HOME >> BIOLOGY >> NEWS
Cancer biologists and a cardiologist take a new look at aggressive tumors

An unusual collaboration between a University of Iowa cardiologist and cancer biologists at the Holden Comprehensive Cancer Center at the UI, the Scripps Research Institute in California and Kanagawa Cancer Center Hospital and Research Center in Japan utilized a multidisciplinary approach to learn more about how aggressive cancer cells function and how they differ from poorly aggressive cancer cells. The study, which appears in the Sept. 1 issue of Cancer Research, may also suggest potential new therapeutic targets for cancer treatment.

Previous studies have found that aggressive tumor cells express genes that are more normally associated with other cell types, including endothelial cells that line blood vessels. Also, aggressive cancer cells are able to form vascular-like, fluid-conducting networks, an ability known as vasculogenic mimicry that resembles the behavior of embryonic cells that form primitive vascular networks.

Patients' tumors that have fluid-conducting networks are much more aggressive than tumors that do not have those networks.

The present study focuses on just a few of the genes that are expressed by aggressive cancer cells but not by poorly aggressive tumor cells. These genes normally are involved in regulating anticoagulant, or blood-clotting, activity in endothelial cells. The study suggests that the expression of these genes by aggressive tumor cells provides the cells with anticoagulant capabilities that are similar to those in blood vessel cells.

"Essentially our observations indicated that the aggressive melanoma tumor cells behaved in a similar manner as do endothelial cells that form blood vessels," said Mary Hendrix, Ph.D., the Kate Daum Research Professor of Anatomy and Cell Biology and head of the department.

The finding that tumor cells have anticoagulant properties similar to endothelial cells prompted the researchers to analyze whether there was blood flow within these tumors in extravascula
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
4-Sep-2003


Page: 1 2

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... LIVERMORE, Calif. , March 21, 2017 ... recognition analytics company serving law enforcement agencies, announced today ... Sheridan as director of public safety business development. ... of diversified law enforcement experience, including a focus on ... Vigilant. In his most recent position, Mr. Sheridan served ...
(Date:3/9/2017)... , March 9, 2017 4Dx has publicly ... Lung Imaging Workshop at the University of Pennsylvania. Founder ... to deliver the latest data to world leaders in ... brings together leaders at the forefront of the industry ... imaging. "The quality of the imaging ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... 2017 In today,s pre-market research, ... Intrexon Corp. (NYSE: XON), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX), ... According an article on Barron,s, Credit Suisse upgraded its rating ... March 21 st , 2017. These stocks research reports can ... ...
(Date:3/29/2017)... Pa. , March 29, 2017 Patients ... which is why CSL Behring awards Local Empowerment for ... rare disease patient groups. These groups tackle complex legislative ... heard on Capitol Hill and in statehouses across the ... the community-based grant was awarded to New England Hemophilia ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - Last year,s petition ... are not the only efforts active to generate awareness on the ... based pharmaceutical drugs in the healthcare market place. ... Earlier this month Health ... and distributor of pharmaceutical and nutritional products, announced its endeavors on ...
(Date:3/29/2017)... Alto, CA, USA (PRWEB) , ... March 29, 2017 , ... ... in various regulatory subjects has announced its 3rd Annual Medical Device Summit 2017 venue ... at the Omni Parker House Hotel, in Boston, MA. , The Omni Parker House ...
Breaking Biology Technology:
Cached News: