinarily used to treat gout, also temporarily interferes with the production of elements of DNA called pyrimidines. Patients' urine was then collected in four periods over the next 24 hours and tested for increased levels of orotidine and orotate, two compounds used to build pyrimidines.

Increases in the levels of these compounds were surprisingly large.

"These dramatic changes suggest that

Contact: Michael Purdy
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:

(Date:1/14/2019)... ... January 14, 2019 , ... Join ... (4pm GMT) to hear about key topics in data quality, including:, ... ,     Patient engagement ,     Smartphone and wearable based performance measures , ...
(Date:1/8/2019)... ... January 07, 2019 , ... Join industry experts Julie Peacock, ... live webinar on Thursday, January 17, 2019 at 1pm EST. , ... risk during the clinical trial process. Featured speakers will also present a case study ...
(Date:1/7/2019)... ... January 07, 2019 , ... ... supplier of Graph Database technology for Knowledge Graphs solutions, announced that it was ... ‘Trend-Setting’ Product . DBTA’s data and information management recognition list includes newer ...
Breaking Biology News(10 mins):
(Date:12/19/2018)... ... December 19, 2018 , ... ... first rate Stem Cell Training Course in Las Vegas. Training includes facial rejuvenation, ... procedures explode in popularity nationwide for aesthetics, having the training from expert, Board ...
(Date:12/18/2018)... ... December 18, 2018 , ... USDM Life ... the life sciences industry, unveiled a completely redesigned website at http://www.usdm.com . ... browsing experience for their valued clients and business partners. , The website ...
(Date:12/13/2018)... ... December 11, 2018 , ... Researchers at ... use to quickly detect Clostridium difficile (C. diff), a dangerous and sometimes fatal ... device that can be used onsite in doctor’s offices and nursing homes, providing ...
(Date:12/13/2018)... ... December 13, 2018 , ... Microbial Discovery Group ... This has been part of their strategic plan and an important milestone in ... custom fermentation opportunities for MDG within the $44 Billion human probiotic market. This ...
Breaking Biology Technology:
Cached News: