HOME >> BIOLOGY >> NEWS
Cancer gene is normally a 'carpenter' in the cell

-chronic myelogeneous leukemia and acute lymphoblastic leukemia. Basically, these leukemias occur when chromosomes in dividing white blood cells become snipped apart and restitched incorrectly, with the c-Abl gene becoming linked to a gene called BCR that switches c-Abl on, causing the blood cells to proliferate out of control.

However, the normal role of c-Abl remained unknown, despite studies in other laboratories that linked the homolog of c-Abl in fruit flies with the growth of nerve cells and the metabolic pathways governing formation and rearrangement of the cytoskeleton.

In their experiments, the Duke Medical Center researchers basically explored the effects of genetically manipulating mouse cells called fibroblasts to alter the levels of the growth factors and the protein enzymes produced by c-Abl and Src. Both these enzymes are chemical switches called tyrosine kinases, that trigger other proteins by adding a phosphate to the amino acid tyrosine that is part of the protein.

By altering levels of the growth factors and Src, in the mouse cells and observing the effects on c-Abl, the scientists could determine whether they were part of the normal pathway by which c-Abl functioned.

The pharmacologists' measurements revealed that the growth factors and the Src protein did trigger the activity of c-Abl protein. What's more, their studies revealed that the Src added phosphate to the c-Abl protein, the normal action of a kinase triggering another enzyme.

The scientists also found hints of another pathway by which the growth factors activate c-Abl without triggering Src.

Finally, they found that c-Abl was necessary for cells to undergo cytoskeletal reorganization in response to PDGF. For example, when fibroblast cells that lacked c-Abl were "starved" of serum and then the PDGF growth factor was added, they were unable to remodel their cytoskeleton, as revealed by microscopic studies. However, cells with c-
'"/>

Contact: Dennis Meredith
Dennis.meredith@duke.edu
919-681-8054
Duke University
28-Sep-1999


Page: 1 2 3

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Energetiq ... has announced a facility expansion to accommodate its rapid growth. , The renovations ... workspace and renovation of the existing areas. The expansion includes, a state-of-the-art engineering ...
(Date:5/22/2017)... ... ... Stratevi, a boutique firm that partners with healthcare companies to creatively develop ... in downtown Boston at 745 Atlantic Ave. , “We are seeing that even ... the value they provide, not just to patients, but also payers. Having a presence ...
(Date:5/19/2017)... Shirley, New York (PRWEB) , ... May 19, 2017 , ... ... therapy techniques in treating gait disorders, Biodex Medical Systems, Inc. announces the release of ... time music therapy has been joined with a biomedical system to aid in rehabilitating ...
(Date:5/18/2017)... ... 2017 , ... NDA Partners Chairman Carl Peck, MD , announced today ... and President of Pharmaceutical Development Business Unit of Cardinal Health, has joined the firm ... he was former Chief Operating Officer at Anaborex, Senior VP and General Manager of ...
Breaking Biology Technology:
Cached News: