HOME >> BIOLOGY >> NEWS
Cancer gene is normally a 'carpenter' in the cell

-chronic myelogeneous leukemia and acute lymphoblastic leukemia. Basically, these leukemias occur when chromosomes in dividing white blood cells become snipped apart and restitched incorrectly, with the c-Abl gene becoming linked to a gene called BCR that switches c-Abl on, causing the blood cells to proliferate out of control.

However, the normal role of c-Abl remained unknown, despite studies in other laboratories that linked the homolog of c-Abl in fruit flies with the growth of nerve cells and the metabolic pathways governing formation and rearrangement of the cytoskeleton.

In their experiments, the Duke Medical Center researchers basically explored the effects of genetically manipulating mouse cells called fibroblasts to alter the levels of the growth factors and the protein enzymes produced by c-Abl and Src. Both these enzymes are chemical switches called tyrosine kinases, that trigger other proteins by adding a phosphate to the amino acid tyrosine that is part of the protein.

By altering levels of the growth factors and Src, in the mouse cells and observing the effects on c-Abl, the scientists could determine whether they were part of the normal pathway by which c-Abl functioned.

The pharmacologists' measurements revealed that the growth factors and the Src protein did trigger the activity of c-Abl protein. What's more, their studies revealed that the Src added phosphate to the c-Abl protein, the normal action of a kinase triggering another enzyme.

The scientists also found hints of another pathway by which the growth factors activate c-Abl without triggering Src.

Finally, they found that c-Abl was necessary for cells to undergo cytoskeletal reorganization in response to PDGF. For example, when fibroblast cells that lacked c-Abl were "starved" of serum and then the PDGF growth factor was added, they were unable to remodel their cytoskeleton, as revealed by microscopic studies. However, cells with c-
'"/>

Contact: Dennis Meredith
Dennis.meredith@duke.edu
919-681-8054
Duke University
28-Sep-1999


Page: 1 2 3

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
(Date:12/12/2016)... 2016  Researchers at Trinity College, Dublin, are ... combining the material with Silly Putty. The mixture (known ... able to sense pulse, blood pressure, respiration, and ... The research team,s findings were published ... http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/7/2016)... India , December 7, 2016 According to a ... Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End User, ... is estimated to grow from USD 6.72 Billion in 2016 to USD 36.07 ... Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 19, 2017 , ... Genedata, ... (R&D), today announced the launch of Data Science Services , offering ... evolving field of precision medicine. , Data Science Services allows pharmaceutical ...
(Date:1/19/2017)... and GAITHERSBURG, Md. ... MKT: PIP) and Altimmune, Inc., a privately-held immunotherapeutics ... of a definitive agreement for the merger of ... current investors include Novartis Venture Fund, HealthCap, Truffle ... be a fully-integrated and diversified immunotherapeutics company with ...
(Date:1/19/2017)... AquaBounty Technologies, Inc. (AIM: ABTU; NASDAQ: AQB), ... and a majority-owned subsidiary of Intrexon Corporation (NYSE: ... listing of its common shares on the NASDAQ Stock ... "AquaBounty,s listing on NASDAQ represents an important milestone ... the U.S. markets as we advance plans for commercial ...
(Date:1/19/2017)... Ca (PRWEB) , ... January 18, 2017 , ... ... events for tech innovators, engineers, and scientists from around the world, was today ... News. The awards program is based entirely on merit and decided upon by ...
Breaking Biology Technology:
Cached News: