HOME >> BIOLOGY >> NEWS
Cancer gene is normally a 'carpenter' in the cell

-chronic myelogeneous leukemia and acute lymphoblastic leukemia. Basically, these leukemias occur when chromosomes in dividing white blood cells become snipped apart and restitched incorrectly, with the c-Abl gene becoming linked to a gene called BCR that switches c-Abl on, causing the blood cells to proliferate out of control.

However, the normal role of c-Abl remained unknown, despite studies in other laboratories that linked the homolog of c-Abl in fruit flies with the growth of nerve cells and the metabolic pathways governing formation and rearrangement of the cytoskeleton.

In their experiments, the Duke Medical Center researchers basically explored the effects of genetically manipulating mouse cells called fibroblasts to alter the levels of the growth factors and the protein enzymes produced by c-Abl and Src. Both these enzymes are chemical switches called tyrosine kinases, that trigger other proteins by adding a phosphate to the amino acid tyrosine that is part of the protein.

By altering levels of the growth factors and Src, in the mouse cells and observing the effects on c-Abl, the scientists could determine whether they were part of the normal pathway by which c-Abl functioned.

The pharmacologists' measurements revealed that the growth factors and the Src protein did trigger the activity of c-Abl protein. What's more, their studies revealed that the Src added phosphate to the c-Abl protein, the normal action of a kinase triggering another enzyme.

The scientists also found hints of another pathway by which the growth factors activate c-Abl without triggering Src.

Finally, they found that c-Abl was necessary for cells to undergo cytoskeletal reorganization in response to PDGF. For example, when fibroblast cells that lacked c-Abl were "starved" of serum and then the PDGF growth factor was added, they were unable to remodel their cytoskeleton, as revealed by microscopic studies. However, cells with c-
'"/>

Contact: Dennis Meredith
Dennis.meredith@duke.edu
919-681-8054
Duke University
28-Sep-1999


Page: 1 2 3

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer gene normally carpenter the cell

(Date:10/30/2014)... is available in German . ... prompt our fellow humans to behave socially? This is ... in game theory. Previous studies assumed that it is ... scientists from the Max Planck Institute for Evolutionary Biology ... an influence on the cooperative behaviour of others. However, ...
(Date:10/30/2014)... | Heidelberg, 30 October 2014 Biological membranes are ... understanding of adsorption of solution ions onto lipid ... Now, a new study provides a quantitative description ... solution ions. Joanna Kotyńska and Zbigniew Figaszewski from ... of a study describing these findings, just published ...
(Date:10/29/2014)... of its kind to date, researchers have used DNA ... risk for autism. Joseph Buxbaum, Ph.D., Icahn School of ... Ph.D., Broad Institute of Harvard and MIT, and their ... children, parents and unrelated people. They identified changes in ... risk for autism spectrum disorder (ASD) – a jump ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Ion adsorption matter in biology 2
(Date:10/30/2014)... Diego, CA (PRWEB) October 30, 2014 ... announced today that they have manually curated public data ... and non profit customers. the data is now ... manually curates and unifies public and internal data sources ... value and knowledge out of the data that becomes ...
(Date:10/30/2014)... UAE (PRWEB) October 30, 2014 Grace Century ... Dr. James A. Manganello, Chairman of the Board, to the ... Bahamas. The appointment was made by the Ministry of ... September 24th, 2014. , More than a year ... Research Bill , Prime Minister Perry Christie said the government ...
(Date:10/30/2014)... 2014) – The severe flooding that devastated a wide ... destructive if the bridges, roads and other infrastructure had ... from the University of Colorado Denver. , "People need ... Jimmy Kim, PhD, associate professor of structural engineering at ... and lead author the study. "There is an assumption ...
(Date:10/27/2014)... 27, 2014 Kalorama Information says that PCR ... in the United States and ... market researcher said the FDA,s Emergency Use Authorization (EUA) to ... for the detection of the Ebola virus was an ... routinely assess the IVD industry and its biennial survey ...
Breaking Biology Technology:Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3
Cached News: